A laser system includes a first laser configured to generate a laser light, the first laser light including a first wavelength, a second laser configured to generate a second laser light, the second laser light including a second wavelength different from the first wavelength, and a laser fiber operatively coupled to each of the first laser and the second laser to emit at least one of the first laser light or the second laser light at a target site.

The device comprises: a laser source (7); a treatment hand-piece (13); a light guide (11) configured to convey a laser beam from the laser source to the hand-piece. The hand-piece (13) is configured to vary the inclination of the laser beam (F2) exiting from the hand-piece with respect to a longitudinal axis (A-A) of the hand-piece.

The invention provides systems and method for the removal of diseased cells during surgery

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

The invention provides systems and method for the removal of diseased cells during surgery.

According to an embodiment of the present disclosure, an optical output control device includes: a wavelength-selective reflector configured to reflect light in a predetermined wavelength band and incident at a reference angle θ.sub.c; and a driving unit configured to rotate the wavelength-selective reflector to adjust an angle of incidence of light incident on the wavelength-selective reflector.

The present disclosure is directed to systems and methods that facilitate delivery of a therapeutic agent into the skin of a subject. A first mechanism can create a first angled channel through a first location on a surface of a subject's skin at a first angle relative to the surface of the subject's skin. A second mechanism, associated with the first mechanism, can create a second angled channel through a second location on the surface of the subject's skin at a second angle relative to the surface of the subject's skin. The first angled channel and the second angled channel intersect to form a connected channel under the surface of the subject's skin.

A trans-oral surgery device has a scaffold insertable into the vicinity of the larynx or hypopharynx of a subject. A support is arranged for holding a flexible optical fiber for delivering light to the subject. A plurality of tendons is connected to the support, and slidably anchors the support to the scaffold. The tendons are adjustable to move the support relative to the scaffold. The scaffold is provided at the front end of a blade, and the blade is non-straight.

A surgical probe is configured to be inserted into a body cavity and to emit beams of light to ablate tissue within the body cavity. The probe further includes sensors to detect properties of tissue in the body cavity and a source of suction to remove material produced by ablation of tissue within the body cavity. The sensors could be configured to operate in combination with beams of light emitted by the surgical probe to detect the location, geometry, fluorophore content, or other information about tissue in the body cavity. The surgical probe can additionally include suction port(s) to secure portions of tissue relative to the surgical probe to allow ablation of portions of the secured tissue and to allow detection of properties of portions of the secured tissue that are maintained in contact with the surgical probe by the suction port(s).

Provided and described herein are exemplary embodiments of apparatus, system, computer-accessible medium, procedure and method according to the present disclosure which can be used for providing laser steering and focusing for, e.g., incision, excision and/or ablation of tissue in minimally-invasive surgery. For example, an exemplary apparatus is provided that can include at least one optical element which can be configured to refract and/or diffract light provided in a structure which can be configured to be inserted into a body, where at least one of the optical element(s) is structured to receive the light at a first angle and generate a refracted and/or diffracted light at a second angle which can be different from the first angle relative to an optical axis. According to a particular exemplary embodiment of the present disclosure, an exemplary actuating arrangement can be provided, which can be configured to control the optical element(s), can be provided and situated at least partially within the at least one structure.