The invention relates to logic-gate-based Type II or Type V CRISPR-Cas constructs and methods for modifying gene expression using the CRISPR-Cas constructs and CRISPR-Cas effector proteins.

Described are compounds and compositions for transdifferentiation of glioblastoma cells to antigen presenting cells. Methods of using the compounds and compositions to treat glioblastoma and to induce an immune response against a glioblastoma are also described.

Described are compounds and compositions for transdifferentiation of glioblastoma cells to antigen presenting cells. Methods of using the compounds and compositions to treat glioblastoma and to induce an immune response against a glioblastoma are also described.

The present disclosure includes antibodies that specifically bind integrin alpha 11 beta 1 (α11β1), as well as methods of making and using such antibodies.

The present disclosure includes antibodies that specifically bind integrin alpha 11 beta 1 (α11β1), as well as methods of making and using such antibodies.

Provided are a 4-ureido-5-carboxyl-imidazole-amide hydrolase and use thereof, particularly use in the treatment of gout.

Disclosed herein are cartridges for transfecting cells and/or generating clonal populations of cells comprising: a) a first compartment configured for performing cell transfection, wherein the first compartment comprises a first inlet configured for introduction of a cell sample; b) a second compartment configured for performing cell selection, wherein an inlet of the second compartment is operably coupled to an outlet of the first compartment, and wherein the second compartment further comprises at least one optically-transparent wall and an outlet that is operably coupled to an intermediate cell removal port; and c) a third compartment configured for performing cell expansion, wherein an inlet of the third compartment is operably coupled to the outlet of the second compartment.

The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.

The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.

The present disclosure relates to a method for constructing a producer cell and the producer cell obtained by the method, wherein the producer cell is for producing a retroviral vector carrying a nucleic acid fragment of interest.