The ophthalmologic microscope has an illumination device for projecting light onto an eye to be observed and a microscope device with a camera to view the eye. The illumination device generates pulsed light. The light is pulsed at least at twice the frame rate of the camera to reduce flicker. The illumination device uses an array of micro-mirrors as spatial light modulator, and the mirrors are controlled for a balanced deflection over the frame cycles, which allows to increase the service life of the microscope.

The ophthalmologic microscope has an illumination device for projecting light onto an eye to be observed and a microscope device with a camera to view the eye. The illumination device generates pulsed light. The light is pulsed at least at twice the frame rate of the camera to reduce flicker. The illumination device uses an array of micro-mirrors as spatial light modulator, and the mirrors are controlled for a balanced deflection over the frame cycles, which allows to increase the service life of the microscope.

Peripheral retinal OCT can be used to generate peripheral retinal OCT images allowing for the peripheral retina to be viewed. A peripheral retinal vision system can determine that a set of fiducial markers is in a field-of-view of at least one camera and record positional data comprising a contact lens position and angle with respect to an OCT imaging system having OCT scanning mirrors in a first position. The system can determine whether a retinal layer is in an OCT scan captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position; and for an OCT scan having he retinal layer and being captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position, store that OCT scan.

Peripheral retinal OCT can be used to generate peripheral retinal OCT images allowing for the peripheral retina to be viewed. A peripheral retinal vision system can determine that a set of fiducial markers is in a field-of-view of at least one camera and record positional data comprising a contact lens position and angle with respect to an OCT imaging system having OCT scanning mirrors in a first position. The system can determine whether a retinal layer is in an OCT scan captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position; and for an OCT scan having he retinal layer and being captured while the set of fiducial markers is in the field-of-view of the at least one camera and the OCT scanning minors are in the first position, store that OCT scan.

The present disclosure is directed to systems and methods for measuring and analyzing pupillary psychosensory responses. An electronic device is configured to receive video data with at least two frames. The electronic device then locates one or more eye objects in the video data and determine pupil and iris sizes of the one or more eye objects. The electronic device determines the pupillary psychosensory responses of the one or more eye objects by tracking a ratio of pupil diameter to iris diameter throughout the video. Several metrics for the pupillary psychosensory responses can be determined (e.g., velocity of change of the ratio, peak to peak amplitude of the change in ratio over time, etc.). These metrics can be used as measures of an individual's cognitive ability and mental health in a single session or tracked throughout multiple sessions.

The disclosure provides methods of managing opioid therapy, particularly, for pain management. The methods comprise determining in a subject, for example, a subject who has received an opioid treatment, pupillary unrest in ambient light (PUAL). Low values of PUAL can be used to identify patients at risk for opioid side-effects, such as opioid-related respiratory depression (OIRD), and who warrant attention to prevent such side effects. Accordingly, the methods include monitoring the patients having low values of PUAL for signs of adverse side-effects and/or limiting or avoiding administration of opioids.

The disclosure provides methods of managing opioid therapy, particularly, for pain management. The methods comprise determining in a subject, for example, a subject who has received an opioid treatment, pupillary unrest in ambient light (PUAL). Low values of PUAL can be used to identify patients at risk for opioid side-effects, such as opioid-related respiratory depression (OIRD), and who warrant attention to prevent such side effects. Accordingly, the methods include monitoring the patients having low values of PUAL for signs of adverse side-effects and/or limiting or avoiding administration of opioids.

An ophthalmic information processing apparatus includes a specifying unit and an image deforming unit. The specifying unit is configured to specify a three-dimensional position of each pixel in a two-dimensional front image depicting a predetermined site of a subject's eye, based on OCT data obtained by performing optical coherence tomography on the predetermined site. The image deforming unit is configured to deform the two-dimensional front image, by changing position of at least one pixel in the two-dimensional front image based on the three-dimensional position, to generate a three-dimensional front image.

An ophthalmic information processing apparatus includes a specifying unit and an image deforming unit. The specifying unit is configured to specify a three-dimensional position of each pixel in a two-dimensional front image depicting a predetermined site of a subject's eye, based on OCT data obtained by performing optical coherence tomography on the predetermined site. The image deforming unit is configured to deform the two-dimensional front image, by changing position of at least one pixel in the two-dimensional front image based on the three-dimensional position, to generate a three-dimensional front image.

Aspects of the present disclosure provide techniques for quantitatively assessing tear-film dynamics associated with contact lenses. An example method includes projecting an image of one or more shapes on a tear film surface of the contact lens worn on the eye, capturing video data, comprising a plurality of image frames, of the one or more shapes projected on the tear film surface of the contact lens over a period of time, performing image segmentation on a plurality of reflection patterns included in the plurality of image frames, generating a plurality of maps of the tear film surface of the contact lens indicating changes to the tear film surface of the contact lens during the period of time, and outputting, based on the plurality of maps, one or more metrics quantifying the changes to the tear film surface of the contact lens over the period of time.