The present invention provides novel antibodies and antigen binding fragments thereof that bind to human CD30. Also presented are single chain variable antibodies, chimeric antigen receptors and uses thereof. Methods of treating cancer are also disclosed.

The purpose of the present invention is to provide a method for detecting, in a selective and simple manner, an oxidized form of HD5 which is human α-defensin, that is, HD5 having intramolecular disulfide bonds that function beneficially in the human body.

[Solution] The present invention relates to: two kinds of novel monoclonal antibodies that contain amino acid sequences of SEQ ID NO: 1-6 or 7-12 as a CDR and that specifically bind to human α-defensin HD5 having intramolecular disulfide bonds; an immunological detection method using the antibodies; and a kit containing the antibodies.

The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

Provided are recombinant antibodies comprising one or more peptides fused to the C-terminus of the light chain constant region. Recombinant immunocytokines comprising a cytokine fused to the C-terminus of the light chain constant region are described and shown to be surprisingly active.

The present invention relates to a Fab fragment based switchable antibody system for generating site-specific antibody conjugates. Methods are described for the attachment of molecules to specific sites the Fab fragment and for the attachment of the Fab fragment to a target molecule (e.g., an antibody) directed against any desired target antigen (tumor, bacterial, fungal, viral, parasitic etc.) The attachment is via binding of the Fab fragment to an epitope linked to the target molecule.

The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Antibody drug conjugates (ADCs) comprising an antibody conjugated to an anti-inflammatory therapeutic agent via a phosphate-based linker with tunable extracellular and intracellular stability are described.

The present invention relates to methods of using compounds that inhibit the enzymatic activity of soluble human CD39 to treat cancer, including but not limited to the treatment of cancers characterized by CD73 expressing cells.

The present invention relates to antigen binding molecules, including antibodies, fragments, and variants thereof, that bind to the TNF-related cytokine LIGHT (TNFSF14). The present invention also relates to methods of use of such antigen binding molecules in treating and/or preventing inflammatory disorders and immune disorders.

The present invention relates to novel amyloid-beta (abeta) binding molecules, in particular to abeta antibodies or antigen-binding fragments thereof and/or uses thereof. The provided molecules can also be used for determining a predisposition to amyloid-beta associated diseases, disorders or conditions, monitoring residual disorder of a disease or condition, or predicting the responsiveness of a patient who is suffering from such disease or condition to the treatment with a certain medicament. Thus, the invention relates to novel molecules that can be employed for the diagnosis of diseases, disorders or conditions associated with amyloid-beta. A sandwich immunoassay may be based on capture and detection amyloid-beta binding antibodies or antigen-binding fragments thereof in which one or other of the capture or detection antibody or antigen-binding fragment thereof displays no cross-reactivity to soluble amyloid precursor protein (APP). The other amyloid-beta binding antibody or antigen-binding fragment my display cross-reactivity to soluble amyloid precursor protein (APP) without compromising the specificity of the assay against soluble APP.