Systems and methods for electroporation are provided. An electroporation system includes a catheter including a plurality of electrodes, and a pulse generator coupled to the catheter, the pulse generator configured to generate a waveform to be delivered using at least one of the plurality of electrodes. The waveform includes a first pulse having a first polarity, a first pulse amplitude, and a first pulse width, and a second pulse having a second polarity, a second pulse amplitude, and a second pulse width, wherein the first and second pulses are separated by an interpulse delay, and wherein at least one of i) the first pulse amplitude is different than the second pulse amplitude and ii) the first pulse width is different than the second pulse width.

A method of operating a robotically controlled surgical instrument that includes an end effector, a driving assembly, and a lockout, the method includes inhibiting actuation of the driving assembly when the lockout is in a locked configuration in response to an unspent staple cartridge being absent from a first jaw of the end effector. The method also includes inserting the unspent staple cartridge into the first jaw of the end effector to switch the lockout to an unlocked configuration. The method also includes actuating the driving assembly to pivot the first jaw, which includes the staple cartridge, toward a second jaw of the end effector to at least one of staple or cut tissue with the end effector when the lockout is in the unlocked configuration.

Disclosed is a surgical instrument for cataract eye surgery. The instrument generally includes a handpiece that delivers sub-ultrasonic and ultrasonic vibrations in either a continuous emulsification mode or with on-off pulses that dynamically drive a hollow needle in either a pulsed fragmentation mode or a pulsed emulsification mode. The pulsed fragmentation mode is efficient at cutting lens tissue and the pulsed emulsification mode is efficient in emulsifying the cut lens tissue. The pulsed modes manage heat buildup from becoming excessive in the eye during the cataract surgery. While in the pulsed fragmentation mode, the hollow needle is never given the chance to vibrate at an established resonant frequency of the handpiece due to the short on-off period. In contrast, the pulsed emulsification mode has a long enough on-off period to permit an ultrasonic resonant frequency in the handpiece to develop, which drives the hollow needle at a higher energy than the pulsed fragmentation mode.

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.”

Embodiments relate to circuitry to provide amplitude modulated waveforms in electrosurgical devices. The circuitry can be included in an electrosurgical generator device to provide the amplitude modulated waveforms to an electrosurgical probe coupled with the electrosurgical generator device.

Various embodiments provide an electrosurgical apparatus for treating biological tissue with microwave energy. The apparatus comprises: a microwave energy signal generator for generating a microwave energy waveform; an electrosurgical instrument arranged to deliver the microwave energy waveform from a distal end thereof for tissue treatment; and a controller in communication with the microwave energy signal generator. The microwave energy signal generator is configured to deliver the microwave energy waveform as one microwave energy signal pulse. The controller is configured to control the profile of the one microwave energy signal pulse to cause ablation or coagulation of the biological tissue and to substantially prevent the one pulse from causing heat to build-up in the electrosurgical instrument.

A handpiece-type high-frequency vibration cutting device includes a housing (10); a vibration device (21); a holding member (11); a tool (12); and a controller (20) to control the operations of the vibration device (21). The controller (20) controls the vibration of the tool (12) due to the vibration device (21) such that the vibration is burst oscillation in which vibration and stop of vibration are repeated. The controller (20) also controls the entire burst frequency f1 of the tool (12) to be included in the range of 1 to 8 [Hz], one cycle of the burst frequency f1 including a burst period with the holding member (11) vibrating and a stop period with the tool (12) not vibrating. The controller (20) also controls the vibration frequency f2 of the tool (12) during the burst period such that the vibration frequency f2 is in the range of 20 to 60 [kHz].

A method of controlling an eye surgical laser is disclosed for the separation of a volume body with predefined posterior and anterior interfaces from a human/animal cornea. The method including controlling the laser with a control device, the laser being configured to emit pulsed laser pulses in a predefined pattern into the cornea. The posterior and anterior interfaces of the volume body are defined by the predefined pattern and are generated by an interaction of the individual laser pulses with the cornea through photodisruption. The control device controls the laser beam such that both interfaces are generated via a continuous, uninterrupted sequence of laser pulses. A treatment device is disclosed with at least one eye surgical laser for the separation of a predefined corneal volume with predefined interfaces of a human/animal eye by photodisruption and with at least one control device for the laser(s).

An ultrasonic processing apparatus is provided. The ultrasonic processing apparatus comprises an ultrasonic therapy transducer (ATA) adapted to generate focused ultrasonic waves; an ultrasonic imaging transducer (UID) connected to the ultrasonic therapy transducer; and an electronic system configured to control the ultrasonic therapy transducer so as to emit a pulse train of ultrasonic waves generating a cloud of cavitation bubbles (BC); control the ultrasonic imaging transducer so as to acquire at least one image of the region to be processed; acquire a plurality of echo signals of ultrasonic wave pulses emitted by the ultrasonic therapy transducer captured by the ultrasonic imaging transducer; process the plurality of echo signals so as to reconstruct an image of the cloud of cavitation bubbles; and display said image of the cloud of cavitation bubbles superposed on said image of the region to be processed. The processing includes spatio-temporal filtering.

Hyperspectral videostroboscopy imaging is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to cause the emitter to emit the pulses of electromagnetic radiation at a strobing frequency determined based on a vibration frequency of vocal cords of a user. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 513 nm to about 545 nm, from about 565 nm to about 585 nm, or from about 900 nm to about 1000 nm.