The present invention relates to a silicone acrylamide copolymer of high acrylamide monomer content which has transparency and low modulus, employing the following configuration. The copolymer is suitably used for various kinds of medical devices, particularly ophthalmic lenses such as a contact lens, an intraocular lens, an artificial cornea, and is especially suitable for a contact lens. A copolymer comprising (A) a multi-functional (meth)acrylamide monomer having at least one siloxane bond and at least two (meth)acrylamide groups within a molecule and (B) a mono-functional linear silicone (meth)acrylamide monomer.

The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances.

Biocompatible copolymers and thermo-responsive hydrogels formed from the copolymers are disclosed. The biocompatible copolymers include monomers comprising polysaccharides or derivatives thereof, therapeutic agents or derivatives thereof and thermo-responsive monomers and are cross-linked with an acrylamide-containing crosslinker. The hydrogels are used as implant materials to treat or prevent joint damage or osteoarthritis in a subject.

Biocompatible copolymers and thermo-responsive hydrogels formed from the copolymers are disclosed. The biocompatible copolymers include monomers comprising polysaccharides or derivatives thereof, therapeutic agents or derivatives thereof and thermo-responsive monomers and are cross-linked with an acrylamide-containing crosslinker. The hydrogels are used as implant materials to treat or prevent joint damage or osteoarthritis in a subject.

A polymerizable composition includes an amide compound represented by Formula (1) and a polymerization initiator.

A polymerizable composition includes an amide compound represented by Formula (1) and a polymerization initiator.

A polymerizable composition includes an amide compound represented by Formula (1) and a polymerization initiator.

A process for preparation of a polymer product comprising the steps of i) feeding an aqueous mixture comprising a monoethylenically unsaturated monomer or a mixture of monoethylenically unsaturated monomers into a first reactor device (2) through at least one inlet; ii) partially polymerizing the monomer or monomers and transferring the polymerizing monomer or mixture of monomers from the inlet to an outlet (3) of the first reactor device (2) to provide a partially polymerized product; iii) flowing the partially polymerized product out of the outlet (3), in which no more than 60% of the monomer or mixture of monomers has been polymerized in the partially polymerized product as it exits the outlet (3) of first reactor device (2), and transferring it to a further reactor device (5), in which the further reactor device (5) has an inlet and an outlet (6);
iv) continuing the polymerization in the further reactor device (5) and removing the polymer product from the outlet (6) of the further reactor device (5),
characterized in that the first reactor device (2) comprises a positive displacement pump.

A process for preparation of a polymer product comprising the steps of i) feeding an aqueous mixture comprising a monoethylenically unsaturated monomer or a mixture of monoethylenically unsaturated monomers into a first reactor device (2) through at least one inlet; ii) partially polymerizing the monomer or monomers and transferring the polymerizing monomer or mixture of monomers from the inlet to an outlet (3) of the first reactor device (2) to provide a partially polymerized product; iii) flowing the partially polymerized product out of the outlet (3), in which no more than 60% of the monomer or mixture of monomers has been polymerized in the partially polymerized product as it exits the outlet (3) of first reactor device (2), and transferring it to a further reactor device (5), in which the further reactor device (5) has an inlet and an outlet (6);
iv) continuing the polymerization in the further reactor device (5) and removing the polymer product from the outlet (6) of the further reactor device (5),
characterized in that the first reactor device (2) comprises a positive displacement pump.

Disclosed is a hydrophilic dressing (200) having appropriate mechanical strength, comprising a composite material (100, 220) and a film (210). The composite material (100, 220) comprises a hydrophilic substrate material (110) and a compound (120) that promotes wound healing, wherein the hydrophilic substrate material (110) is a reaction product of a hydrophilic polymer, wherein the hydrophilic polymer comprises a hydrophilic monomer, a cross-linking agent and an inorganic silicon-oxygen compound, wherein the compound (120) that promotes wound healing is distributed in the hydrophilic substrate material (110).