Disclosed are a cell evaluation device, a cell evaluation method, and a non-transitory computer readable recording medium recorded with a cell evaluation program capable of evaluating individual cells in a cell image obtained by imaging a cell group with high accuracy. The cell evaluation device includes an image acquisition unit 30 that acquires a cell image obtained by imaging a cell group; a cell evaluation unit 32 that specifies an evaluation target cell and peripheral cells around the evaluation target cell in the cell group and evaluates the evaluation target cell based on evaluation results of the peripheral cells.

This invention provides novel tools for surgery on single cells and substrates/devices for delivery of reagents to selected cells. In certain embodiments the substrates comprise a surface comprising one or more orifices, where nanoparticles and/or a thin film is deposited on a surface of said orifice or near said orifice, where the nanoparticles and/or a thin film are formed of materials that heat up when contacted with electromagnetic radiation. In certain embodiments the pores are in fluid communication with microchannels containing one or more reagents to be delivered into the cells.

The present disclosure provides systems and methods for detecting the presence of colonies on agar plates. The systems and methods are suitably useful for evaluating the presence of a contaminant (e.g., bacterial, fungal, etc.) in a sample, such as a raw material or component of a pharmaceutical composition, by analyzing whether the samples produce colonies on an agar plate. The systems utilize a lighting arrangement to increase the accuracy of the analysis, and in embodiments, include the use of artificial intelligence as part of an automated process.

Provided is a liquid feeding device which can improve collection efficiency of fine particles on an individual particle basis while improvement of workability is realized.

A liquid feeding device includes: an introduction portion disposed on one end portion of the liquid feeding device, and configured to introduce a liquid into a closed space; a discharge portion disposed on another end portion of the liquid feeding device, and configured to discharge the liquid supplied into the closed space; and an upper wall provided so as to oppose the upper surface of the chip, and configured to define the closed space. The upper wall has an inclined surface which is provided such that a gap formed between the inclined surface and the chip is reduced from an introduction portion side toward a discharge portion side.

The invention relates to a method for producing microalgae on a support (14) that is movably mounted essentially in an aqueous medium contained in a tank (12), said method comprising a succession of phases in which the microalgae developing on the support (14) are exposed to sunlight and phases in the shade, the light intensity received in the shade being less than 50% of the average light intensity received during the sunlight exposure phases. The total length of the shade phases is more than 50% longer than the total length of the sunlight exposure phases.

A light supplementation and thermal insulation device for microalgae pipeline cultivation and a method for microalgae pipeline cultivation is provided. The light supplementation and thermal insulation device has a combined light conversion film body, fixing parts located at an upper end and a lower end of the combined light conversion film body, and lifting systems; the combined light conversion film body comprises a bottom opaque film, a middle reflective film, and an upper light conversion film; the bottom opaque film, the middle reflective film, and the upper light conversion film are fixed together as a whole by the fixing parts at the upper end and the lower end; the lifting systems are connected to the fixing parts at the upper end. It solves the problem of difficult light supplementation during the daytime in microalgae pipeline cultivation and also addresses the issue of thermal insulation during the nighttime.

Provided is an apparatus for observing cells including a movable image photographing device, which includes a light-transmitting culture vessel in which a plurality of light-transmitting attachment members are irregularly arranged, wherein a plurality of cells are attached to and cultured on the plurality of light-transmitting attachment members, an image photographing device movable within the housing and configured to photograph the plurality of cells attached to and cultured on the plurality of light-transmitting attachment members irregularly arranged in the light-transmitting culture vessel, and a light source irradiating light to the plurality of cells attached to and cultured on the plurality of light-transmitting attachment members irregularly arranged in the light-transmitting culture vessel, to allow the image photographing device to photograph each of the plurality of cells attached to and cultured on the plurality of light-transmitting attachment members irregularly arranged in the light-transmitting culture vessel, to be recognizable. Accordingly, not only an image of cells is obtained when a device for obtaining an image of cells is in a stopped state, but also an image of cells cultured in an area where an image of cells is difficult or impossible to obtain is obtained when the device for obtaining an image of cells is in a stopped state, thereby obtaining an image of cells cultured in all areas, not in a limited area, so that observation efficiency may be greatly improved.

A photo-bioreactor and method of operating are described. The photo-bioreactor includes a reactor vessel arranged to contain a fluid medium within which bio-material is grown, and at least one light-emitting rod extending into the reactor vessel, wherein the light-emitting rod has an elongate tubular member characterized by a length along a longitudinal axis and a width along an axis normal to the longitudinal axis, and designed with an outer wall that encloses one or more light-emitting devices arranged along the longitudinal axis, the outer wall being transparent to at least part of the light emitted by the one or more light-emitting devices into the reactor vessel. The photo-bioreactor further includes a drive system coupled to the elongate tubular member, and operatively configured to rotate the light-emitting rod about the longitudinal axis within reactor vessel, and circulate the fluid medium through the reactor.

Disclosed are a cell evaluation device, a cell evaluation method, and a non-transitory computer readable recording medium recorded with a cell evaluation program capable of evaluating individual cells in a cell image obtained by imaging a cell group with high accuracy. The cell evaluation device includes an image acquisition unit 30 that acquires a cell image obtained by imaging a cell group; a cell evaluation unit 32 that specifies an evaluation target cell and peripheral cells around the evaluation target cell in the cell group and evaluates the evaluation target cell based on evaluation results of the peripheral cells.

A bioreactor system includes a reactor tank, a liquid input line in fluid communication with the reactor tank to provide a liquid medium to an interior of the reactor tank, a gas input line in fluid communication with the reactor tank to provide a gas to the interior of the reactor tank, and an agitator positioned in the reactor tank. The bioreactor system includes a sight glass disposed on a wall of the reactor tank. The sight glass is positioned at a first height from a bottom of the reactor tank. The first height lower is than a second height indicative of a maximum fill height for the liquid medium within the reactor tank. The sight glass is adapted to interact with light-based measurement technologies.