Provided are modified cells and methods for their use in treating cancer. The cells are modified to express and secrete a Bi-specific T cell engager (BiTE) that includes a segment that specifically binds to human Folate Receptor alpha (FR) and a segment that that specifically binds to human CD3, such as CD3e. The modified cells can be T cells. Methods for producing the modified cells are also provided.

The present invention provides inducible chimeric cytokine receptors responsive to a ligand, e.g., a small molecule or protein, uses of such receptors for improving the functional activities of genetically modified immune cells, such as T cells, comprising the inducible chimeric cytokine receptors, and compositions comprising such cells.

The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

The present disclosure provides methods for expanding TIL populations from fine needle aspirates (FN As) or small biopsies which contain low numbers of TILs, using the methods disclosed herein including in a closed system that leads to improved phenotype and increased metabolic health of the TILs in a shorter time period.

A food product sterilizer includes a food product source and a regenerative heat exchanger configured to receive a flow of food product from the food product source. The heat exchanger includes an input channel configured to receive a flow of food product to be sterilized. The heat exchanger also includes an output channel fluidly coupled to the input channel. The output channel is adjacent the input channel. The output channel and the input channel are configured to transfer heat between the two channels. The heat exchanger further includes an integrated heating section of at least a portion of the input channel or the output channel. The heating section is configured to heat the flow of food product.