A method for sample encapsulation. A first sampling swab is provided that includes an absorbent portion and a fluid control portion that extends from the absorbent portion. The absorbent portion is proximate a proximal end of the first sampling swab. The fluid control portion is proximate a distal end of the first sampling swab. A sample is collected with the absorbent portion. At least a portion of the sample is liquid. An encapsulation material is provided that includes a first web and a second web. The first sampling swab is positioned between the first web and the second web. The first web is urged into contact with the second web proximate the absorbent portion. The urging of the first web into contact with the second web proximate the absorbent portion causes liquid to move from the absorbent portion towards the fluid control portion. The urging of the first web into contact with the second web proximate the absorbent portion is discontinued which causes the liquid to be drawn into the absorbent portion. The first web is urged into contact with the second web proximate the distal end of the first sampling swab to encapsulate the liquid in the encapsulation material.

Provided is a cell isolation instrument capable of smoothly performing a plurality of steps associated with isolation of cells, including gripping of a biological tissue, transferring of the biological tissue, and isolating of the biological tissue. A container has an opening. A sealing member seals the opening. A pair of pinching parts is connected to the sealing member, and the pair of pinching parts opens or closes by being pressed.

A tissue holder cap for covering a tissue holder includes a cover having a perimeter, the cover having an outer surface and an inner surface opposite from the outer surface. The cover includes a central portion having an opening configured for receiving a central post of the tissue holder, a first latch extending from the perimeter of the cover, and a second latch extending from the perimeter of the cover, circumferentially spaced apart from the first latch. The cover also includes a first protrusion configured to engage the post of the tissue holder. When the first protrusion engages with the post, each of the first latch and the second latch automatically aligns with one or more of a plurality of tabs on located on a circumferential sidewall of the tissue holder to thereby securely fasten the tissue holder cap onto the tissue holder.

A container (1) for biologic samples has a lower receptacle (2), an upper receptacle (3) for a toxic liquid (LF) or considered as such, having a radial ring (63), and a connecting sleeve (4) with a circumferential rim (54) and a transversal septum (40), provided with a central vent opening (55) and with a plurality of transfer openings (51) for the transfer of toxic liquid (LF). The toxic liquid (LF) is sealed between the upper receptacle (3) and the transversal septum (40) before unscrewing the upper receptacle until its radial ring (63) touches the circumferential rim (54). When unscrewing the upper receptacle (3), the toxic liquid (LF) reaches and passes through the plurality of transfer openings (51), and air contained in the lower receptacle (2) flows into the upper receptacle (3) through the central vent opening (55), without any exit of gases and liquids from the container (1).

The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

A core biopsy system includes a core biopsy needle device and biopsy sample collection device, wherein the core biopsy needle device is positionable within and movable with respect to the biopsy sample collection device. Systems and methods for obtaining multiple biopsy samples with a single insertion of a needle of the biopsy needle device include obtaining sequential samples and storage in a multi-cell cartridge. Additional features and methods of the invention include obtaining two sample portions from each sample acquisition, wherein each of the two sample portions can be separately preserved and analyzed.

A method of obtaining and analyzing at least one tissue sample includes forming, in a tissue container, first tracking data associated with the at least one tissue sample. Second tracking data is formed, in a transport container. The second tracking data is associated with the at least one tissue sample. The at least one tissue sample is placed in the tissue container. The first and second tracking data from the tissue container and the transport container are scanned with an electronic scanning system to ensure that the first and second tracking data are both associated with the removed tissue sample.

An apparatus for individually storing multiple tissue samples separately from each other includes a base, a lid, a lock, and one or more vents. The base defines a plurality of reservoirs and a plurality of identification areas. A portion of the base defines an opening corresponding to each reservoir. The lid is configured to secure the multiple tissue samples within a corresponding reservoir by enclosing each corresponding opening in the closed configuration. The lock is configured to selectively lock the lid against the base in the closed configuration. The one or more vents are configured to enable entry of fluid into the reservoirs when the lid is in the closed configuration. The one or more vents are further configured to prevent exit of tissue samples from the reservoirs when the lid is in the closed configuration.