Systems and methods are provided for measuring the mechanical properties of ocular tissue, such as the lens or corneal tissue, for diagnosis as well as treatment monitoring purposes. A laser locking feedback system is provided to achieve frequency accuracy and sensitivity that facilitates operations and diagnosis with great sensitivity and accuracy. Differential comparisons between eye tissue regions of a patient, either on the same eye or a fellow eye, can further facilitate early diagnosis and monitoring.

Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between −100 GHz and 100 GHz, excluding zero.

A slit lamp microscope of an aspect example includes a scanner and a data processor. The scanner is configured to scan an anterior segment of a subject's eye with slit light to collect a plurality of cross sectional images. The data processor is configured to generate opacity distribution information that represents a distribution of an opaque area in a crystalline lens, based on the plurality of cross sectional images collected by the scanner.

A target surface in an eye is located using a dual aiming beam apparatus that transmits a first aiming beam of light and a second aiming beam of light. An optics subsystem receives a laser beam from a laser source, the first aiming beam of light, and the second aiming beam of light, and directs the beams of light to be incident with the target surface and aligns the beams of light such that they intersect at a point corresponding to a focus of the laser beam. An imaging apparatus captures an image of the target surface including a first spot corresponding to the first aiming beam of light and a second spot corresponding to a second aiming beam of light. A separation between the spots indicates that the focus is away from the target surface, while overlapping spots indicate the focus is at or on the target surface.

A target surface in an eye is located using a dual aiming beam apparatus that transmits a first aiming beam of light and a second aiming beam of light. An optics subsystem receives a laser beam from a laser source, the first aiming beam of light, and the second aiming beam of light, and directs the beams of light to be incident with the target surface and aligns the beams of light such that they intersect at a point corresponding to a focus of the laser beam. An imaging apparatus captures an image of the target surface including a first spot corresponding to the first aiming beam of light and a second spot corresponding to a second aiming beam of light. A separation between the spots indicates that the focus is away from the target surface, while overlapping spots indicate the focus is at or on the target surface.

A system for and a method of analyzing a corneal lesion using an anterior segment image according to the present invention. The system includes: an image acquisition unit configured to acquire an anterior segment image from the eyeball of a subject, a feature extractor configured to extract feature information on a position and a cause of a lesion in the cornea from the anterior segment image by applying a convolution layer to the anterior segment image through machine learning on the basis of a database in which clinical information pre-acquired by analyzing positions and causes of lesions in the corneas of subjects is stored; and a result determination unit configured to identify a position of the cornea from the anterior segment image using the feature information and to analyze and determine the position and the cause of the lesion in the cornea from the position of the cornea.

A system for and a method of analyzing a corneal lesion using an anterior segment image according to the present invention. The system includes: an image acquisition unit configured to acquire an anterior segment image from the eyeball of a subject, a feature extractor configured to extract feature information on a position and a cause of a lesion in the cornea from the anterior segment image by applying a convolution layer to the anterior segment image through machine learning on the basis of a database in which clinical information pre-acquired by analyzing positions and causes of lesions in the corneas of subjects is stored; and a result determination unit configured to identify a position of the cornea from the anterior segment image using the feature information and to analyze and determine the position and the cause of the lesion in the cornea from the position of the cornea.

A method, a device, and a corresponding computer program product for calculating (optimizing) and producing a spectacle lens with the aid of a semi-personalized eye model. In one approach, the method includes providing personalized refraction data of at least one eye of the spectacles wearer; establishing a personalized eye model in which at least the parameters: shape of an anterior corneal surface of a model eye; a cornea-lens distance; parameters of the lens of the model eye; and lens-retina distance are established using personalized measured values for the eye of the spectacles wearer, and/or using standard values, and/or using the provided personalized refraction data, such that the model eye has the provided personalized refraction data, wherein at least the establishment of the lens-retina distance takes place via calculation.

A method, a device, and a corresponding computer program product for calculating (optimizing) and producing a spectacle lens with the aid of a semi-personalized eye model. In one approach, the method includes providing personalized refraction data of at least one eye of the spectacles wearer; establishing a personalized eye model in which at least the parameters: shape of an anterior corneal surface of a model eye; a cornea-lens distance; parameters of the lens of the model eye; and lens-retina distance are established using personalized measured values for the eye of the spectacles wearer, and/or using standard values, and/or using the provided personalized refraction data, such that the model eye has the provided personalized refraction data, wherein at least the establishment of the lens-retina distance takes place via calculation.

An ophthalmic portable laser slit lamp for ophthalmic examination and a method of eye inspection. The device comprises a portable housing containing an electronic timer circuit, a rechargeable battery, a laser module containing a laser emitting diode, a fixed focusing lens that sets the appropriate focal distance for the examination method and a line generator lens acting as a slit aperture. The laser beam aimed to the eye of the patient illuminates the eye with a very thin straight laser line at a fixed focal distance. The device also comprises a safety timer circuit that protects the patients eye against irradiation overload. The method of the invention allows the surgeon to detect surgical eye disorders at the operating room and helps to carry out a correct diagnosis in a much more precise and effective way than any light or laser spot device.