The present invention provides novel compositions and methods for assessing the size of tandem repeat sequences, e.g., telomeres, within a genome, using specially designed Molecular Inversion Probes (MIPs) and reaction conditions.

Some embodiments described herein relate to new polymer coatings for surface functionalization and new processes for grafting pre-grafted DNA-copolymers to surface(s) of substrates for use in DNA sequencing and other diagnostic applications.

The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.

The present invention provides novel compositions and methods for assessing the size of tandem repeat sequences, e.g., telomeres, within a genome, using specially designed Molecular Inversion Probes (MIPs) and reaction conditions.

The present invention provides novel compositions and methods for assessing the size of tandem repeat sequences, e.g., telomeres, within a genome, using specially designed Molecular Inversion Probes (MIPs) and reaction conditions.

Some embodiments described herein relate to new polymer coatings for surface functionalization and new processes for grafting pre-grafted DNA-copolymers to surface(s) of substrates for use in DNA sequencing and other diagnostic applications.

The present invention relates to methods of providing sequence specificity to in situ genome imaging using triplex forming oligopaints.

The present invention relates to methods of providing sequence specificity to in situ genome imaging using triplex forming oligopaints.

The present invention provides novel methods for exponential amplification of labeled nucleic acids with high sensitivity and specificity. In one aspect, the invention includes a method for exponentially amplifying the signal of a fluorescently labeled primary click-amplifying FISH (clampFISH) probe. In another aspect, the invention includes a method for labeling a target nucleic acid in a sample. In yet another aspect, the invention includes a method for detecting a fluorescently labeled target nucleic acid in a sample. The present invention also provides a kit for use with the methods of the invention.