An implantable neurostimulator-implemented method for managing tachyarrhythmias through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator, is configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers of a patient's cervical vagus nerve. Operating modes of the pulse generator are stored. A maintenance dose of the electrical therapeutic stimulation is delivered to the vagus nerve via the pulse generator to restore cardiac autonomic balance through continuously-cycling, intermittent and periodic electrical pulses. A restorative dose of the electrical therapeutic stimulation is delivered to prevent initiation of or disrupt tachyarrhythmia through periodic electrical pulses delivered at higher intensity than the maintenance dose. The patient's normative physiology is monitored via a physiological sensor, and upon sensing a condition indicative of tachyarrhythmia, is switched to delivering the restorative dose to the vagus nerve.

Means and methods for measuring pain and adapted for calculating the level of nociception during general anesthesia or sedation from data including electroencephalogram (EEG), facial electromyogram (EMG), heart rate variability (HRV) by electrocardiogram (ECG) and plethysmography by impedance cardiography (ICG). In a preferred embodiment of this invention the parameters derived from the EEG, the HRV, the plethysmographic curve and the analgetics concentrations are either combined into one index on a scale from 0 to 100, where a high number is associated with high probability of response to noxious stimuli, while a decreasing index is associated with decreasing probability of response to noxious stimuli. Zero (0) indicates extremely low probability of response to noxious stimuli. In an alternative embodiment, only features from the EEG and ECG will be used or only features from EEG, ECG and ICG, to define the fmal index.

The invention relates to a method for determining the physical and/or psychological state of a subject. The heart rate variability (HRV) of the subject is analyzed in the time domain, wherein at least one frequency distribution of interbeat intervals (IBI) which are detected in at least one examination time period (1) is examined in the analysis. In order to obtain particularly significant and quickly interpretable information for this purpose, the frequency distribution is examined for a multimodal distribution.

A system includes a controller coupled to one or more sensors. The controller receives sensor data indicative of biometric data an occupant of a vehicle seat from the sensors. The controller receives the sensor data and analyzes the data to provide biometric data associated with the occupant of the vehicle seat.

A heart-rate associated with a heartbeat signal is determined. A transform is selected based on the determined heart-rate associated with the heartbeat signal and a reference heart-rate associated with a dictionary of a sparse approximation model. The transform is selected independent of other factors associated with generation of the heartbeat signal. The selected transform is applied to the dictionary of the sparse approximation model, generating an adjusted dictionary of the sparse approximation model. Anomalous heartbeats in the heartbeat signal are detected using the adjusted dictionary of the sparse approximation model.

A method for detecting a position of a signal source in a living body includes: arranging three electrodes on a surface of the living body and alternately connecting a first external resistance and a second external resistance in parallel between the electrodes and a ground potential; measuring first voltages V.sub.i (i=1, 2, 3) generated at the respective electrodes when the first external resistance is connected in parallel between the electrodes and the ground potential, and second voltages V.sub.i (i=1, 2, 3) generated at the respective electrodes when the second external resistance is connected in parallel between the electrodes and the ground potential; and calculating three ratios V.sub.i/V′.sub.i (i=1, 2, 3) from the first and second voltages V.sub.i and V′.sub.i, and detecting the position of the signal source in the living body based on the three ratios V.sub.i/V′.sub.i (i=1, 2, 3).

Intracardiac electrograms are recorded using a multi-electrode catheter and respective annotations established. Within a time window a pattern comprising a monotonically increasing local activation time sequence from a set of electrograms from neighboring electrodes is detected. The set is reordered and displayed for the operator.

A cardiac medical system, such as an implantable cardioverter defibrillator (ICD) system, receives a cardiac electrical signal by and senses cardiac events when the signal crosses an R-wave sensing threshold. The system determines at least one sensed event parameter from the cardiac electrical signal for consecutive cardiac events sensed by the sensing circuit and compares the sensed event parameters to P-wave oversensing criteria. The system detects P-wave oversensing in response to the sensed event parameters meeting the P-wave oversensing criteria; and adjusts at least one of an R-wave sensing control parameter or a therapy delivery control parameter in response to detecting the P-wave oversensing.

A method of determining health and mortality includes obtaining a ventricular activation (RR) time series from a subject for multiple temporal intervals. The method also includes calculating a cardiac entropy in the RR time series over the temporal intervals using coefficient of sample entropy (COSEn). Additionally, the method includes comparing the cardiac entropy between the intervals to determine health and mortality. The absolute and relative changes in entropy over a patient's follow up period provide dynamic information regarding health and mortality risk. The determination of health and mortality can then be used to create a treatment plan for the subject.

The various embodiments of the present invention provide a system and method for a fully mobile, non-invasive, continuous system for monitoring the cardiovascular health of an individual. The system includes one or more wearable devices affixed on a user, coupled with an application running on a computing device smartphone/tablet, which is connected to a web server in a cloud, and performs various computations on the wearable device, or a smartphone/smartwatch, or the cloud, and provide the user or the concerned personnel with various insights about the general health of the user. The cardiovascular health monitoring system further enables the user to make online appointments, pay online for such appointments, share data with the concerned personnel in a secure manner, and obtain advice and prescriptions through audio/video/text channels.