The present invention relates to silica aerogels with a high to very high loading (55-90% w/w) of encapsulated biocidal and/or biorepellant compounds and very low thermal conductivity and to methods of making and using such aerogels in anti-fouling compositions, which are especially suitable for coatings (marine paints, coatings, sealants, lacquers, wood protection or similar controlled leaching systems) that are naturally exposed to humid conditions and/or water, including sea water, and thus prone to fouling.

The present invention relates to silica aerogels with a high to very high loading (55-90% w/w) of encapsulated biocidal and/or biorepellant compounds and very low thermal conductivity and to methods of making and using such aerogels in anti-fouling compositions, which are especially suitable for coatings (marine paints, coatings, sealants, lacquers, wood protection or similar controlled leaching systems) that are naturally exposed to humid conditions and/or water, including sea water, and thus prone to fouling.

The present invention relates to silica aerogels with a high to very high loading (55-90% w/w) of encapsulated biocidal and/or biorepellant compounds and very low thermal conductivity and to methods of making and using such aerogels in anti-fouling compositions, which are especially suitable for coatings (marine paints, coatings, sealants, lacquers, wood protection or similar controlled leaching systems) that are naturally exposed to humid conditions and/or water, including sea water, and thus prone to fouling.

The present invention relates to biocidal agents designed to protect industrial products against microbial, bacterial, fungal and algal infections. In particular, the present invention relates to co-crystals containing 3-iodopropynyl butylcarbamate (IPBC) and to compositions containing said co-crystals which possess improved physical, chemical and workability properties compared with the use of IPBC.

The decrease in soybean rust control using fungicide mixtures (DMAs+QoIs) reached very low levels for the harvest of 2012/13 (an average of 37% for the three main mixtures). This decrease is due to a decrease in Pp sensitivity to individual DMIs and QoIs, and mixtures thereof. Anti-resistance strategies have not been introduced in Brazil for preventing/delaying the development of resistance of the fungus that is the casual agent of rust (Phakopsora pachyrhizi) in soybean [plant form the family Fabaceae, Glycine max (L.) Merr.] and of the fungus that is the casual agent of yellow leaf spot (Drechslera tritici-repentis) in wheat [plant of the family Triticea, Triticum aestivum L.], as well as other disease complexes that attack the main crop plants in Brazil, such as corn, beans, cotton, inter alia. By means of said method it is possible to recover the efficiency of several mixtures (DMI+QoI and QoI+SDHI) due to a decrease in fungal sensitivity. The methods described by the present invention seek to increase the effective useful life of fungicides and increase grain yield.

The decrease in soybean rust control using fungicide mixtures (DMAs+QoIs) reached very low levels for the harvest of 2012/13 (an average of 37% for the three main mixtures). This decrease is due to a decrease in Pp sensitivity to individual DMIs and QoIs, and mixtures thereof. Anti-resistance strategies have not been introduced in Brazil for preventing/delaying the development of resistance of the fungus that is the casual agent of rust (Phakopsora pachyrhizi) in soybean [plant form the family Fabaceae, Glycine max (L.) Merr.] and of the fungus that is the casual agent of yellow leaf spot (Drechslera tritici-repentis) in wheat [plant of the family Triticea, Triticum aestivum L.], as well as other disease complexes that attack the main crop plants in Brazil, such as corn, beans, cotton, inter alia. By means of said method it is possible to recover the efficiency of several mixtures (DMI+QoI and QoI+SDHI) due to a decrease in fungal sensitivity. The methods described by the present invention seek to increase the effective useful life of fungicides and increase grain yield.

The present invention relates to pharmaceutical combinations comprising aminoacetonitrile derivatives and anticancer compounds. Further, the present invention relates to these pharmaceutical combinations for use in the treatment of cancer.

The present invention relates to N-acylimino compound of formula (I): ##STR00001##
wherein X is O or S, in particular O; Y is a single bond, O, S or NR.sup.5; Het is a 5 or 6 membered carbon-bound or nitrogen-bound heterocyclic ring, W.sup.1-W.sup.2-W.sup.3-W.sup.4 represents a carbon chain group connected to N and C═N, and thus forming a saturated, unsaturated, or partially unsaturated 5 or 6 membered nitrogen containing heterocycle, wherein W.sup.1, W.sup.2, W.sup.3 and W.sup.4 each individually represent CR.sup.vR.sup.w; R.sup.1, R.sup.2 may be hydrogen, halogen, etc.; R.sup.3 may be hydrogen, CN, C.sub.1-C.sub.6-alkyl, etc.; R.sup.4 may be of hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkinyl, C.sub.3-C.sub.8-cycloalkyl, Q-phenyl, Q′-O-phenyl, Q′-S-phenyl, where the phenyl ring is optionally substituted with one or more, e.g. 1, 2, 3, 4 or 5 identical or different substituents R.sup.10, and the moieties Q-Het.sup.#, Q′-O-Het.sup.# and Q′-S-Het.sup.# where Het# represents a heterocyclic radical and where Q and Q′ are C.sub.1-C.sub.6-alkandiyl, C.sub.2-C.sub.6-alkendiyl, or C.sub.2-C.sub.6-alkyndiyl, and where Q may also be a single bond; R.sup.3 and R.sup.4 together may also may also a bivalent radical, selected from the group consisting of C.sub.2-C.sub.5-alkandiyl, C.sub.2-C.sub.5-alkendiyl, Q″-C.sub.1-C.sub.4-alkandiyl and Q″-C.sub.2-C.sub.4-alkendiyl, where Q″ is O or S. The invention also relates to the use of the N-acylimino heterocyclic compounds, their stereoisomers, their tautomers and their salts, for combating invertebrate pests. Furthermore the invention relates also to methods of combating invertebrate pests, which comprises applying such compounds.

The present invention relates to N-acylimino compound of formula (I): ##STR00001##
wherein X is O or S, in particular O; Y is a single bond, O, S or NR.sup.5; Het is a 5 or 6 membered carbon-bound or nitrogen-bound heterocyclic ring, W.sup.1-W.sup.2-W.sup.3-W.sup.4 represents a carbon chain group connected to N and C═N, and thus forming a saturated, unsaturated, or partially unsaturated 5 or 6 membered nitrogen containing heterocycle, wherein W.sup.1, W.sup.2, W.sup.3 and W.sup.4 each individually represent CR.sup.vR.sup.w; R.sup.1, R.sup.2 may be hydrogen, halogen, etc.; R.sup.3 may be hydrogen, CN, C.sub.1-C.sub.6-alkyl, etc.; R.sup.4 may be of hydrogen, C.sub.1-C.sub.6-alkyl, C.sub.2-C.sub.6-alkenyl, C.sub.2-C.sub.6-alkinyl, C.sub.3-C.sub.8-cycloalkyl, Q-phenyl, Q′-O-phenyl, Q′-S-phenyl, where the phenyl ring is optionally substituted with one or more, e.g. 1, 2, 3, 4 or 5 identical or different substituents R.sup.10, and the moieties Q-Het.sup.#, Q′-O-Het.sup.# and Q′-S-Het.sup.# where Het# represents a heterocyclic radical and where Q and Q′ are C.sub.1-C.sub.6-alkandiyl, C.sub.2-C.sub.6-alkendiyl, or C.sub.2-C.sub.6-alkyndiyl, and where Q may also be a single bond; R.sup.3 and R.sup.4 together may also may also a bivalent radical, selected from the group consisting of C.sub.2-C.sub.5-alkandiyl, C.sub.2-C.sub.5-alkendiyl, Q″-C.sub.1-C.sub.4-alkandiyl and Q″-C.sub.2-C.sub.4-alkendiyl, where Q″ is O or S. The invention also relates to the use of the N-acylimino heterocyclic compounds, their stereoisomers, their tautomers and their salts, for combating invertebrate pests. Furthermore the invention relates also to methods of combating invertebrate pests, which comprises applying such compounds.

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

##STR00001##