Devices, systems, and methods for localized delivery of a chemotherapy, hormonal therapy, or targeted drug/biologic therapy to a target tissue area of an internal body organ of a patient. Computer systems may be used for planning and navigation in super selective drug delivery via a tracheobronchial airway. A catheter may be used to form a sealed treatment chamber in a natural lumen extending through the target tissue area. Air is purged from the chamber, which is then filled with a liquid drug solution for an adequate treatment session time, solution volume and drug concentration to saturate the target tissue area, thereby providing the treatment. The liquid drug solution may be circulated or recirculated through the chamber or maintained stationary therewithin to saturate the target tissue area. The chamber is evacuated at the end of the treatment session.

A method of displaying an operational parameter of a surgical system is disclosed. The method includes receiving, by a cloud computing system of the surgical system, first usage data, from a first subset of surgical hubs of the surgical system; receiving, by the cloud computing system, second usage data, from a second subset of surgical hubs of the surgical system; analyzing, by the cloud computing system, the first and the second usage data to correlate the first and the second usage data with surgical outcome data; determining, by the cloud computing system, based on the correlation, a recommended medical resource usage configuration; and displaying, on respective displays on the first and the second subset of surgical hubs, indications of the recommended medical resource usage configuration.

Degree of occlusion is monitored for an occlusive device configured to occlude passage of fluid between two compartments in a lumenal space of a body of a patient. In some embodiments, changes in an electrical signal measured from the body of the patient are induced by perturbing the fluid; for example, by “tagging” a portion of fluid with a perturbation of temperature and/or composition. The degree of occlusion is estimated based on the measured changes. The electrical signal changes may be indicative of fluid movements redistributing the perturbed fluid among the two compartments; for example, by diffusion, mixing, and/or jetting of fluid.

A conformational state of a medical device operated within a body lumen is determined by measuring, using the medical device as an electrode, an electrical parameter which varies in a correspondence with a conformational state (e.g., deployment state) of the portion of the medical device used as the electrode. The conformational state of the medical device is determined, based on the electrical parameter; and an image is presented indicating the determined conformational state. In some embodiments, the electrical parameter is a self-impedance of the portion of the medical device used as the electrode. In some embodiments, current positioning of the medical device is used as part of calibrating a parametric relationship between the electrical parameter and conformational states of the medical device.

Electrical field-guided positioning of a second device within a body cavity, using electrical field mapping information generated from electrical field measurements by electrodes of a first device. The first device, in some embodiments, is a catheter electrode probe, and the second device is an internally implantable and/or operated medical device. An exposed, electrically conductive portion of the second device is optionally configured to be used as an electrical field measuring electrode. A rule is applied to measurements made by this electrode to estimate its position within a body cavity. The rule is generated, in some embodiments, using measurements made by the first device. In some embodiments, electrical measurements are used to guide implantation verification. In some embodiments, electrical measurements are used to guide navigation at and through a septal wall between body cavities.

Aspects of embodiments pertain to a perineal protection device for reducing the risk or preventing perineal tear during birth. The device may comprise a reinforcement shield that is releasably connectable to a female perineum of a subject, the reinforcement shield having a surface geometry substantially corresponding to an underlying perineal muscle structure and being configured to reduce deformation of the perineum during childbirth. Optionally, the perineal protection device further comprises a fastener arrangement for releasably securing the reinforcement shield to the female perineum. The fastener arrangement may comprise a support pad that is adhesively engageable with the subject and/or straps for strapping the reinforcement shield to the subject.

Various systems and methods for controlling the activation of energy surgical instruments are disclosed. An advance energy surgical instrument, such an electrosurgical instrument or an ultrasonic surgical instrument, can include one or more sensor assemblies for detecting the state or position of the end effector, arm, or other components of the surgical instrument. A control circuit can be configured to control the activation of the surgical instrument according to the state or position of the components of the surgical instrument.

Ablation catheters and systems include coaxial catheter shafts with an inner lumen for delivering an ablative agent and an outer lumen for circulation of a cooling element about the catheter. Induction heating is used to heat a chamber and vaporize a fluid within by wrapping a coil about a ferromagnetic chamber and providing an alternating current to the coil. A magnetic field is created in the area surrounding the chamber which induces electric current flow in the chamber, heating the chamber and vaporizing the fluid inside. Positioning elements help maintain the device in the proper position with respect to the target tissue and also prevent the passage of ablative agent to normal tissues.

A catheter system for treating a treatment site within or adjacent to a vessel wall or a heart valve includes an energy source, a balloon, an energy guide, and an electrical analyzer assembly. The energy source generates energy. The balloon is positionable substantially adjacent to the treatment site. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The energy guide is configured to receive energy from the energy source and guide the energy into the balloon interior. The electrical analyzer assembly is configured to monitor a balloon condition during use of the catheter system. The electrical analyzer assembly can include a first electrode, a second electrode, and an impedance detector that is electrically coupled to the first electrode and the second electrode. The impedance detector is configured to detect impedance between the first electrode and the second electrode.

A method of ultrasonic sealing includes activating an ultrasonic blade temperature sensing, measuring a first resonant frequency of an ultrasonic electromechanical system that includes a transducer coupled to the blade via a waveguide, making a first comparison between the measured first resonant frequency and a first predetermined resonant frequency, and adjusting a power level applied to the transducer based on the first comparison. The first predetermined frequency may correspond to an optimal tissue coagulation temperature. The method may further include measuring a second resonant frequency of the system, making a second comparison between the measured second frequency and a second predetermined frequency, and adjusting the power level based on the second comparison. The second predetermined frequency may correspond a melting point temperature of a clamp arm pad. An ultrasonic instrument and a generator may implement the method.