The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided.

This invention concerns a new method for differentiating oral neuroectodermal stem cells (CSO-NE), in particular human gingival neuroectodermal stem cells (CSGh), into oligodendrocytes (OL), and their use in the repair of the nervous system, in particular of head injuries.

The present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell from a surface ectoderm-derived cell. More specifically, the present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell, comprising introducing PAX6, KLF4, and OCT4 into a surface ectoderm-derived cell, such as an oral mucosal epithelial cell, and a corneal epithelioid cell induced by the method.

A medium composition for inducing differentiation of taste bud organoids derived from the anterior tongue epithelium, a method for producing taste bud organoids, a taste bud organoid derived from the anterior tongue epithelium, and a method for screening a tastant using the same, wherein the medium composition for inducing differentiation of taste bud organoids derived from the anterior tongue epithelium and the method for producing taste bud organoids using the same may efficiently form the taste bud organoids from tongue epithelial tissue and may control their differentiation into specific types of taste cells. In addition, the taste bud organoids derived from the anterior tongue epithelium formed by the method may maximize the expression of markers for various taste buds and cells that make up taste buds to express salty taste detection proteins, so that they may be used in various fields such as cell sensors and tastant screening.

The present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell from a surface ectoderm-derived cell. More specifically, the present invention relates to a method for inducing a keratin 12-positive corneal epithelioid cell, comprising introducing PAX6, KLF4, and OCT4 into a surface ectoderm-derived cell, such as an oral mucosal epithelial cell, and a corneal epithelioid cell induced by the method.