A medical device for left atrial appendage closure includes a support frame with a proximal collar and a distal collar, where the support frame is actuatable from a first constrained configuration to a second radially expanded configuration. A membrane is disposed on at least a portion of the support frame, and an engagement element is coupled to the distal end region of the support frame. The engagement element extends distally from the support frame and is configured to engage an inner surface of the left atrial appendage and prevent the support frame from sliding along the inner surface of the left atrial appendage during implantation.

An apparatus includes an occlusion device operable to fit securely in an anatomical passageway within a head of a human. The occlusion device is configured to move unitarily with the head when the occlusion device is installed in the anatomical passageway. The occlusion device is further configured to prevent passage of fluid through the anatomical passageway when the occlusion device is installed in the anatomical passageway. A position sensor is fixedly integrated into the occlusion device. The position sensor generates signals indicating a position of the occlusion device in three-dimensional space, thereby indicating the position of the head in three-dimensional space. A connector communicatively coupled to the position sensor is operable to receive and transmit the signals generated by the position sensor.

An embodiment includes a system comprising: a catheter; an optic fiber having a long axis and a short axis that is orthogonal to the long axis; first and second radiopaque elements coupled to the optic fiber; a first wire coupled to the optic fiber and extending from the first radiopaque element to the second radiopaque element; a fluid; wherein (a)(i) the first wire wraps at least partially around an exterior surface of the optic fiber; (a)(ii) an outer diameter of the first wire and an outer diameter of the optic fiber are collectively less than an inner diameter of the catheter, and (a)(iii) the first wire is configured to center the optic fiber within the catheter within a plane orthogonal to the long axis.

Medical systems, devices and methods are provided for engaging tissue, e.g. for clipping tissue, closing a perforation or performing hemostasis. Generally, the medical system including a housing, first and second jaws rotatable relative to the housing, a driver, and an elongate drive wire. The elongate drive wire may be disconnected from the driver, first and second jaws, and the housing, which are left in vivo engaged with the tissue.

Degree of occlusion is monitored for an occlusive device configured to occlude passage of fluid between two compartments in a lumenal space of a body of a patient. In some embodiments, changes in an electrical signal measured from the body of the patient are induced by perturbing the fluid; for example, by “tagging” a portion of fluid with a perturbation of temperature and/or composition. The degree of occlusion is estimated based on the measured changes. The electrical signal changes may be indicative of fluid movements redistributing the perturbed fluid among the two compartments; for example, by diffusion, mixing, and/or jetting of fluid.

The disclosure relates to a medical kit for the treatment of vascular malformations, in particular aneurysms and/or fistulas, having a permanently implantable covering device, in particular a stent, for covering the vascular malformation, the covering device having a tubular, self-expandable lattice structure and a covering made of an electrospun fabric, the covering being connected to the lattice structure and overlapping the lattice structure at least in part such that, when implanted, the covering is placed over the vascular malformation; and an embolisation means, which can be applied by a feed means in the implanted state for treatment of the vascular malformation, the covering forming a porous membrane which can be penetrated by the feed means for application of the embolisation means and which is designed to lie against the outer periphery of the feed means in the penetrated state.

A conformational state of a medical device operated within a body lumen is determined by measuring, using the medical device as an electrode, an electrical parameter which varies in a correspondence with a conformational state (e.g., deployment state) of the portion of the medical device used as the electrode. The conformational state of the medical device is determined, based on the electrical parameter; and an image is presented indicating the determined conformational state. In some embodiments, the electrical parameter is a self-impedance of the portion of the medical device used as the electrode. In some embodiments, current positioning of the medical device is used as part of calibrating a parametric relationship between the electrical parameter and conformational states of the medical device.

Electrical field-guided positioning of a second device within a body cavity, using electrical field mapping information generated from electrical field measurements by electrodes of a first device. The first device, in some embodiments, is a catheter electrode probe, and the second device is an internally implantable and/or operated medical device. An exposed, electrically conductive portion of the second device is optionally configured to be used as an electrical field measuring electrode. A rule is applied to measurements made by this electrode to estimate its position within a body cavity. The rule is generated, in some embodiments, using measurements made by the first device. In some embodiments, electrical measurements are used to guide implantation verification. In some embodiments, electrical measurements are used to guide navigation at and through a septal wall between body cavities.

An implant (1) for the treatment of arteriovenous deformities, in particular aneurysms (2). In an expanded state the implant has a basic body (6) comprising of a proximal and a distal segment (7, 8), with the proximal and the distal segment (7, 8) being of dome-shaped configuration, with the convex side of the dome of the proximal segment (7) facing in the proximal direction and the convex side of the dome of the distal segment (8) facing in the distal direction, and wherein the proximal and the distal segment (7, 8) are connected to each other via a plurality of connecting struts (9). Alternatively, the implant (1) may have the shape of a closed tulip blossom. The inventive implant (1) is able to adapt well to the shape of the respective aneurysm (2).

A biodegradable flow diverting device (BFDD) that will regulate blood flow into an aneurysmal sac, act as a scaffold for endothelization at the neck of an aneurysm, and degrade after successful dissolution of aneurysm and remodeling of blood vessel. This BFDD and associated fabrication method have the following features: (1) This is a non-braided FDD. The pore shapes, sizes, architectures (especially at the inlet and outlet of the pores), pore densities and porosities can be controlled for the optimum performance depending on the blood vessel and aneurysmal morphologies from patient MRI images, (2) BFDD is developed on a rotary arm with programmable variable speed and diameter in conjunction with a micromotion stage (3) Fabrication system can take any material including blended/composite biomaterials by adjusting temperature of the electro-melt extruder/needle and (4) Fabrication system is compatible with CAM (computer aided manufacturing) software and able to operate based on the adapted G-code.