Patent classifications
C
CHEMISTRY; METALLURGY
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C12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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C12Y
ENZYMES
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205/00
Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
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C12Y205/01
transferring alkyl or aryl groups, other than methyl groups (2.5.1)
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C12Y205/01025
tRNA-uridine aminocarboxypropyltransferase (2.5.1.25)
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C12Y205/01025

DISCOVERY OF A URIDINE RNA MODIFICATION AND A PROPOSED BIOSYNTHESIS PATHWAY
20250326783 · 2025-10-23 ·

The present disclosure relates to the identification of a novel nucleoside modification, referred to herein as anhydride U, present in tRNA molecules within the cell. The present disclosure further relates to the enzymatic and chemical production of anhydride U as well as methods for detecting and regulating the presence of anhydride U within the cell.