The present disclosure is directed to systems and methods for measuring and analyzing pupillary psychosensory responses. An electronic device is configured to receive video data with at least two frames. The electronic device then locates one or more eye objects in the video data and determine pupil and iris sizes of the one or more eye objects. The electronic device determines the pupillary psychosensory responses of the one or more eye objects by tracking a ratio of pupil diameter to iris diameter throughout the video. Several metrics for the pupillary psychosensory responses can be determined (e.g., velocity of change of the ratio, peak to peak amplitude of the change in ratio over time, etc.). These metrics can be used as measures of an individual's cognitive ability and mental health in a single session or tracked throughout multiple sessions.

The disclosure provides methods of managing opioid therapy, particularly, for pain management. The methods comprise determining in a subject, for example, a subject who has received an opioid treatment, pupillary unrest in ambient light (PUAL). Low values of PUAL can be used to identify patients at risk for opioid side-effects, such as opioid-related respiratory depression (OIRD), and who warrant attention to prevent such side effects. Accordingly, the methods include monitoring the patients having low values of PUAL for signs of adverse side-effects and/or limiting or avoiding administration of opioids.

The disclosure provides methods of managing opioid therapy, particularly, for pain management. The methods comprise determining in a subject, for example, a subject who has received an opioid treatment, pupillary unrest in ambient light (PUAL). Low values of PUAL can be used to identify patients at risk for opioid side-effects, such as opioid-related respiratory depression (OIRD), and who warrant attention to prevent such side effects. Accordingly, the methods include monitoring the patients having low values of PUAL for signs of adverse side-effects and/or limiting or avoiding administration of opioids.

Provided herein are systems, devices and methods for monitoring the progression of, determining and/or assessing brain related conditions in a subject based on pupil light responses (PLRs) to focal central and peripheral chromatic light stimuli, in particular, by classifying the PLR based on one or more PLR parameter values, wherein the classifying allows monitoring the progression of, determining and/or assessing the brain related condition

A hand-held sized ocular and neurological screening device, system and method, the screening device comprising an eyepiece and a hand-held housing, the housing comprising a tubular stimulus chamber defining a light stimulus channel, wherein an illumination source is configured to provide light stimulus towards an opening through the light stimulus channel and an operational chamber comprising an infrared camera positioned outside the stimulus channel and inclined towards the opening, the infrared camera is configured to capture images of the pupils and eye movements through the opening without interfering with the light stimulus and a controller configured to receive the captured images from the infrared camera. The hand-held sized device can include a clip-on fixture for fixing the device onto a table, a desktop, or any portable ophthalmic apparatus.

A hand-held sized ocular and neurological screening device, system and method, the screening device comprising an eyepiece and a hand-held housing, the housing comprising a tubular stimulus chamber defining a light stimulus channel, wherein an illumination source is configured to provide light stimulus towards an opening through the light stimulus channel and an operational chamber comprising an infrared camera positioned outside the stimulus channel and inclined towards the opening, the infrared camera is configured to capture images of the pupils and eye movements through the opening without interfering with the light stimulus and a controller configured to receive the captured images from the infrared camera. The hand-held sized device can include a clip-on fixture for fixing the device onto a table, a desktop, or any portable ophthalmic apparatus.

A computer-implemented method is described. The method is be implemented by processors of an aircraft system. The method includes receiving images of an eye and a lighting configuration associated with a cockpit of an aircraft. The method further includes detecting a position of the eye within each of the images. The method further includes compensating for a pupillary light response of the eye based on the position of the eye within the image and the lighting configuration. By compensating for the pupillary light response, a fatigue level of the operator is estimated with reduced noise.

The disclosed ultrasound devices may include at least one ultrasound transmitter positioned and configured to transmit ultrasound signals toward a user's face to reflect off a facial feature of the user's face and at least one ultrasound receiver positioned and configured to receive and detect the ultrasound signals reflected off the facial feature. At least one processor may be configured to receive data from the at least one ultrasound receiver and to determine, based on the received data from the at least one ultrasound receiver, at least one of the following eye measurements: an interpupillary distance of the user; an eye relief; or a position of a head-mounted display relative to the facial feature of the user. Various other devices, systems, and methods are also disclosed.

An pupilometer device includes a stowable breath shield for preventing transmission of respiratory particles between patient and user.

An pupilometer device includes a stowable breath shield for preventing transmission of respiratory particles between patient and user.