The present disclosure relates to a mutant filamentous fungal host cell which is deficient in the zinc binuclear cluster transcriptional regulator oreR or in a functional homologue thereof if compared with a parent filamentous fungal host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant filamentous fungal host cell according to the disclosure is used in a method to produce a compound of interest by microbial fermentation, for example an enzyme, substantially no oxalic acid is produced extracellularly by the cell during the fermentation as a by-product, which allows a more economical and efficient recovery of the compound of interest from the fermentation broth.

The present disclosure relates to a mutant filamentous fungal host cell which is deficient in the zinc binuclear cluster transcriptional regulator oreR or in a functional homologue thereof if compared with a parent filamentous fungal host cell which has not been modified and measured under the same conditions. It has been surprisingly found that when the mutant filamentous fungal host cell according to the disclosure is used in a method to produce a compound of interest by microbial fermentation, for example an enzyme, substantially no oxalic acid is produced extracellularly by the cell during the fermentation as a by-product, which allows a more economical and efficient recovery of the compound of interest from the fermentation broth.

The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a heterocyclic compound. The present invention also relates to methods of using the compositions.

The present invention relates to compositions comprising: a polypeptide having cellulolytic enhancing activity and a heterocyclic compound. The present invention also relates to methods of using the compositions.

The present disclosure relates generally to herbicidal compositions and methods of use thereof, and more specifically to herbicidal compositions containing aspterric acid or a derivative thereof for use in inhibiting vegetative growth in plants.

The present invention relates to RImA-inactivated filamentous fungal cells secreting a polypeptide of interest and methods of producing a secreted polypeptide of interest in said cells as well as methods of producing said cells.

A gene for biosynthesis of core structure of ophiobolin, the gene being the AuOS gene of Aspergillus sp. 094102, deposited with the accession number CCTCC No: M208153, the gene sequence thereof being shown as SEQ ID NO. 1. Also provided is a method of preparation of ophiobolin using the gene.

A gene for biosynthesis of core structure of ophiobolin, the gene being the AuOS gene of Aspergillus sp. 094102, deposited with the accession number CCTCC No: M208153, the gene sequence thereof being shown as SEQ ID NO. 1. Also provided is a method of preparation of ophiobolin using the gene.

The present disclosure provides a microbial genomic engineering method and system for transforming, screening, and selecting filamentous fungal cells that have altered morphology and/or growth under specific growth conditions. The method and system utilize high-throughput (HTP) methods to produce filamentous fungal production strains with a desired morphological phenotype.

The present invention relates to a method of increasing resistance against fungal pathogens of the family Phacosporaceae plants and/or plant cells. This is achieved for instance by increasing the expression of a hydrophobin protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells. In the transgenic plants hydrophobin can be expressed as a fusion protein to facilitate and/or enhance expression. Furthermore, the hydrophobin protein can be expressed including a secretion signal sequence which mediates secretion of the protein into the apoplast and/or into the cuticule.