Screening methods as well as kits for identifying modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family member proteins, such as HSD17B13, are provided. The methods comprise screening molecules for their capacity to modulate the HSD17B family member protein, including inhibiting the HSD17B family member protein, as measured by substrate depletion, product concentration from the HSD17B family member protein substrate conversion or NADH concentration, levels of labeled substrate, luciferin light emission, or combinations thereof. Inhibitors of HSD17B family member proteins identified through the screening methods may be used to treat liver diseases, disorders, or conditions in which the HSD17B family member protein plays a role.

Screening methods as well as kits for identifying modulators of hydroxysteroid (17-beta) dehydrogenase (HSD17B) family member proteins, such as HSD17B13, are provided. The methods comprise screening molecules for their capacity to modulate the HSD17B family member protein, including inhibiting the HSD17B family member protein, as measured by substrate depletion, product concentration from the HSD17B family member protein substrate conversion or NADH concentration, levels of labeled substrate, luciferin light emission, or combinations thereof. Inhibitors of HSD17B family member proteins identified through the screening methods may be used to treat liver diseases, disorders, or conditions in which the HSD17B family member protein plays a role.

In certain aspects, provided herein are methods and kits for detecting the presence of C. difficile in a biological sample. Also provided herein are methods of selecting of identifying a subject that would benefit from C. difficile treatment.

In certain aspects, provided herein are methods and kits for detecting the presence of C. difficile in a biological sample. Also provided herein are methods of selecting of identifying a subject that would benefit from C. difficile treatment.

The present disclosure provides a means for preventing or suppressing the leaching of a redox mediator constituting a reagent layer in a probe of an embedded biosensor, in particular, a means capable of improving preservation stability (durability) while maintaining glucose measurement sensitivity. The high molecular weight redox polymer according to the present disclosure is represented by general formula (A1), wherein X.sup.− represents an anionic species; L represents a linker; Poly represents a high molecular weight polymer; and R.sup.1 to R.sup.8 each independently represent a hydrogen atom or a substituent. The biosensor according to the present disclosure has a working electrode, a counter electrode, a reagent layer disposed on the working electrode, and a protective film covering at least the reagent layer, and the reagent layer contains an oxidoreductase that oxidizes or dehydrogenates the analyte and at least one high molecular weight redox polymer represented by general formula (A1).

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The present disclosure provides a means for preventing or suppressing the leaching of a redox mediator constituting a reagent layer in a probe of an embedded biosensor, in particular, a means capable of improving preservation stability (durability) while maintaining glucose measurement sensitivity. The high molecular weight redox polymer according to the present disclosure is represented by general formula (A1), wherein X.sup.− represents an anionic species; L represents a linker; Poly represents a high molecular weight polymer; and R.sup.1 to R.sup.8 each independently represent a hydrogen atom or a substituent. The biosensor according to the present disclosure has a working electrode, a counter electrode, a reagent layer disposed on the working electrode, and a protective film covering at least the reagent layer, and the reagent layer contains an oxidoreductase that oxidizes or dehydrogenates the analyte and at least one high molecular weight redox polymer represented by general formula (A1).

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Devices, systems, and methods are used for personalized monitoring of changes in metabolism as a function of external parameters such as food or physical exercise. More particularly, the present disclosure relates to electrochemical strips for detecting the amount of biomarker for fat metabolism, in particular, glycerol.

Devices, systems, and methods are used for personalized monitoring of changes in metabolism as a function of external parameters such as food or physical exercise. More particularly, the present disclosure relates to electrochemical strips for detecting the amount of biomarker for fat metabolism, in particular, glycerol.

The present description relates to methods for clinically assessing Parkinson's disease in a subject using protein biomarkers of erythrocyte-derived extracellular vesicles (EEV).

The present description relates to methods for clinically assessing Parkinson's disease in a subject using protein biomarkers of erythrocyte-derived extracellular vesicles (EEV).