Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and/or skin repositioning and/or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

A micropigmentation device and related method of use may be used for micropigmentation and other similar procedures. The micropigmentation device may include two needle tips, which may optionally each be part of a separate needle or may be tips on a single component, such as a single needle. In other embodiments, the device may include pairings of needle tips, such as two components with each having a plurality of needle tips or a plurality of needles grouped into two groupings of needle tips. The device may be used to simulate natural human hair follicles as they grow in pairs.

The present invention provides for microneedle arrays and related systems and methods. Particularly, microneedle arrays that are configured to deliver active agents, including nucleic acids and vaccines, are provided. Additional related methods of vaccinating and minimizing the amount of vaccine necessary for effective inoculation are also provided.

Exemplary methods and systems can be provided for resurfacing of skin that include formation of a plurality of small holes, e.g., having widths greater than about 0.2 mm and less than about 0.7 mm or 0.5 mm, using a mechanical apparatus. Compressive and/or tensile forces can then be applied to the treated region of skin as the damage heals to facilitate hole closure, and provide enhanced and/or directional shrinkage of the treated skin area.

According to some embodiments, a method of treating a skin surface of a subject comprises heating a skin surface, abrading native skin tissue of a subject using a microdermabrasion device, wherein using the microdermabrasion device comprises moving the microdermabrasion device relative to the skin surface while simultaneously delivering at least one treatment fluid to the skin surface being treated and cooling the abraded skin surface.

A hair follicle implant device includes a needle holding assembly configured to hold a plurality of needles and a needle guide slidably coupled thereto and configured to provide a skin stop surface while guiding the plurality needles. A plurality of pistons is configured to slide within a respective one of the plurality of needles. A piston base is slidably coupled to the needle holding assembly and is configured to hold the pistons to slide within the plurality of needles when actuated during implantation. A spring, carried between the needle holding assembly and the piston base, is configured to bias the piston base in a retracted position, wherein the spring is offset from a central axis of the piston base. The needle holder holds the plurality of needles in the staggered arrangement offset from the central axis of the piston base.

A needling device includes a plurality of needles forming a needle array, and a motor assembly for driving the needle array, where each of the plurality of needles includes a needle tip at one end, and tapers at a taper angle and along a taper length to a maximum needle diameter at the other end, and in use, a skin reference surface of the needling device is in contact with a subject's skin.

Disclosed herein are devices (e.g., needles (e.g., hollow needles), hollow staples, articles, apparatuses, and systems), kits, and methods for treating skin and skin conditions, for example, by promoting skin tightening, such as by reducing skin laxity and reducing tissue area or volume.

A transfer device for a living organism for placing an object in a living organism comprises a plurality of movable units. Each movable unit comprises one or more needles extending in a first direction. Each needle has a cylindrical shape capable of storing the object therein. Each movable unit is movable in the first direction.

A skin treatment device includes a control unit and a hand tool. The hand tool includes a body, a wiper head, and a needle roller head. The wiper head includes a rotatable wiper structure including one or more wiper blades. The needle roller head includes needle roller structure. The skin treatment device provides a multi-step process including desincrustation, skin transdermal delivery of topical agents, serums, and the like, microdermabrasion, and fractional micro-channeling application.