The present invention relates to macromolecular transition metal complexes, characterized by having the general formula (I), to the process for their preparation, and to bidentate and monodentate macroligands. The invention also refers to pharmaceutical compositions and medicaments containing said macromolecular transition metal complexes, and to the use of said pharmaceutical compositions, medicaments and macromolecular transition metal complexes for cancer therapy and/or cancer prevention, as antitumor agent in solid tumors, liquid tumors and/or metastases and/or as radiosensitizer agents.

Described herein is a feasible, significantly simplified production method that avoids challenging lactonization steps and converts a low molecular weight aliphatic polyester, consisting of hydroxy acids and a comonomer, whose molecular weight has been increased by step-growth polymerization reactions. The molecular weight of the aliphatic polyester, based on comparison of initial and final weight average molecular weights (M.sub.w,1/M.sub.w,2), increased significantly at a rate which permits the use of reactive extrusion to produce high molecular weight aliphatic polyesters in a simple, economically feasible manner.

The process includes pretreating the biomass with a first basic solution such as sodium hydroxide and mechanically altering the fibers to provide a fluidized biomass. The fluidized biomass is then subjected to high frequency pulses and shear forces without denaturing the individual components of the biomass. The biomass is then subjected to compressive force to separate a first liquid fraction from a first fractionated biomass. The first fractionated biomass may again then be subjected to the same high frequency pulses and shear forces as previously, particularly if there are hemicellulose and/or sugars still present in the first fractionated biomass. Compressive forces are used to separate a second liquid fraction from a second fractionated biomass. The second fractioned biomass is then subjected to compressive forces to provide lignin in water soluble form.

Compositions of high molecular weight poly(hydroxy acid) polymer having good thermal stability and a weight average molecular weight of >100,000 by GPC. The compositions include one or more chain-terminator compounds/impurities which may be incorporated into the polymer and rendered harmless by the presence of appropriate amounts of bi-functional and multi-functional polymerization initiators. A process including first mixing glycolic acid and/or lactic acid (with chain-terminators), and a diol or di-acid initiator, and at least one multifunctional initiator to form a liquid monomer mixture in an agitated polycondensation reactor. Next, polycondensing to form a liquid reaction mixture comprising a pre-polymer having a weight average molecular weight of >10,000 by GPC, and greater than 80% by mole hydroxyl or carboxyl end-group termination, then crystallizing to form a first solid reaction mixture. Then, solid state polycondensing the solid reaction mixture to form a solid reaction mixture having a moisture level less than 50 ppm by weight. Then, mixing the solid reaction mixture with an appropriate reactive coupling agent in a melting and mixing extruder to couple and form the reaction mixture and form the final poly(hydroxy acid) polymer.

A polyester blend is made in a reaction of a linear polylactide resin and a thermoplastic epoxy group-containing polymer. The polyester blend is blended with a polyester having a glass transition temperature below 0C to form a polyester blend that is particular useful for making paperboard coatings in a melt extrusion process.

Compounds and compositions are provided which are useful in additive printing, particularly additive printing techniques such as stereolithography (SLA) wherein a macromer is photopolymerized to form a manufactured article. Representative compounds comprise a polyaxial central core (CC) and 2-4 arms of the formula (A)-(B) or (B)-(A) extending from the central core, where at least one of the arms comprise a light-reactive functional group (Q) and (A) is the free-radical polymerization product from monomers selected from trimethylene carbonate (T) and ε-caprolactone (C), while (B) is the free-radical polymerization product from monomers selected from glycolide, lactide and ρ-dioxanone.

The present invention is a method to produce a biodegradable thermally induced shape memory polymer (SMP) based on poly(ε-caprolactone) (PCL) and ethyl cellulose (EC). In this synthesis method, after grafting the PCL on the linear EC, the PCL chains are end-functionalized with furan and maleimide moieties. The cross-linked network is prepared via Diels-Alder (DA) reaction between furanyl and N- maleimidyl PCL chains. The synthesized SMP demonstrates excellent shape memory properties at near body temperature (41° C.). Moreover, the polymer network is recyclable and re-processable, since the DA reaction is thermally reversible. The SMP of the present invention is well suited for numerous applications, especially in medical devices, given their excellent shape memory performance, tunable materials properties, body temperature-based stimulus, biocompatibility, and potential for biodegradation and resorption.

Oligomeric substances which contain one or more (meth)acryloyl functional groups as well as two or more amide functional groups are useful as components of compositions which may be cured using actinic irradiation to provide polymeric articles.

Provided is a lactic acid-based block copolymer which is biodegradable while having excellent mechanical properties.

Provided are polysiloxane structure-containing rubber particles and composite particles having a high dispersibility and degradability; and production methods thereof. The rubber particles are comprised of a copolymer having a polyester structure and an organopolysiloxane structure, wherein the copolymer is a hydrosilylation crosslinked product of (A) a polyester having at least two aliphatic unsaturated groups per molecule; and (B) an organohydrogenpolysiloxane having at least two silicon atom-bonded hydrogen atoms per molecule. The composite particles are those with the surfaces of these rubber particles being coated with polyorganosilsesquioxane or silica.