The invention relates to a liquid supply interface for a cell culture system for supplying cell cultures found in different cell culture containers with a nutrient medium, wherein the liquid supply interface comprises: a housing defining a flow area; a first connection formation for the liquid-transferring connection of a first fluid line to the housing; a second connection formation formed separately from the first for the liquid-transferring connection of a second fluid line to the housing; a third connection formation formed separately from the first two for the liquid-transferring connection of the housing to a third fluid line; a coupling formation formed separately from the connection formations, which is formed for the producible and detachable liquid-transferring coupling contact according to the operation, with a corresponding counter-coupling formation of a cell culture container.

The invention relates to a liquid supply interface for a cell culture system for supplying cell cultures found in different cell culture containers with a nutrient medium, wherein the liquid supply interface comprises: a housing defining a flow area; a first connection formation for the liquid-transferring connection of a first fluid line to the housing; a second connection formation formed separately from the first for the liquid-transferring connection of a second fluid line to the housing; a third connection formation formed separately from the first two for the liquid-transferring connection of the housing to a third fluid line; a coupling formation formed separately from the connection formations, which is formed for the producible and detachable liquid-transferring coupling contact according to the operation, with a corresponding counter-coupling formation of a cell culture container.

The invention relates to a liquid supply interface (62, 62, 62, 62) for a cell culture system for supplying cell cultures found in different cell culture containers (10, 10, 10) with a nutrient medium, wherein the liquid supply interface (62, 62, 62, 62) comprises: a housing (68) defining a flow area (72); a first connection formation (76) for the liquid-transferring connection of a first fluid line (84) to the housing (68); a second connection formation (78) formed separately from the first for the liquid-transferring connection of a second fluid line (88) to the housing (68); a third connection formation (80) formed separately from the first two for the liquid-transferring connection of the housing (68) to a third fluid line; a coupling formation (64, 66) formed separately from the connection formations (76, 78, 80), which is formed for the producible and detachable liquid-transferring coupling contact according to the operation, with a corresponding counter-coupling formation (38, 40) of a cell culture container (10, 10, 10).

A system for processing samples from a body of fluid. The system includes one or more sample bottles for acquiring a sample from the body of fluid. Each sample bottle initially retains a pre-filling fluid. Each sample bottle includes a fluidic inlet port and a bottle outlet port. Each sample bottle has an inlet check valve coupled to the fluidic inlet port, the inlet check valve configured to allow fluid from the body of fluid into a sample bottle via the fluidic inlet port when the pressure difference between the body of fluid and fluid within the sample bottle reaches a threshold. The system further includes at least one pump, the bottle outlet port of each sample bottle selectively coupled to the at least one pump via a different control valve. The at least one pump is configured, in a first configuration, to remove prefilling fluid from each selected sample bottle such that, for each selected sample bottle, the pressure difference threshold is reached and a sample from the body of fluid is acquired.

Disclosed herein are a retrofit device adapted to upgrade bioreactor systems that require at least partially manual addition of liquids, and a method for using the retrofit device with the bioreactor systems. The retrofit device automatically adds the liquids by weight to the bioreactor vessels according to a protocol or procedure. The retrofit device also includes a valve that in the event of power cut-off automatically closes to prevent unintentional addition of liquids.

The present disclosure relates to a quantitative, sterile and disposable automatic cell sampling device and method. The automatic cell sampling device includes a sampling container, a pump, a sterile filter, a control valve, a first conduit, and a second conduit. A receiving cavity is formed in an interior of the sampling container, and a first interface and a second interface are formed in a top portion of the sampling container for achieving a maximum sampling capacity of the sampling container. One end of the first conduit is connected to the first interface, and the other end thereof is connected to a cell based drug production device through the pump. The control valve is installed in a middle of the first conduit. The second conduit is connected between the second interface and the sterile filter, and is configured for discharging and supplementing sterile air in the sampling container.

A cell seeding apparatus of the present disclosure includes a dropping device that drops a liquid droplet of a cell suspension into a cell culture vessel having a measurement electrode and a reference electrode disposed on a bottom surface, an imaging device that is provided in the dropping device and that images the bottom surface to generate an image, and an information processing device that detects positions of the measurement electrode and the reference electrode based on the image and that decides, based on detection information, a dropping position of the liquid droplet at which cells are to be placed on the measurement electrode without placing the cells on the reference electrode.

A sampling system includes a graduated sampling chamber configured for fluid connection to a sample source, a pump device configured for fluid connection with the sampling chamber, and a sterile air filter intermediate the pump device and the sampling chamber, wherein the pump device is selectively actuatable to draw a volume of fluid from the sample source into the sampling chamber.

The present invention provides a self-draining well plate cassette and an automated system for cultivating C. elegans comprising a housing, a well plate assembly having at least two of the self-draining well plate cassettes, a liquid dispensing assembly operated by a first three axes positioner, a wash and imaging assembly operated by a second three axis positioner, a reagent assembly, a pipette tip holder, and a controller. The present invention further provides a method of using the above-described system to cultivate C. elegans.

An automatic liquid handling device comprises: a deck, located at the bottom, for accommodating one or more racks; a pipetting device, placed above the deck, capable of three-dimensional movement by an actuator, for aspirating and dispensing samples by coupling pipette tips to a probe; a tip optical system, mounted on the deck, for imaging a cell mixture aspirated into the pipette tip from a sample container at the counting position; a cooling module that holds a sample container accommodating a cell mixture containing cells or cell clusters, to keep the cell mixture cool; and a control module for calculating the number of cells based on the taken image of the cell mixture aspirated into the pipette tip and controlling the operation of the pipetting device according to a pre-programmed method, wherein the control module calculates the number of cells on the basis of the taken image of the pipette tip.