Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. (I), (II).

Compounds of the general structural formula (I) and (II) and use of the compounds and salts and hydrates thereof, as therapeutic agents are disclosed. Treatable diseases and conditions include cancers, inflammatory diseases and conditions, and immunodeficiency diseases. (I), (II).

A seating structure includes a base, a seat supported by the base, and a backrest supported by the base. The backrest includes a rear backrest section and a front backrest section coupled to the rear backrest section to define a gap therebetween. The gap extends around at least part of a perimeter of the backrest. The backrest further includes a fabric layer covering the front backrest section. A portion of the fabric layer is received in the gap.

A seating structure includes a base, a seat supported by the base, and a backrest supported by the base. The backrest includes a rear backrest section and a front backrest section coupled to the rear backrest section to define a gap therebetween. The gap extends around at least part of a perimeter of the backrest. The backrest further includes a fabric layer covering the front backrest section. A portion of the fabric layer is received in the gap.

The present application provides a cushion having a core layer and a quilt support/comfort layer. The core layer may comprise innersprings, foams, air cells, or combinations thereof. The support/comfort layer comprises a sleep layer that simulates a conventional quilted fabric layer. The sleep layer includes a thick, comfort fabric and a backing fabric, which backing fabric may be the same as the thick, comfort fabric. The sleep layer is formed by coupling the thick, comfort fabric to the backing fabric to form a plurality of individual pockets in which micro spring coils are placed. The micro spring coils have less uncompressed height than conventional innerspring coils. The sleep layer coupling is formed by spot coupling without using a metal needle to stitch the layers together. In other words, the spot coupling may comprise an adhesive or weld.

The present application provides a cushion having a core layer and a quilt support/comfort layer. The core layer may comprise innersprings, foams, air cells, or combinations thereof. The support/comfort layer comprises a sleep layer that simulates a conventional quilted fabric layer. The sleep layer includes a thick, comfort fabric and a backing fabric, which backing fabric may be the same as the thick, comfort fabric. The sleep layer is formed by coupling the thick, comfort fabric to the backing fabric to form a plurality of individual pockets in which micro spring coils are placed. The micro spring coils have less uncompressed height than conventional innerspring coils. The sleep layer coupling is formed by spot coupling without using a metal needle to stitch the layers together. In other words, the spot coupling may comprise an adhesive or weld.

A chair assembly includes a back support arrangement including a back support arrangement, a seat support arrangement and a four-bar arrangement that includes a rearward end and a forward end that is adjustable between a raised and lowered positions, and an arm rest assembly adapted to support the arm of a seated user thereon and supported on the forward end of the four-bar arrangement, wherein the rearward end of the four-bar arrangement is pivotably supported from an arm support structure for pivotable movement about a substantially vertical pivot axis such that the forward end of the four-bar arrangement is moveable between a first position and second position located laterally outward from the first position, and wherein the substantially vertical pivot axis is located forwardly of a rearmost edge of an upwardly-facing surface of the seat support arrangement.

A chair control assembly includes a base structure having first and second pivot points spaced from one another, a seat support structure coupled to the first pivot point, a back support structure coupled to the second pivot point and adapted to move between first and second positions, wherein the base structure does not move as the back support structure moves between the first and second positions, and a control link pivotably coupled to the seat support structure for rotation about a third pivot point and pivotably coupled to the back support structure for rotation about a fourth pivot point, wherein the third pivot point is rearward of the fourth pivot point when the back support structure is in the upright position, and the third pivot point moves forward relative to the fourth pivot point as the back support structure moves from the upright to reclined positions.

The present disclosure provides a support device including a body interface layer resting against a user's body, a core adjacent the body interface layer with a plurality of independently acting micro coils surrounded by an enclosure layer, a stabilizing layer more rigid than the enclosure layer and the body interface layer, and an outer layer adjacent the stabilizing layer and which rests against an external surface such as a seat back when the device is in use. The body interface layer includes a curvilinear or parabolic profile with its inflection point toward a central region of the device and tapering toward lateral ends thereof. The body interface layer is thickest toward its intermediate portion which aligns with a central row of the spiral biasing devices, the body interface layer thinner outer intermediate regions aligning with outer spiral biasing device rows, providing for a consistently distributed pressure against the body.

The present disclosure provides a support device including a body interface layer resting against a user's body, a core adjacent the body interface layer with a plurality of independently acting micro coils surrounded by an enclosure layer, a stabilizing layer more rigid than the enclosure layer and the body interface layer, and an outer layer adjacent the stabilizing layer and which rests against an external surface such as a seat back when the device is in use. The body interface layer includes a curvilinear or parabolic profile with its inflection point toward a central region of the device and tapering toward lateral ends thereof. The body interface layer is thickest toward its intermediate portion which aligns with a central row of the spiral biasing devices, the body interface layer thinner outer intermediate regions aligning with outer spiral biasing device rows, providing for a consistently distributed pressure against the body.