The present invention provides a cold solution and method for treating obstructive sleep apnea. The cold solution can comprise liquid and/or solid ice particles. In one embodiment, the method comprises delivering a cold solution to target tissue where the target tissue can be fat tissue located in one or more of an airway, a neck, a thorax, a diaphragm, a face, or an abdomen.

The present invention provides methods and devices for controlling a cold slurry that is delivered to a target tissue and for limiting heat transferring from surrounding tissue to the target tissue. In particular, a balloon structure is deployed at or near a point of delivery to act as a physical and/or thermal barrier. In some instances, the balloon structure can act as a pressure device obstructing the flow of warm blood into a treatment area, which can melt the cold slurry.

Methods, devices, and systems for treatment and removal of skin lesions, such as skin tags, are disclosed herein. In at least one embodiment, a system for treating a skin lesion comprises: a tweezer comprising a treatment region; and an activation station, the activation station configured with a first receiving end and a second receiving end. In at least one embodiment, the activation station receives the tweezer at the first receiving end, and receives a cryogenic agent at the second receiving end. The first receiving end is fluidly coupled to the second receiving end to facilitate delivery of the cryogenic agent to the treatment region of the tweezer.

A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. The applied substance can include a freezing point depressant and a liposome, an oil-in-water emulsion, a water-in-oil emulsion, or an oil-in-oil emulsion and can be configured to protect or target tissue. The substance and a surface of the skin can be cooled using the applicator to treat acne and other skin conditions.

Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance sites with cellulite. Treatments can include cooling a surface of a patient's skin and detecting freezing in the cooled skin. The tissue can be cooled after the freeze event is detected so to maintain the frozen state of the tissue to improve the appearance of the treatment site.

A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. An applicator is then applied to the subject to cool a region of the subject. After cooling the tissue, a nucleation initiator is used to initiate a freeze event in the tissue. The nucleation initiator can be an ice crystal that inoculates the skin upon contact to create a predictable freeze event therein. The time of contact between the ice crystal and the skin can be controlled to achieve desired effects.

A system includes a connector with a central lumen. A multi-lumen chamber is removably connected to and in fluid communication with a proximal end of the central lumen. The multi-lumen chamber includes a first lumen aligned and adjacent a second lumen. The first lumen includes a first fluid in a proximal portion of the first lumen and a hydrophilic polymer in a distal portion of the first lumen, a first plunger rod within the first lumen to control flow of the first fluid into the distal portion to mix with the hydrophilic polymer in a first state to form a first mixture, and a first port. The second lumen includes a second fluid, a second plunger rod within the second lumen to distally move the second fluid and the first mixture in a second state, and a second port.

Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquid—e.g., a liquid or air—is applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

Mechanical biomimicry translator. Epidermal lesion-removal triage-platform. Present invention cryotreats humanity suffering from benign basal-cell to aggressive, malignant, oncological lesions. Hand-held, artisan-styled monoframe. Prosthetic Blitzkrieg processing. Dermatology-tool.

Deployment eviscerates common histological abnormalities. Holographic Skeletal-Reflex Exoframe. Clinical. Metered. Structured. 360° rotate/ablate. Backbone. Glide-rails. Asymmetrical, gain-of-function; filtration-membrane.

Ground-zero; mobile directed-energy-matrix. Level-2 Spec-Ops-7. Digital encoder modulates/dispenses 3.sup.rd party biologics. Multi-factor authentication; oncological, epidemiological, gynecological; Gender-balanced. L.G.B.T.Q.I.A+ compatible. Agnostic. Mercy-Aid. NGO.

Rapid-Defense, Rapid-Offense-Procedures. De-risking cryodestruction. Multi-mission capable; first-aid, mobile family-medicine; medical-tourism. Pocket-Sherpa form-factor. Panoramic lesion harvesting. Recyclable.

Essential acute-care; lowering patientcare costs. Inclusion, diversity, equity, action. Uncompromising mitigation strategy. Comprehensive menu, human-performance enhancements democratizing open-source, Krieger-Amulet-TaaS®. Plug and play cold-fusion cryosurgery. Interdiction-Consumer-Empowerment. Humanitarians without borders. Patient-Lives-Matter.

A protective assembly for use during laparoscopic surgery, the assembly comprising: a thin membrane formed from non-toxic material, the membrane being sufficiently thin and maneuverable to be passed through a cannula of a trocar; a flexible connector extending from the thin membrane; and an insertable shaft dimensioned to be passed through the cannula wherein a distal portion of the shaft is anchored to the flexible connector.