A tissue sample processing system and associated methods is disclosed and described. The tissue sample processing system (100) can include a microfluidic separating system (110). The microfluidic separating system (110) can include a fluid channel to receive a carrier fluid (104) and a tissue sample (102), and a plurality of outlets. Flow of the carrier fluid (104) and the tissue sample (102) in the fluid channel can facilitate segregation of materials in the tissue sample (102) based on size into a plurality of size fractions, such that each one of the plurality of outlets receives a different size fraction of the materials in the tissue sample. In addition, the sample processing system (100) can comprise a cryopreservation system (120) associated with at least one of the plurality of outlets to freeze the material in the tissue sample (102) associated with the at least one of the plurality of outlets.

A tissue sample processing system and associated methods is disclosed and described. The tissue sample processing system (100) can include a microfluidic separating system (110). The microfluidic separating system (110) can include a fluid channel to receive a carrier fluid (104) and a tissue sample (102), and a plurality of outlets. Flow of the carrier fluid (104) and the tissue sample (102) in the fluid channel can facilitate segregation of materials in the tissue sample (102) based on size into a plurality of size fractions, such that each one of the plurality of outlets receives a different size fraction of the materials in the tissue sample. In addition, the sample processing system (100) can comprise a cryopreservation system (120) associated with at least one of the plurality of outlets to freeze the material in the tissue sample (102) associated with the at least one of the plurality of outlets.

An oocytes or ovum retrieval device is disclosed. The device may include a retrieval catheter dimensioned for transvaginal insertion into a cervical canal and for advancing distally into a fallopian tube and the ampulla of a female mammal. The retrieval catheter may include one or more fluid delivery lumens having a fluid delivery port for delivering a flushing fluid into said fallopian tube, an at least one aspiration opening in fluid connection with an internal aspiration lumen of said retrieval catheter, wherein the size of the at least one aspiration opening is determined based on a size of oocytes or ovum.

An oocytes or ovum retrieval device is disclosed. The device may include a retrieval catheter dimensioned for transvaginal insertion into a cervical canal and for advancing distally into a fallopian tube and the ampulla of a female mammal. The retrieval catheter may include one or more fluid delivery lumens having a fluid delivery port for delivering a flushing fluid into said fallopian tube, an at least one aspiration opening in fluid connection with an internal aspiration lumen of said retrieval catheter, wherein the size of the at least one aspiration opening is determined based on a size of oocytes or ovum.

A fallopian tube access system includes an outer tube assembly including an outer tube and a sleeve extending distally from the outer tube, and an inner tube assembly including an inner tube and an expander extending distally from the inner tube. The inner tube assembly is positioned within the outer tube assembly such that the expander is located within the sleeve in a compressed state. The outer tube assembly is movable relative to the inner tube assembly to expose the expander and transition the expander from the compressed state to an expanded state.

Methods and systems are for improvements to in-vitro fertilization using morpho-kinetic signatures. These improvements are achieved by analyzing a series of images of a developing embryo (e.g., time-lapse images) as opposed to a single static image. For example, due to the difficulty in identifying clear distinctions between morphological states based on static images, as well as the unpredictability of morpho-kinetic development of an embryo, the system analyzes the development of an embryo as a whole over a given time frame (e.g., fertilization to blastulation), which provides a better prediction of the viability of a given embryo. The analysis may take the form of a morpho-kinetic signature, which itself may be used to determine an optimal time to transfer and/or implant an embryo into a patient.

Devices, systems, and methods for delivering fluid are provided. Devices include a housing configured for intravaginal deployment and retention, at least one reservoir configured to contain a fluid, and a fluid dispensing mechanism configured to dispense the fluid past the cervix and to the uterus of the subject. Methods include intravaginally deploying and retaining a device in the subject, and dispensing the fluid from the device such that the fluid is driven past the cervix to the uterus of the subject.

The present invention relates to improved assisted reproductive technology for women predicted to have a high ovarian response to controlled ovarian stimulation that comprise targeting a threshold serum hCG level by the final day of stimulation.

The present invention relates to improved assisted reproductive technology for women predicted to have a high ovarian response to controlled ovarian stimulation that comprise targeting a threshold serum hCG level by the final day of stimulation.

A Catheter for the transfer of human embryos including an outer catheter characterized by an integrated element of transverse folds in the shape of an “accordion” at a specific distance from its tip. When being compact, the element of transverse folds is 1 cm long while the distance of its center from the tip of the catheter is 5.5 cm but can vary +/−1 cm. The element of transverse folds has the ability to bend, expand, compress and generally be configured in the desired shape and angle by the operating clinician in order to facilitate its passage through the cervical channel. The shape and angle are capable of being re-configured by the operating clinician if deemed necessary. The element of transverse folds is also capable of automatically adjusting in shape and angle during its passage through the cervix, following the anatomy of the cervical channel.