An endoscopic vessel harvesting system for surgical removal of a blood vessel to be used for coronary bypass uses endoscopic instruments for isolating and severing the vessel. An endoscopic camera in the endoscopic instruments captures images from a distal tip of the instrument within a dissected tunnel around the vessel. An image processor assembles a three-dimensional model of the tunnel from a series of images captured by the endoscopic camera. An augmented-reality display coupled to the image processor renders (e.g., visibly displays to the user in their field of view) a consolidated map representing the three-dimensional model along with a marker in association with the map indicating a current location of the distal tip.

A method for performing a procedure on a patient includes acquiring a three-dimensional image of a location of interest on the patient and a two-dimensional image of the location of interest can be acquired. A computer system can relate the three-dimensional image with the two-dimensional image to form a holographic image dataset. The computer system can register the holographic image dataset with the patient. The augmented reality system can render a hologram based on the holographic image dataset from the patient. The hologram can include a projection of the three-dimensional image and a projection of the two-dimensional image. The practitioner can view the hologram with the augmented reality system and perform the procedure on the patient. The practitioner can employ the augmented reality system to visualize a point on the projection of the three-dimensional image and a corresponding point on the projection of the two-dimensional image during the procedure.

The method of locating at least one mobile perception device of a navigation platform, the mobile perception device intended to be worn or carried by a user in a surgical scene, the navigation platform including at least one perception sensor, comprises: —acquiring, by the at least one perception sensor, a plurality of successive images of the scene including the portion of the body of the patient intended to be subjected to the surgical operation; —processing the plurality of successive images to evaluate a relative position of the mobile perception device and the portion of the body intended to be subjected to the surgical operation, wherein the relative position of the mobile perception device and the portion of the body takes into account a movement of the mobile perception device.

The method of fitting a knee prosthesis in a knee of a patient includes displaying, by a visual display device of a mobile augmented reality navigation system worn or carried by a user performing or assisting at least one navigation-assisted stage of the method, at least one visual element superposed on a view of at least a portion of a surgical scene of the fitting of the knee prosthesis. The visual element can be a 3D model of at least one portion of the knee of the patient, a 3D model of another component of the surgical scene, information relative to the at least one portion of the knee of the patient, and/or information relative to the other component of the surgical scene.

A virtual reality system providing a virtual robotic surgical environment, and methods for using the virtual reality system, are described herein. Within the virtual reality system, various user modes enable different kinds of interactions between a user and the virtual robotic surgical environment. For example, one variation of a method for facilitating navigation of a virtual robotic surgical environment includes displaying a first-person perspective view of the virtual robotic surgical environment from a first vantage point, displaying a first window view of the virtual robotic surgical environment from a second vantage point and displaying a second window view of the virtual robotic surgical environment from a third vantage point. Additionally, in response to a user input associating the first and second window views, a trajectory between the second and third vantage points can be generated sequentially linking the first and second window views.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Navigation assistance systems and methods for use with a surgical instrument to assist in navigation of a surgical instrument during an operation. The system may include sensors that may observe the patient to generate positioning data regarding the relative position of the surgical instrument and the patient. The system may retrieve imaging data regarding the patient and correlate the imaging data to the positioning data. In turn, the position of the surgical instrument relative to the imaging data may be provided and used to generate navigation date (e.g., position, orientation, trajectory, or the like) regarding the surgical instrument.

Various embodiments of a physical instrument are described herein. The physical instrument comprises a reference array platform having a top surface and a bottom surface. A reference array including one or more different fiducial markers is disposed on the top surface of the reference array platform. The reference array platform may have a bent physical configuration or a tilted physical configuration. An adhesive layer is disposed on the bottom surface of the reference array platform.

An example method includes obtaining, a virtual model of a portion of an anatomy of a patient obtained from a virtual surgical plan for an orthopedic joint repair surgical procedure to attach a prosthetic to the anatomy; identifying, based on data obtained by one or more sensors, positions of one or more physical markers positioned relative to the anatomy of the patient; and registering, based on the identified positions, the virtual model of the portion of the anatomy with a corresponding observed portion of the anatomy.

Disclosed are systems, methods, and techniques for registering a HMD coordinate system of a head-mounted display (HMD) and a localizer coordinate system of a surgical navigation localizer. A camera of the HMD captures at least one image of a registration device having a registration coordinate system and a plurality of registration markers. The registration markers are analyzed in the at least one image to determine a pose of the HMD coordinate system relative to the registration coordinate system. One or more position sensors comprised in the localizer detect a plurality of tracking markers comprised in the registration device to determine a pose of the registration coordinate system relative to the localizer coordinate system. The HMD coordinate system and the localizer coordinate system are registered using the registration device, wherein positions of the registration markers are known with respect to positions of the tracking markers in the registration coordinate system.