A system for hepatic nerve denervation includes a medical device and a generator in communication with the medical device. The medical device includes an elongate body having a proximal portion and a distal portion opposite the proximal portion, and a plurality of treatment electrodes coupled to the distal portion. The distal portion is configured to be in contact with an area of target tissue. The area of target tissue is an area of tissue within the hepatic artery. The generator is configured to generate and deliver at least one pulse train of energy to the plurality of treatment electrodes to ablate the area of target tissue.

A catheter, consisting of an insertion probe, having a distal end configured for insertion into a lumen of a human subject. The catheter also has a resilient tube, extending distally from the distal end of the insertion probe and having, when unconstrained, a planar serpentine shape contained within a plane that contains a longitudinal axis of the distal end of the insertion probe. A plurality of electrodes are fixedly attached to the resilient tube and are configured to transfer ablation energy to the human subject. Other shapes for the insertion tube are also provided.

The invention generally relates to systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition.

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods includes evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

The invention generally relates to systems and methods for therapeutically modulating nerves in or associated with a nasal region of a patient for the treatment of a rhinosinusitis condition.

Computer-implemented digital image analysis methods, apparatuses, and systems for robotic installation of surgical implants are disclosed. A disclosed apparatus plans a route within an anatomy of a patient from an incision site to a surgical implant site for robotic installation of a surgical implant. The apparatus uses digital imaging data to identify less-invasive installation paths and determine the dimensions of the surgical implant components being used. The apparatus segments the surgical implant into surgical implant subcomponents and modifies the surgical implant subcomponents, such that they can be inserted using the identified less-invasive installation paths.

The present invention provides a method for treating diabetes and nonalcoholic fatty liver disease (NAFLD), associated condition or disorder thereof, or symptoms thereof suffered by a subject such as a mammal (e.g. a human patient or a pet), comprising (1) placing one or more electrodes within a target blood vessel of the subject and against the target blood vessel wall, wherein the target blood vessel includes the celiac artery and/or a segment of the abdominal aorta terminated at its junction with the celiac artery; (2) adhering a surface electrode on an external surface such as skin of the subject; and (3) releasing a therapeutically effective amount of radiofrequency energy through the one or more electrodes to nearby tissues, so as to increase the temperature of the nearby tissues and induce a thermal alteration of the nearby tissues.

A catheter for denervation includes a catheter body extending in one direction to have a proximal end and a distal end and having an inner space formed along the longitudinal direction thereof, a movable member provided at the distal end of the catheter body to be movable along the longitudinal direction of the catheter body, an operating member having a distal end connected to the movable member to move the movable member, a plurality of support members having one end connected to a terminal of the catheter body and the other end connected to the movable member, wherein when the movable member moves to decrease a distance between the terminal of the catheter body and the movable member, at least a partial portion of the plurality of support members is bent so that the bending portion moves away from the catheter body, a plurality of electrodes respectively provided at the bending portion of the plurality of support members to generate heat, and a lead wire respectively electrically connected to the plurality of electrodes to give a power supply path for the plurality of electrodes.

A catheter-mounted balloon includes an inflatable chamber defining a volume expandable from a deflated state to an inflated state, the inflatable chamber having a distal transition portion, a proximal transition portion, and a cylindrical body portion disposed between the distal transition portion and the proximal transition portion. The cylindrical body portion of the inflatable chamber includes a pleat zone having a pleat when the inflatable chamber is in the deflated state. The catheter-mounted balloon further includes an electrode disposed along a wall of the inflatable chamber. The pleat traverses the electrode such that is electrode is pleated as well.

Systems and methods for assessing sympathetic nervous system (SNS) tone for renal neuromodulation therapy are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a detector attached to or implanted in a patient and a receiver communicatively coupled to the detector. The detector can measure cardiac data and the receiver and/or a device communicatively coupled thereto can analyze the cardiac data to provide one or more SNS tone indicators. The SNS tone indicators can be used to determine whether a patient will be responsive to a neuromodulation therapy and/or whether a neuromodulation therapy was effective.