A system for obtaining biomechanical parameters of ocular tissue includes an air-puff module to deliver an air-puff stimulus onto the ocular tissue, and an imaging device operatively coupled to the air-puff module.

The air-puff module includes a transparent window at its front with a transparent through hole for delivering the air-puff stimulus. The hole is aligned with an imaging device optical axis, such that the air-puff stimulus delivered onto the ocular tissue can be centred on an apex of the ocular tissue and made collinear with the optical axis. The transparent window and through hole allow continuity of imaging of the ocular surface.

The imaging device captures the 3D coordinates of points distributed on an ocular tissue surface in groups of simultaneous points.

The system includes a component for selecting and changing location and distribution of captured points on the ocular tissue, and a processing component to process the points.

Peripheral retinal OCT can be used to generate peripheral retinal OCT images allowing for the peripheral retina to be viewed. A peripheral retinal vision system can determine that a set of fiducial markers is in a field-of-view of at least one camera and record positional data comprising a contact lens position and angle with respect to an OCT imaging system having OCT scanning mirrors in a first position. The system can determine whether a retinal layer is in an OCT scan captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position; and for an OCT scan having he retinal layer and being captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position, store that OCT scan.

An ophthalmic information processing apparatus includes a specifying unit and an image deforming unit. The specifying unit is configured to specify a three-dimensional position of each pixel in a two-dimensional front image depicting a predetermined site of a subject's eye, based on OCT data obtained by performing optical coherence tomography on the predetermined site. The image deforming unit is configured to deform the two-dimensional front image, by changing position of at least one pixel in the two-dimensional front image based on the three-dimensional position, to generate a three-dimensional front image.

Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time.

Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

Systems and methods are provided for measuring the mechanical properties of ocular tissue, such as the lens or corneal tissue, for diagnosis as well as treatment monitoring purposes. A laser locking feedback system is provided to achieve frequency accuracy and sensitivity that facilitates operations and diagnosis with great sensitivity and accuracy. Differential comparisons between eye tissue regions of a patient, either on the same eye or a fellow eye, can further facilitate early diagnosis and monitoring.

A hand-held sized ocular and neurological screening device, system and method, the screening device comprising an eyepiece and a hand-held housing, the housing comprising a tubular stimulus chamber defining a light stimulus channel, wherein an illumination source is configured to provide light stimulus towards an opening through the light stimulus channel and an operational chamber comprising an infrared camera positioned outside the stimulus channel and inclined towards the opening, the infrared camera is configured to capture images of the pupils and eye movements through the opening without interfering with the light stimulus and a controller configured to receive the captured images from the infrared camera. The hand-held sized device can include a clip-on fixture for fixing the device onto a table, a desktop, or any portable ophthalmic apparatus.

An implementation cost of a line-scan optical coherence tomography (OCT) apparatus is reduced by miniaturizing a scanning mirror and using a light source with relaxed requirement in intensity uniformity. The mirror reflects a probe light beam to different parts of a sample for line-scanning the sample. A line-compressing lens compresses the probe light beam's cross-sectional length before the beam reaches the mirror, allowing the mirror to be miniaturized to reflect only the compressed beam. In generating a linear light beam that gives the probe light beam, a cascade of collimating lens, Powell lens and focusing lens generates the linear light beam from a raw light beam of a point source. A slit further filters the linear light beam to remove a peripheral portion thereof such that the linear light beam is substantially uniform in intensity even if an asymmetrical divergent light source is used.

Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.

An image processing method performed by a processor and including detecting positions of plural vortex veins in a fundus image of an examined eye, and computing a center of distribution of the plural detected vortex vein positions.