The present invention describes systems and methods for treating mitral valve regurgitation. The treatment includes a systems and method of modifying the mitral valve by attaching a device to each leaflet and pulling them toward each other to stop mitral valve regurgitation.

During a medical procedure, a transseptal fenestration is made at a septum of the heart and a shunt is implanted into the transseptal fenestration. During the same medical procedure, a transapical puncture is made into a left ventricle of the heart. A prosthetic valve is delivered via the transapical puncture and implanted at a mitral valve of the heart. Subsequently to delivering the prosthetic valve and making the transseptal fenestration, the transapical puncture is closed. Other embodiments are also described.

A neostomy apparatus, including a grasping device, a cutting device and a control handle. The control handle includes a housing and a manipulation portion disposed in the housing, the manipulation portion can move axially relative to the housing; the grasping device or the cutting device includes an elongated member, and the manipulation portion drives the elongated member to move axially; the elongated member is partially located in the housing, and a first limiting structure is further disposed in the housing, the first limiting structure has a groove or a through hole, and a portion of the elongated member located in the housing is at least partially disposed in the groove or the through hole of the first limiting structure.

Medical guidewire assembly is movable through guidewire introducer positionable proximate to a biological wall located within the body of a patient. Medical guidewire assembly has flexible distal shaft section configured to extend along the guidewire introducer. Medical guidewire assembly has a predetermined spatial geometry once the flexible distal shaft section is removed from guidewire introducer. Medical guidewire assembly also has a piercing stylet device configured to puncture the biological wall in response to placement of guidewire introducer (in use) proximate to the biological wall, and movement of the flexible distal shaft section through the guidewire introducer. The predetermined spatial geometry is configured to prevent physical contact between the piercing stylet device and adjacently positioned tissue of the patient in response to formation of the predetermined spatial geometry.

A medical guidewire assembly is movable through an exit portal of a guidewire introducer. The guidewire introducer and the medical guidewire assembly are each insertable, at least in part, into a patient. The medical guidewire assembly is configured to reduce, at least in part, the hoop stress surrounding a puncture hole extending through the tissue of the patient. This is done in response to movement, at least in part, of the medical guidewire assembly relative to the puncture hole (after the puncture hole has been initially formed).

A method is provided for puncturing a fossa ovalis of a heart, the method including inserting a catheter into a right atrium of the heart, and advancing a distal portion of the catheter toward an interatrial septum of the heart. A flexible longitudinal member is slid through openings disposed at the distal portion of the catheter, such that the flexible longitudinal member is made to loop around a portion of an inside perimeter of the fossa ovalis. While the flexible longitudinal member is looped around the portion of the inside perimeter of the fossa ovalis, a hole is punctured in the fossa ovalis at a puncturing point.

The present disclosure provides a variety of prostheses, delivery systems and techniques to facilitate closure of transvascular or transcameral access ports. Various embodiments of prostheses are provided including a plurality of radially expandable discs that can be filled with material to facilitate coagulation and to reduce or stop leakage from punctures in vessel walls.

Systems, devices, and methods for providing access to the heart. The system includes an intracardiac access device comprising an elongate member having a channel extending between a distal end and a proximal end thereof. The intracardiac access device is configured to be advanced through an extrapericardial penetration in the left atrial wall without penetrating the pericardium of the heart. An optional procedural device is configured to be advanced through the channel of the intracardiac access device into an internal chamber of the heart and configured to perform a surgical procedure in the internal chamber of the heart. A working channel of an optional suprasternal access device is configured to facilitate access of the intracardiac access device into the body of the patient by providing a path from a suprasternal opening to a position adjacent the roof of the left atrium.

An expansion body that radially expands and contracts; an elongated shaft portion having a distal portion including a proximal end fixing portion to which a proximal end of the expansion body is fixed; a plurality of electrode portions provided along the expansion body are included, and the expansion body includes a recess portion recessed radially inward when the expansion body expands and defining a reception space that receives a biological tissue. The recess portion includes a bottom portion positioned at a radial innermost side, a proximal side upright portion extending radially outward from a proximal end of the bottom portion, and a distal side upright portion extending radially outward from a distal end of the bottom portion. One of two electrode portions that are circumferentially adjacent to each other is arranged at the proximal side upright portion, and the other is arranged at the distal side upright portion.

A septal cross system is provided for a cerclage procedure for treating dysfunctional heart. The cerclage septal cross system includes a puncture catheter and a capture catheter. The puncture catheter a puncture catheter comprises a first lumen for a guidewire to be inserted thereinto. A coil element is arranged in the distal portion of the puncture catheter. The distal end of the pull-wire is attached to the distal portion of the coil element. The proximal end of the pull-wire is extended to the distal portion of the puncture catheter. The pull-wire is configured to bend inwardly the distal portion of the puncture catheter. A capture catheter comprises a first lumen for a first guidewire to be inserted thereinto and a second lumen for a second guidewire to be inserted thereinto. The distal end of the second wire has a snare wherein the distal portion is deflectable.