Left atrial occlusion devices and methods of occluding a left atrial appendage. The left atrial occlusion devices can be carried by a flexible elongate member, have an inflatable member, and have a plurality of flexible elongate implant members forming a distally open cage configuration when expanded. The implant members have a flexible format to allow them to conform to the anatomy of the left atrial appendage. The distal ends of the flexible elongate member can optionally be atraumatic.

Consistent with disclosed embodiments, systems, devices, methods, and computer readable media for delivery of an endovascular instrument to a treatment site within a body may be provided. Embodiments may include a flexible, elongated sheath having a proximal end and a distal end. An embodiment may further include an inner wall of the sheath delimiting an inner lumen which may extend between the proximal end and the distal end of the sheath. The inner lumen may be sized to enable axial advancement of the endovascular instrument therethrough. The embodiments may also include at least one electrode within the distal section of the sheath. The electrode may be configured to selectively deliver an electric current through a segment of the endovascular instrument within the inner lumen.

Consistent with disclosed embodiments, systems, devices, methods, and computer readable media for filling a hollow body structure may be provided. In some implementations, an endovascular instrument for filling a hollow body structure may be provided and may include an elongated member configured to exhibit differing coiling properties along a length thereof. The elongated member may include a first region configured to bend within the hollow body structure to form a stabilizing frame. The elongated member may also include a second region located proximal to the first region and configured to bend, after formation of the frame, substantially within the frame, thereby forming a curved mass substantially within the frame. The first region and the second region may be interconnected. The embodiments may further include at least one structural property that differs between the first region and the second region.

A medical system may include a left atrial appendage closure device including an expandable framework and a proximal hub disposed along a central longitudinal axis of the expandable framework, the expandable framework being configured to shift between a collapsed delivery configuration and an expanded deployed configuration; wherein the left atrial appendage closure device includes a sensor at least partially disposed within an interior of the expandable framework and axially movable relative to the proximal hub; wherein the proximal hub includes a first threaded connection structure; and a delivery catheter including a core wire extending axially within a lumen of the delivery catheter, the core wire having a second threaded connection structure at a distal end thereof configured to releasably engage the first threaded connection structure in an unreleased configuration and the second threaded connection structure is disengaged from the first threaded connection structure in a released configuration.

Consistent with disclosed embodiments, systems, devices, methods, and computer readable media for monitoring and facilitating endovascular coil delivery may be provided. Embodiments may include obtaining a first input from a coil movement sensor associated with an endovascular coil within a lumen of a catheter positioned within a body. The catheter may include a coil partitioning mechanism configured to sever the endovascular coil. Embodiments may further include obtaining a second input to activate the coil partitioning mechanism. Embodiments may further include activating, in response to the second input, the coil partitioning mechanism to sever the endovascular coil into a first coil section for delivery and a residual second coil section. Embodiments may further include determining, based on at least the first input and the second input, a length of the second coil section and outputting a signal based on the determined length of the second coil section.

An endovascular device, including an elongated flexible sheath defining a lumen with an inner opening sized for enabling selective advancement of an endovascular instrument therethrough, the sheath having at least a first region and a second region; an electrode within the first region of the sheath; and a constrictor associated with the first region of the sheath, the constrictor being configured, while at least the first region and the second region of the sheath are positioned within a body and in response to an input received from outside the body, to reversibly narrow the lumen of the sheath in an area adjacent the electrode to thereby bring the electrode into contact with an adjacent portion of the endovascular instrument.

An endovascular apparatus, including an elongated catheter having an inner lumen extending therethrough; a balloon affixed to the catheter for expansion into the inner lumen of the catheter when the balloon is inflated; and a tube secured relative to the balloon, wherein the tube is configured to enable selective inflation and deflation of the balloon, and wherein an outer diameter of a portion of the catheter adjacent the balloon is substantially the same when the balloon is inflated and when the balloon is deflated.

Consistent with disclosed embodiments, systems, devices, methods, and computer readable media for delivery of an endovascular instrument to a treatment site within a body may be provided. Embodiments may include a flexible, elongated sheath having a proximal end and a distal end. An embodiment may further include an inner wall of the sheath delimiting an inner lumen which may extend between the proximal end and the distal end of the sheath. The inner lumen may be sized to enable axial advancement of the endovascular instrument therethrough. The embodiments may also include at least one electrode within the distal section of the sheath. The electrode may be configured to selectively deliver an electric current through a segment of the endovascular instrument within the inner lumen.

An endovascular device, including an elongated flexible sheath defining a lumen with an inner opening sized for enabling selective advancement of an endovascular instrument therethrough, the sheath having at least a first region and a second region; an electrode within the first region of the sheath; and a constrictor associated with the first region of the sheath, the constrictor being configured, while at least the first region and the second region of the sheath are positioned within a body and in response to an input received from outside the body, to reversibly narrow the lumen of the sheath in an area adjacent the electrode to thereby bring the electrode into contact with an adjacent portion of the endovascular instrument.

Consistent with disclosed embodiments, systems, devices, methods, and computer readable media for monitoring and facilitating endovascular coil delivery may be provided. Embodiments may include obtaining a first input from a coil movement sensor associated with an endovascular coil within a lumen of a catheter positioned within a body. The catheter may include a coil partitioning mechanism configured to sever the endovascular coil. Embodiments may further include obtaining a second input to activate the coil partitioning mechanism. Embodiments may further include activating, in response to the second input, the coil partitioning mechanism to sever the endovascular coil into a first coil section for delivery and a residual second coil section. Embodiments may further include determining, based on at least the first input and the second input, a length of the second coil section and outputting a signal based on the determined length of the second coil section.