A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. A subject's skin can be altered to facilitate absorption of applied substances. A substance can be applied to altered skin so that the substance is absorbed into the skin. The treatment site can be cooled to initiate a freeze event in the skin to freeze tissue. The substance can be a coupling media that promotes or inhibits freezing of tissue.

A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. An applicator is then applied to the subject to cool a region of the subject. After cooling the tissue, a nucleation initiator is used to initiate a freeze event in the tissue. The nucleation initiator can be an ice crystal that inoculates the skin upon contact to create a predictable freeze event therein. The time of contact between the ice crystal and the skin can be controlled to achieve desired effects.

A method and system in accordance with particular embodiments includes applying a substance onto skin of a human subject. A method for treating a subject's skin includes applying a hydrogel to the skin which contains the substance. The hydrogel and the skin are cooled using a cooling applicator to treat tissue via the cooling treatment by either freezing or not freezing tissue.

A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. The applied substance can include a freezing point depressant and a liposome, an oil-in-water emulsion, a water-in-oil emulsion, or an oil-in-oil emulsion and can be configured to protect or target tissue. The substance and a surface of the skin can be cooled using the applicator to treat acne and other skin conditions.

The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for locating and treating a target nerve with integrated cold therapy and electrical stimulation systems are provided. For example, nerve stimulation and cryoneurolysis may be delivered concurrently or alternately with the cryo-stimulation device. In some embodiments, the device may be operated by a single operator or clinician. Accordingly, embodiments of the present disclosure may improve nerve targeting during cryoneurolysis procedures. Improvements in nerve localization and targeting may increase treatment accuracy, physician confidence in needle placement during treatment, and clinical efficacy and safety. In turn, such improvements may decrease overall treatment times, the number of repeat treatments, and the re-treatment rate. Further, additional improvements in nerve localization and targeting may reduce the number of needle insertions, applied treatment cycles, and may also reduce the number of cartridge changes.

The present disclosure is directed to a method of performing a photo-thermal dermatological procedure without use of an injectable anesthetic. The method includes applying a topical anesthetic to a treatment area of skin, measuring a surface temperature of the treatment area of skin, and passing a stream of cold air over the area of skin such that the surface temperature of the treatment area of skin is maintained between 0 degrees Celsius and 15 degrees Celsius for a duration of at least 30 seconds. The method further includes administering a photo-thermal energy dose to the area of skin after the duration.

The illustrated embodiments include an apparatus to reduce or eliminate full thickness injury in tissue and to deform tissue which includes a probe or mechanism for deforming tissue, and a subsystem for selectively cooling and/or heating tissue while deformation is of the tissue is being performed. The illustrated embodiments of the invention also extend to a method to reduce or eliminate full thickness injury in tissue and to deform tissue including the steps of deforming tissue, and selectively cooling and/or heating tissue while deformation of the tissue is being performed.

A method and apparatus are disclosed for preventing injury to an esophagus caused by heat or cold being delivered to the left atrium, the method including altering a heat exchange device from an insertable configuration to a heat exchanging configuration which has an inflated generally flattened cross section (e.g. capsule-shaped, elliptical) corresponding with the cross section of the inside of the esophagus such that the esophagus is maintained in its natural shape and location. In some embodiments the heat exchange device has a heat exchanger which is inflated to be in the heat exchanging configuration.

A tissue displacement/separation device includes a seamless bladder constructed of a biodegradable polymer. The bladder is expandable from a collapsed or rolled state for insertion into a body between a first and second tissue to an expanded state for separating the first and second tissue.

Disclosed is a frostbite prevention pad for a cryolipolysis procedure, which is used for a cryolipolysis procedure using a cryolipolysis device. The frostbite prevention pad includes: a base member made of a fiber material; one or more waterproof members made of a resin material and placed to overlap the base member; and one or more sewn parts formed by sewing the base member and the waterproof member to couple the base member and the waterproof member in a state in which the base member and the waterproof member overlap each other.