Delivery devices, systems, and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. Thus, the system enables subpial delivery, which leads to a near complete spinal parenchymal AAV9-mediated gene expression or ASO distribution in both white and grey matter.

In one embodiment, a method of implanting a stimulation lead to stimulate a dorsal root ganglion (DRG) of a patient, comprises: placing a distal portion of the stimulation lead within an implant tool; accessing the epidural space of the patient with the distal end of the implant tool; contacting a surface of a pedicle of the patient with a distal tip of the implant tool above a foramen leading to a target DRG; after contacting the surface of the pedicle with the distal tip, advancing the stimulation lead from a side port of the implant tool, wherein the side port is located proximal to the distal tip of the implant tool; advancing the stimulation lead through the foramen to position one or more electrodes of the stimulation lead adjacent to the target DRG; and providing electrical stimulation to the target DRG to stimulate the target DRG using one or more electrodes of the stimulation lead.

A positioning device includes a base extending in a horizontal plane, a support post extending along a vertical axis, a detachable headrest subassembly attached to an end of the support post opposite the base, an arm rest subassembly attached to the support post between the headrest subassembly and the base, a thoracic support subassembly attached to the support post between the armrest subassembly and the base, A thoracic support cushion is attached to the support post by a bar. The attachment is reconfigurable to vary an orientation and location of the cushion with respect to the vertical axis, a footrest subassembly attached to the support post between the thoracic support subassembly and the base, and a digital device holder attached to the positioned device by a flexible arm, the flexible arm configured to support a digital device in view of the patient during use of the positioning device.

In some embodiments, disclosed herein are systems and methods of treating a patient that can include the steps of accessing the sphenopalatine fossa, and cannulating the inferior orbital fissure from the sphenopalatine fossa to access the retro-orbital space. The sphenopalatine fossa can be accessed via various routes, including percutaneously. Accessing the sphenopalatine fossa can include the step of inserting a needle-catheter system into the sphenopalatine fossa. Integrated needle-catheter systems as described herein can also be configured to access the trigeminal ganglion, epidural space, intrathecal space, and other desired anatomical locations.

A medical puncture device system includes a puncture device, a sensor, and an indicator system. The puncture device is configured to create a puncture through patient tissue and into an internal patient cavity to enable a medical tool to be inserted through the puncture into the cavity. The sensor is configured to generate a signal indicative of motion of the puncture device through the tissue into the cavity. The indicator system is operable by a controller to produce human-perceptible feedback in response to the signal generated by the sensor.

In a handle unit for interventional procedure, a master device for interventional procedure, and a remote control interventional procedure system, the handle unit is gripped by an operator. The handle unit includes a gripper, a mode selection module and a linear motion module. The gripper is gripped by the operator. The mode selection module is equipped to the gripper, and selects one of motion modes including a linear motion mode, a rotational motion mode and a plane motion mode. The needle linearly moves with one degree of freedom in the linear motion mode. The needle rotationally moves with two degrees of freedom in the rotational motion mode. The needle moves in a plane with two degrees of freedom in the plane motion mode. The linear motion module performs the linear motion of the needle based on the selection of the mode selection module, and is equipped to the gripper.

The present application relates to a cannula, comprising a cannula body with a cannula tube and a body part attached to the proximal end of the cannula tube, a control clip having a mounting body with at least one control element, said control clip being attachable laterally on the body part to form a first configuration. In addition, the present applications relates to a cannula body, a contact clip and a control clip of a cannula.

A precision forward-looking image-guided diagnostic and therapeutic surgical probe and needle insert for microsurgery in support of imagery, neurology, neurosurgical procedures, and ophthalmic surgical applications comprising an introducer needle (stylet), a fiber carrier, a therapeutic conduit, and a spirographic method for scanning a target and associated algorithms to create and render a reconstructed image for display to a physician in real-time or near real-time. The probe implements Optical Coherence Tomography (OCT) to provide high-resolution extended imagery of an intended therapeutic or target tissue. A separate therapeutic conduit provides surgical access for therapeutic devices such as a cutting or ablation laser, an RF electrode for locally heating tissue, a lumen for local injection of neurolytics/paralytics, placement of electrodes for neuromodulation, and deployment of a micro-endoscopic imaging tool. A third working channel supports the delivery of neurolytic and other fluids.

A device for positioning a needle tip to a desired location by signaling pressure change is provided. The device includes a barrel, a piston, a biasing element, and a plunger. The barrel defines a reservoir, and it includes a distal end connectable to a puncturing apparatus. The plunger is slidably engaged with the piston, and both are movable within the reservoir. The biasing element connects the plunger and the piston, and its change in length corresponds to the relative position of the plunger and piston. In operation, the piston is at a first position relative to the plunger when the biasing element is at a first length. The piston later moves to a second relative position in response to the biasing element's change of the length resulting from a pressure change inside the reservoir when the puncturing apparatus reaches a location of a mass. The position's change of the piston is visually detectable.

The present disclosure relates to an auxiliary device and auxiliary method for epidural anesthesia needle placement, the auxiliary device comprising: a needle placement unit (1), a motion guide unit (2) for driving the needle placement unit into movement, and a control unit (3) for supporting and controlling the motion guide unit (2), the needle placement unit (1) being electrically connected to the control unit (3); the needle placement unit (1) comprises: a first support (11) connected to the motion guide unit (2), a second support (12) slidably connected with the first support (11), a needle placement assembly (13) slidably connected with the second support (12), and a first drive (14) arranged on the first support (11) for driving the second support (12) into motion. The scheme of the present disclosure may perform a real-time multidimensional monitoring to the puncture process, achieving autonomous, precise, safe needle placement and puncture operations.