Compositions, methods, and kits are disclosed directed at haptens, immunogens and immunoassays for oxycodone and metabolites thereof. The compounds are exemplified by compounds of the Formula I. The method comprises providing in combination in a medium (i) a sample suspected of containing oxycodone and/or oxycodone metabolites, a compound of the Formula I wherein R.sup.4 or R.sup.5 is a label, and an antibody for oxycodone or a metabolite thereof. The medium is examined for the presence of a complex comprising the labeled compound of Formula I where the presence of such as complex indicates the presence of oxycodone or oxycodone metabolite in the sample.

The present invention discloses a nitrogen-sulfur co-doped Ti.sub.3C.sub.2-MXene nanosheet and a preparation method and application thereof. Ti.sub.3C.sub.2-MXene is obtained by etching ternary layered carbides of MAX phase through hydrofluoric acid; and then, the nitrogen-sulfur co-doped Ti.sub.3C.sub.2-MXene nanosheet is synthesized by a simple one-step method by taking thiourea as a heteroatom source. The nitrogen-sulfur co-doped Ti.sub.3C.sub.2-MXene nanosheet has a unique two-dimensional layered structure, large specific surface area and abundant heteroatomic catalytic activity sites so that the material presents excellent peroxidase-like activity. The method of the present invention can successfully dope two elements of nitrogen and sulfur in one step on Ti.sub.3C.sub.2-MXene, and can effectively overcome the tedious problem of a step-by-step doping step and the secondary pollution problem of different doping sources to endow peroxidase-like activity for Ti.sub.3C.sub.2-MXene.

The present invention discloses a nitrogen-sulfur co-doped Ti.sub.3C.sub.2-MXene nanosheet and a preparation method and application thereof. Ti.sub.3C.sub.2-MXene is obtained by etching ternary layered carbides of MAX phase through hydrofluoric acid; and then, the nitrogen-sulfur co-doped Ti.sub.3C.sub.2-MXene nanosheet is synthesized by a simple one-step method by taking thiourea as a heteroatom source. The nitrogen-sulfur co-doped Ti.sub.3C.sub.2-MXene nanosheet has a unique two-dimensional layered structure, large specific surface area and abundant heteroatomic catalytic activity sites so that the material presents excellent peroxidase-like activity. The method of the present invention can successfully dope two elements of nitrogen and sulfur in one step on Ti.sub.3C.sub.2-MXene, and can effectively overcome the tedious problem of a step-by-step doping step and the secondary pollution problem of different doping sources to endow peroxidase-like activity for Ti.sub.3C.sub.2-MXene.

Apparatus and methods for determining the blood glucose concentration of a patient are disclosed A saliva glucose measurement strip is used in conjunction with a glucose measurement device to measure an electrochemical signal of a saliva sample and the measured electrochemical signal is correlated to a blood glucose convention.

The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.

The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.

System and Method for measuring the growth of a bacterial culture and its response to one or more antimicrobials using measurement of mass of individual microbes. Methods include periodic sampling, determining change in mass and concentration, and comparing growth rates of cultures in nutrient broth vs. mixtures containing various antibiotic mixtures. A number of antimicrobials can be compared in one measurement by multiplexing or using multiple sensors to measure in parallel. Growth and antibiotic efficacy can be assessed at low concentrations at the onset of growth, typically within 1 to 2 hours.

The claimed invention provides personalized glucose and insulin information to a user in need thereof. Non-invasive body fluid capture techniques utilize saliva to provide body levels of glucose and insulin as well as optional pharmaceutical ingestion coordinated over time. Saliva captured on cellulose strips are analyzed in real time using oxidation and aptamer conjugate hybridization together with traditional analytical chemistry techniques including liquid chromatography/mass spectrometry (LC/MS) and coordinated against time of pharmaceutical administration. By embracing the P4 (Participatory, Personalized, Predictive, and Preventive) health management method the patient can determine glucose and insulin related wellness levels and if a pharmaceutical is having the correct and desired effect for maximum therapeutic benefit.

The present invention relates to a kit for quantitative analysis of glycated hemoglobin (HbA1c), and the kit for quantitative analysis of HbA1c according to the present invention has excellent long-term stability of an enzyme reagent and thus has an effect of easily overcoming the disadvantages of the conventional reagents used in enzyme assays (e.g., storage, accuracy, portability, convenience of use, etc.).

The present invention relates to a kit for quantitative analysis of glycated hemoglobin (HbA1c), and the kit for quantitative analysis of HbA1c according to the present invention has excellent long-term stability of an enzyme reagent and thus has an effect of easily overcoming the disadvantages of the conventional reagents used in enzyme assays (e.g., storage, accuracy, portability, convenience of use, etc.).