Disclosed in the present disclosure is a biodegradable amphiphilic polymer containing disulfide in the side chain, a self-crosslinked polymeric vesicle thereof and an application in the targeted therapy of lung cancer. The polymer is obtained by an activity-controllable ring-opening polymerization based on a cyclic carbonate monomer containing a functional group of dithiolane ring, which has a controllable molecular weight and a narrow molecular weight distribution, and does not require processes of protection and deprotection; the polymer obtained by the ring-opening polymerization of the cyclic carbonate monomer of the present disclosure has biodegradability and can be used to control the drug release system, the prepared lung cancer-targeted reduction-sensitive reversibly-crosslinked polymeric vesicle as a nanomedicine carrier supports stable long circulation in vivo. However, it is highly enriched in lung cancer tissues, enter cells efficiently, and rapidly decrosslinks in the cells to release drugs, so as to kill cancer cells with high potency and specificity and inhibit the growth of tumor effectively without causing toxic and side effects.

In one aspect, the present invention encompasses compositions of sustainable polycarbonate polymers, methods of producing such polymers, and methods for evaluating whether certain constituents of a polymer chain are derived from biomass or a fossil carbon source.

A phase difference film and a circularly polarizing film each achieve suppressed coloration when viewed from the front direction, a smaller difference in tint between views from the front direction and the oblique direction, and suppressed image unevenness, where the film is applied to an image display panel, in particular, an organic EL panel; as well as an image display device including the circularly polarizing film. The phase difference film includes optically anisotropic layers A and B, in which a retardation RthA of layer A in the thickness direction at a wavelength of 550 nm is larger than 0, layer A exhibits predetermined optical properties, a retardation RthB of layer B in the thickness direction at a wavelength of 550 nm is smaller than 0, layer B satisfies predetermined optical properties, and the angle formed between a slow axis of the optically anisotropic layers A and B is 9010.

A process for preparing a phosphorus-functional polyethercarbonate polyol, comprising reacting a polyethercarbonate polyol having unsaturated groups with a phosphorus-functional compound of formula (Ia):

##STR00001##

wherein X=O or S; and wherein R.sup.1 and R.sup.2 are selected from the group consisting of C1-C22 alkyl, C1-C22 alkoxy, C1-C22 alkylsulfanyl, C6-C70 aryl, C6-C70 aryloxy, C6-C70 arylsulfanyl, C7-C70 aralkyl, C7-C70 aralkyloxy, C7-C70 aralkylsulfanyl, C7-C70 alkylaryl, C7-C70 alkylaryloxy, C7-C70 alkylarylsulfanyl, or wherein R.sup.1 and R.sup.2 are bridged to one another directly and/or via heteroatoms and are selected from the group consisting of C1-C22 alkylene, oxygen, sulfur, and NR.sup.5, wherein R.sup.5 is hydrogen, C1-C22 alkyl, C1-C22 acyl, C7-C22 aralkyl, or C6-C70 aryl radical. A process for preparing a phosphorus-functional polyurethane polymer is disclosed. Phosphorus-functional polyethercarbonate polyol, phosphorus-functional polyurethane polymer, flame-retardant adhesion promoter, filler-activator, flame retardant, flame-retardant coating, foam, sealing compound, thermoplastic, thermoset, rubber, and a moulded body are disclosed.

Embodiments of the invention are directed to a macromolecular chemotherapeutic. A non-limiting example of the macromolecular chemotherapeutic includes a block copolymer. The block copolymer can include a water-soluble block, a cationic block, and a linker, wherein the linker is connected to the water-soluble bock and the charged block.

A resin formulation that can be cured thermally or by light, where the cured resin is an amorphous, thermoset polymer.

Provided is a diol compound of the following Chemical Formula 1, a polycarbonate comprising the diol compound, and a method of producing the polycarbonate: ##STR00001##

A bioflexible elastomer intestinal anastomosis stent based on a PTMC-b-PEG-b-PTMC copolymer, and a preparation method. Biocompatible degradable polymer medical materials, i.e., PTMC and PEG, are selected, an electrostatic spinning method is used for preparation, the size of an anastomosis tube can be adjusted according to the size of a human lumen, and the anastomosis tube is designed to not only be suitable for an anastomat of the small intestines and large intestines, but also suitable for an anastomotic and pre-supported lumen anastomat of an esophagus, artery, vein, etc. The anastomosis tube prepared has a thin wall and excellent elasticity, and in order to facilitate suturing by a doctor during a clinical surgical operation, the anastomosis tube is innovatively and seamlessly sleeved outside a plant cellulose tube having high hardness.

A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.

The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.