A method for filtering a gas comprises passing a gas through a compartment of a filter assembly, the filter assembly comprising: an inlet opening; a first outlet opening; a casing comprising polymeric film and bounding the compartment, the compartment communicating with the inlet opening and the first outlet opening; and a first filter at least partially disposed within the compartment. The method further comprising forming a first seal across a first section of the casing at a location between the inlet opening and the first filter to form a first sub-compartment within the casing and severing the casing at a first location.

Systems and methods for the efficient agitation of tissue samples. A device may include a plurality of chambers that each receives samples therein. The plurality of chambers may be uniformly spaced with respect to a least one dimension, to form a one dimensional or two dimensional array. Each of the chambers may include an opening and an agitator device in fluid contact with the sample disposed within the chamber. The agitator devices may include a micromotor which provides rotational motion to a shaft and an impeller fixed to the shaft such that the impeller and the shaft rotate together upon provision of the rotational motion by the micromotor. The system may include an electrical energy source electrically coupled to the plurality of micromotors to rotate the impellers sufficient to agitate the sample as required for a particular activity (e.g., homogenization, lysis).

The present invention relates to a bioreactor for cell culture. According to an embodiment of the present invention, vibration is provided to a cell culture solution (solution) to facilitate cell separation, and, since the vibration is transmitted to the entire cell culture solution without dead zones, cell separation efficiency is excellent.

A cell-culture bioreactor operative to provide real-time reactor management in the fields of stir control, sparge control, and heat management responsively to wireless sensor feedback to optimize operating conditions to maximize cell-culture yield; and a bioreactor comprising: a vessel, having an open top; a headplate, configured to seal the vessel's open top; and a stirring device, comprising at least two independent stirring elements; wherein each of the stirring elements is configured to independently stir media accommodated within the vessel.

A cell culture container comprising a base section and a compressible wall element. The base section includes a substantially planar rigid base plate. The compressible wall element extends from the base section in an axial direction and defines an internal volume of the cell culture container. The compressible wall element is compressible in the axial direction. There is also disclosed a bioreactor that includes the cell culture container.

A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.

A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.

A bioproduction mixer control system includes a mixing compartment having a biological fluid and a mixing element; a sensor in communication with the mixing compartment, the sensor configured to detect an environmental condition within the mixing compartment; and an integrated control unit. The integrated control unit includes a memory for storing the environmental condition, sensor information relating to the sensor, and process workflow information; a user interface comprising a display depicting a bioproduction workspace, wherein the bioproduction workspace comprises a process workflow title and a plurality of bioprocess modules; and a central processing unit in electronic communication with the sensor, memory and user interface.

The invention relates to a fermenter vessel (1) of a biogas plant, having at least one height-adjustable agitator (8), wherein the agitator (8), in the fermenter vessel (1), is guided with a guide element (17) on a guide rail (9) oriented approximately vertically in a vertical axis direction and is held in height-adjustable fashion by means of a traction cable (10). According to the invention, a traction force measuring device (22; 25) is provided for directly and/or indirectly measuring the traction force on the traction cable (10) in accordance with a cable tension, such that, by means of the traction force measuring device (22; 25), in the case of a preferably controlled height adjustment of the agitator (8), varying traction force measurement signals are generated in accordance with varying traction forces and are supplied to an evaluation device (20).

A bioreactor for growing micro-organisms in a reaction mixture including a reaction medium and micro-organisms. The bioreactor includes a first reaction chamber, a second reaction chamber and means for connecting the first reaction chamber to the second reaction chamber. The first reaction chamber has first volume for containing first number of micro-organisms, a first input for providing reaction mixture thereto, and a first output for removing excess gases therefrom. The second reaction chamber, arranged downstream from first reaction chamber, has a second volume for containing a second number of micro-organisms, a second input for providing gases thereto, and a second output for removing reaction mixture therefrom. The means for connecting is the sole input for allowing the reaction mixture to flow from the first reaction chamber to the second reaction chamber and for gases to flow from the second reaction chamber to the first reaction chamber.