A device includes a housing having a first opening for receiving tissue therein and a distal head disposed at least partly within the housing. The distal head is configured to rotate about a longitudinal axis of the distal head. The device also includes a first holding member coupled to the housing and a second holding member coupled to the distal head. The first and second holding members are configured so that rotating the distal head stretches a first ligation band coupled to the first and second holding members, permitting tissue drawn into the first opening to pass through an opening of the first ligation band.

Disclosed are methods and devices for endocardial left atrial appendage management (LAAM) by inversion and excision. The methods may comprise inserting an inverter apparatus into an interior cavity of the left atrial appendage (LAA) of a subject and inverting the LAA, closing the base portion of the inverted LAA with the one or more closure devices, separating the inverted LAA from the left atrium with a separation apparatus positioned at the base portion of the inverted LAA adjacent to the one or more closure devices, and removing the separated LAA from the subject.

The present invention is an apparatus and method for ligation. The ligation apparatus or band provides topical active agent(s) that alleviate pain during various ligature procedures. This invention also relates to a method that includes applying a loop or band around a body part for elastomeric ligation, whereby the band material supplies a topical active agent (s) to the body part to reduce the pain of ligation.

The present invention is an apparatus and method for ligation of livestock animals. The ligation apparatus or band provides topical active agent(s) that alleviate pain during various ligature procedures. This invention also relates to a method that includes applying a loop or band around a body part for elastomeric ligation, whereby the band material supplies a topical active agent (s) to the body part to reduce the pain of ligation.

An apparatus includes a plurality of beads. Each bead includes a housing and a magnet positioned within the housing. The apparatus also includes a plurality of interconnection elements. Each interconnection element movably joins together a corresponding pair of beads. The plurality of beads and the plurality of interconnection elements are sized and configured to form an expandable loop around an anatomical structure in a patient. The expandable loop is configured to apply a constrictive force to the anatomical structure. The constrictive force has a first rate of change when a dilation ratio of the expandable loop is within a first range, a second rate of change when the dilation ratio of the expandable loop is within a second range, and a third rate of change when the dilation ratio of the expandable loop is within a third range.

Devices, methods, and systems are provided for consistent and effective delivery of ligating bands. In one embodiment, a crisscross orientation of pull cords along an exterior surface of a ligation barrel can be used to ensure consistent delivery of ligation bands to tissue, resulting in better results for patients and an easier, safer operation for users.

A left atrium appendage (LAA) isolator, including: a body sized and shaped to fit an at least partially inverted LAA of a human adult, wherein a distal end of said body defines a two-state sealing adaptor interface configured in a first state to apply a radially outward force against a wall of said LAA or against a wall of said LAA opening sufficient to anchor said body to the LAA wall, and in a second state the sealing adaptor interface is configured to apply a radially inward force on a portion of the inverted LAA positioned within said body.

An apparatus includes a plurality of beads and a plurality of interconnection elements. Each bead includes a housing and a magnet. Each interconnection element includes a main body extending between a pair of ends, and a pair of heads each positioned at a respective end and received within a bead. The beads and interconnection elements are sized and configured to form a loop configured to transition between constricted and expanded configurations. The apparatus is configured such that, when the loop is in the expanded configuration, a first head of a first interconnection element is received within a first bead and is spaced apart from a first centerline of the first bead by a first distance, and a second head of a second interconnection element is received within a second bead and is spaced apart from a second centerline of the second bead by a second distance.

An apparatus includes a plurality of beads. Each bead of the plurality of beads includes a housing and a magnet positioned within the at least one housing. The apparatus also includes a plurality of interconnection elements. Each interconnection element movably joins together a corresponding pair of beads. Each interconnection element includes a composite material. The plurality of beads and the plurality of interconnection elements are sized and configured to form a loop around an anatomical structure in a patient. The loop formed by the plurality of beads and the plurality of interconnection elements is configured to transition between a constricted configuration and an expanded configuration. The loop in the constricted configuration is configured to prevent fluid flow through the anatomical structure. The loop in the expanded configuration is configured to permit fluid flow through the anatomical structure. The magnets are configured to magnetically bias the loop toward the constricted configuration.

A method of manufacturing a bead assembly for a sphincter augmentation device includes initiating 3D printing of a unibody housing such that the unibody housing defines a first opening, a chamber, and a magnet chamber. The method further includes pausing the 3D printing process, inserting a magnet within the magnetic chamber, and then resuming 3D printing of the unibody housing to form a hermetic seal between the magnet chamber and an external surface of the unibody housing.