The present disclosure generally relates to the use of certain compounds, such as anthocyanins, saponins, or combinations thereof, at low concentrations to improve the aqueous solubility of flavonoid compounds. Thus, in certain aspects, the disclosure provides aqueous compositions including flavonoid compounds, such as naringenin or phloretin, and one or more compounds selected rom anthocyanin compounds, saponins, and combinations thereof. In related aspects, the disclosure provides methods and uses of certain compounds, such as anthocyanins, saponins, or combinations thereof, to enhance the aqueous solubility of flavonoid compounds. In related aspects, the disclosure provides methods to maintain the stability of a supersaturated aqueous solution of flavonoid compounds, for example, by increasing the kinetic stability of such supersaturated aqueous solutions. In some further embodiments of the foregoing aspects, the aqueous compositions are used to make flavored articles, such as beverage or dairy products, that contain concentration of surfactants, co-solvents, hydrotropes, or complexing agents below the typical taste-affecting thresholds in humans.

The present disclosure generally relates to the use of certain compounds, such as anthocyanins, saponins, or combinations thereof, at low concentrations to improve the aqueous solubility of flavonoid compounds. Thus, in certain aspects, the disclosure provides aqueous compositions including flavonoid compounds, such as naringenin or phloretin, and one or more compounds selected rom anthocyanin compounds, saponins, and combinations thereof. In related aspects, the disclosure provides methods and uses of certain compounds, such as anthocyanins, saponins, or combinations thereof, to enhance the aqueous solubility of flavonoid compounds. In related aspects, the disclosure provides methods to maintain the stability of a supersaturated aqueous solution of flavonoid compounds, for example, by increasing the kinetic stability of such supersaturated aqueous solutions. In some further embodiments of the foregoing aspects, the aqueous compositions are used to make flavored articles, such as beverage or dairy products, that contain concentration of surfactants, co-solvents, hydrotropes, or complexing agents below the typical taste-affecting thresholds in humans.

An extract of Citrus depressa, preferably a water and/or organic solvent extract of a fruit of leaf of Citrus depressa, a supercritical extract of a fruit of leaf of Citrus depressa, or a subcritical extract of a fruit of leaf of Citrus depressa, which comprise 0.3 mass % or more of a polymethoxyflavonoid more than in terms of solid matter, for example, an extract of Citrus depressa comprising 0.2 mass % or more of nobiletin and/or 0.1 mass % or more of tangeretin in terms of solid matter, or a polymethoxyflavonoid such as nobiletin or tangeretin is used as an active ingredient of an IGF-1 production-promoting agent.

An extract of Citrus depressa, preferably a water and/or organic solvent extract of a fruit of leaf of Citrus depressa, a supercritical extract of a fruit of leaf of Citrus depressa, or a subcritical extract of a fruit of leaf of Citrus depressa, which comprise 0.3 mass % or more of a polymethoxyflavonoid more than in terms of solid matter, for example, an extract of Citrus depressa comprising 0.2 mass % or more of nobiletin and/or 0.1 mass % or more of tangeretin in terms of solid matter, or a polymethoxyflavonoid such as nobiletin or tangeretin is used as an active ingredient of an IGF-1 production-promoting agent.

A method for treating inflammation, cancer, neurodegenerative diseases, diabetes, cardiovascular diseases, vascular diseases, cutaneous diseases, in a subject in need thereof. The method includes administering to a subject in need thereof an effective amount of a powdered food composition, obtained from lemon containing between 1% and 30% (w/w) of eriocitrin, in a dose of eriocitrin between 5 and 35 mg per day.

A method for treating inflammation, cancer, neurodegenerative diseases, diabetes, cardiovascular diseases, vascular diseases, cutaneous diseases, in a subject in need thereof. The method includes administering to a subject in need thereof an effective amount of a powdered food composition, obtained from lemon containing between 1% and 30% (w/w) of eriocitrin, in a dose of eriocitrin between 5 and 35 mg per day.

The present invention relates to the use of naringin, its aglycone form naringenin or mixtures thereof in the modulation of the expression of some specific gene receptors in ruminants and/or pigs which positively impact on feeding behaviour, intake patterns and animal behaviour.

The present invention relates to the use of naringin, its aglycone form naringenin or mixtures thereof in the modulation of the expression of some specific gene receptors in ruminants and/or pigs which positively impact on feeding behaviour, intake patterns and animal behaviour.

The present disclosure provides compositions containing: 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxychromen-4-one (“sinensetin”); 3,5,6,7,8,3′,4′-heptamethoxyflavone (“heptamethoxyflavone” or “HMF”); 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromen-4-one (“nobiletin”); 5,6,7,4′-tetramethoxyflavone (“tetra-O-methylscutellarein” or “TMS”); 3,5,6,7,3′,4′-hexamethoxyflavone (“hexamethoxyquercetogetin” or “HMQ”); 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one (“tangeretin”); or any combinations thereof. The disclosure also provides uses of such compositions as mouthfeel enhancers or bitterness maskers of flavored articles, such as beverages.

The present disclosure provides compositions containing: 2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxychromen-4-one (“sinensetin”); 3,5,6,7,8,3′,4′-heptamethoxyflavone (“heptamethoxyflavone” or “HMF”); 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-chromen-4-one (“nobiletin”); 5,6,7,4′-tetramethoxyflavone (“tetra-O-methylscutellarein” or “TMS”); 3,5,6,7,3′,4′-hexamethoxyflavone (“hexamethoxyquercetogetin” or “HMQ”); 5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one (“tangeretin”); or any combinations thereof. The disclosure also provides uses of such compositions as mouthfeel enhancers or bitterness maskers of flavored articles, such as beverages.