A system for removing an occlusive clot from a blood vessel comprises a catheter and an apparatus for generating a pulsatile vacuum force to pulse the pressure gradient at a distal end of the catheter. The pulse generator may be integral with or separate from the vacuum pump. The pulse generator may be applied to a flexible tubing between the vacuum pump and the proximal end of the catheter.

A method of non-thermally ablating undesirable tissue in the body by application of pulsed, bipolar, instant charge reversal electrical fields of sufficient energy to cause complete and immediate cell membrane rupture and destruction. Energy is delivered through radio frequency pulses of particular frequencies, wave characteristics, pulse widths and pulse numbers, such that enhanced physical stresses are placed on the cell membrane to cause its immediate and complete destruction thereby spilling the entire cell content and membrane constituents into, the extracellular space without denaturing proteins so as to enable an immunological response to destroy and remove the target tissue and similarly marked tissue elsewhere in the subject.

Damaged, diseased, abnormal, obstructive, cancerous or undesired neural tissue treated by delivering specialized pulsed electric field (PEF) energy to target tissue areas. In some instances, the target tissue includes a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue. Most brain and spinal cord tumors develop from glial cells. These tumors are sometimes referred to as a group called gliomas. They arise from the supporting cells of the brain, called the glia. These cells are subdivided into astrocytes, ependymal cells and oligodendroglial cells (or oligos). One difficulty in the treatment of gliomas is that they are behind the blood-brain barrier (BBB) and blood-tumor barrier (BTB) which leads to poor delivery of anti-cancer drugs or immune agents to the tumor-infiltrated brain. Devices, systems and methods are provided that treat the tumor directly, such as by ablation, and optionally transiently disrupt the BBB coupled with adjuvant antibody, biologic, or other pharmaceutical interventions.

A catheter system (100) includes an inflatable balloon (104), an optical fiber (122), and a laser (124). The optical fiber (122) has a distal end positioned within the inflatable balloon (104). The optical fiber (122) receives an energy pulse (431) to emit light energy in a direction away from the optical fiber (122) to generate a plasma pulse (134) within the inflatable balloon (104). The laser (124) includes a seed source (126) that emits a seed pulse (342) and an amplifier (128) that increases energy of the seed pulse (342) so that the laser (124) generates the energy pulse (431) that is received by the optical fiber (122), the energy pulse (431) having a waveform with a duration T, a minimum power PO, a peak power PP, and a time from PO to PP equal to TP.

An aspiration system includes a pump and a control system in communication with the pump. The control system includes a microcontroller, an antenna configured to receive a signal, and a pump control board in communication with the microcontroller. The antenna is in communication with the microcontroller. Upon receiving the signal, the pump control board operates the pump to create negative pressure according to the signal.

Retrieval of material from vessel lumens can be improved by electrically enhancing attachment of the material to the thrombectomy system. The system can include a catheter having a distal portion configured to be positioned adjacent to a thrombus in a blood vessel, an electrode disposed at the distal portion of the catheter, and an interventional element configured to be delivered through a lumen of the catheter. The electrode and the interventional element are each configured to be electrically coupled to an extracorporeal power supply.

A catheter system includes an inflatable balloon, an optical fiber and a laser. The optical fiber has a distal end positioned within the inflatable balloon. The optical fiber receives an energy pulse to emit light energy in a direction away from the optical fiber to generate a plasma pulse within the inflatable balloon. The laser includes a seed source that emits a seed pulse, and an amplifier that increases energy of the seed pulse. The energy pulse can have a somewhat square or triangular waveform with a duration T, a minimum power P.sub.0, a peak power P.sub.P, and a time from P.sub.0 to P.sub.P equal to T.sub.P, wherein T.sub.P is not greater than 40% of T. T can be within the range of greater than 50 ns and less than 3 μs. T.sub.P can be within the range of greater than 2.5 ns and less than 1 μs. P.sub.P can be within the range of greater than 50 kW and less than 1000 kW. A ratio in kW to ns of P.sub.P to T.sub.P can be greater than 1:5. The seed pulse can at least partially increase in amplitude over time.

Provided is a light-hydrogen therapy including a lighting module, a lighting apparatus and a lighting method. The process of operation is to continuously or discontinuously emit near infrared rays or visible red light to the lower back part of a human head and next to the human neck, while in combination with drinking hydrogen water with dissolved hydrogen of 0.1 ppm to 6 ppm in a container or inhaling a hydrogen gas with 0.1% to 3.8% hydrogen in a container, to improve the body functions of PD patients.

A non-invasive electrodynamic radiative electroporation system and method for safe in vivo delivery of specific radiant energy to physiologically inaccessible sites for selective destruction of biomolecular function of virions, particularly Covid-19 and its variants. The system and method applies a computer or like controller to generate, modulate, direct and deliver applied external electric fields from plural antennas to target tissues in the full respiratory tract, including lung microstructures, cardiovascular tissues and neuron networks. Electric fields exceeding a critical threshold-value interact with the virus lipid bilayer membranes, intra-membrane organelles, mRNA, and biomolecular scaffold assemblies, to destroy virion function through irreversible electroporation and electropermeabilization. Polarized electric fields are generated to provide force vectors in optimal dynamic angular distribution to the virion membrane surface and modulated within time-scales short compared to thermal transport characteristic times to effect the electroporation as an adiabatic process that preempts Joule heating of normal tissues.

A surgical device drive system comprising a gear coupled to a drive train is disclosed. The gear is configured to transmit a proximal retraction motion to a drive member. The surgical device drive system further comprises a control system coupled to the gear, and a manual input device comprising an input component and a ratchet mechanism. The input component is selectively coupled to the gear by the ratchet mechanism. The drive train is operable in a distal advancement direction and in a proximal retraction direction. In a first state, the control system is configured to drive the gear and the drive train in the distal advancement direction and the proximal retraction direction. In a second state, the manual input device is configured to drive the gear and the drive train in the proximal retraction direction, but not the distal advancement direction, using the ratchet mechanism.