Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time.

A fast imaging apparatus and method for high resolution diffuse optical tomography with a line imaging and illumination system is disclosed. The method uses an algorithm comprising a convolution approximation of the forward heterogeneous scattering model that can be inverted to produce deeper than ever before structured beneath the surface. The method can detect reasonably accurate boundaries and relative depth of absorption variations up to a depth of approximately 8 mm below highly scattering medium such as skin.

An implementation cost of a line-scan optical coherence tomography (OCT) apparatus is reduced by miniaturizing a scanning mirror and using a light source with relaxed requirement in intensity uniformity. The mirror reflects a probe light beam to different parts of a sample for line-scanning the sample. A line-compressing lens compresses the probe light beam's cross-sectional length before the beam reaches the mirror, allowing the mirror to be miniaturized to reflect only the compressed beam. In generating a linear light beam that gives the probe light beam, a cascade of collimating lens, Powell lens and focusing lens generates the linear light beam from a raw light beam of a point source. A slit further filters the linear light beam to remove a peripheral portion thereof such that the linear light beam is substantially uniform in intensity even if an asymmetrical divergent light source is used.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced based on the acoustic wave. At least one portion of at least one second electro-magnetic radiation can be provided so as to determine information associated with at least one portion of the anatomical sample. In addition, the information based on data associated with the second electro-magnetic radiation can be analyzed. The first electro-magnetic radiation may include at least one first magnitude and at least one first frequency. The second electro-magnetic radiation can include at least one second magnitude and at least one second frequency. The data may relate to a first difference between the first and second magnitudes and/or a second difference between the first and second frequencies. The second difference may be approximately between −100 GHz and 100 GHz, excluding zero.

In one embodiment of the invention, a semiconductor optical amplifier (SOA) in a laser ring is chosen to provide low polarization-dependent gain (PDG) and a booster semiconductor optical amplifier, outside of the ring, is chosen to provide high polarization-dependent gain. The use of a semiconductor optical amplifier with low polarization-dependent gain nearly eliminates variations in the polarization state of the light at the output of the laser, but does not eliminate the intra-sweep variations in the polarization state at the output of the laser, which can degrade the performance of the SS-OCT system.

An integrated microtomography and optical imaging system includes a rotating table that supports an imaging object, an optical stage, and separate optical and microtomography imaging systems. The table rotates the imaging object about a vertical axis running therethrough to a plurality of different rotational positions during a combined microtomography and optical imaging process. The optical stage can be a trans-illumination, epi-illumination or bioluminescent stage. The optical imaging system includes a camera positioned vertically above the imaging object. The microtomography system includes an x-ray source positioned horizontally with respect to the imaging object. Optical and x-ray images are both obtained while the imaging object remains in place on the rotating table. The stage and table are included within an imaging chamber, and all components are included within a portable cabinet. Multiple imaging objects can be imaged simultaneously, and side mirrors can provide side views of the object to the overhead camera.

The present invention provides a breast computed tomography system in which the body motion and the pain of an examinee during capturing of images of the breast are reduced. The breast computed tomography system includes a gantry accommodating a light emitting unit that radiates light onto the breast. The gantry includes a gripper having a right gripping portion and a left gripping portion.

A photoacoustic image evaluation apparatus includes a processor configured to acquire a first photoacoustic image generated at a first point in time and a second photoacoustic image generated at a second point in time before the first point in time, the first and second photoacoustic images being photoacoustic images generated by detecting photoacoustic waves generated inside a subject, who has been subjected to blood vessel regeneration treatment, by emission of light into the subject; acquire a blood vessel regeneration index, which indicates a state of a blood vessel by the regeneration treatment, based on a difference between a blood vessel included in the first photoacoustic image and a blood vessel included in the second photoacoustic image; and display the blood vessel regeneration index on a display.

A system for imaging a target embedded in a scattering media includes: one or more light sources that are pulsed lights at one or more wavelengths in a range of visible to near-infrared; a detector, including a photodetector array with a time-gating function, configured to collect a scattered light after a gate start time; and a processor configured to determine an image of the target based on the scattered light.