There is provided a system for monitoring transpulmonary pressure of a mechanically ventilated individual, comprising: a feeding tube, at least one esophageal body, a pressure sensor, and a memory having stored thereon code for: computing an estimate of esophageal wall pressure according to pressure in the esophageal body when inflated and contacting the inner wall of the esophagus, computing the transpulmonary pressure of the mechanically ventilated target individual according to the esophageal wall pressure, periodically inflating and deflating the esophageal body for periodic monitoring of the transpulmonary pressure of the mechanically ventilated target patient while the feeding tube is in use, and computing instructions for adjustment of parameter(s) of a mechanical ventilator that automatically ventilates the target individual according to the computed transpulmonary pressure, wherein the instructions for adjustment of parameter(s) of the mechanical ventilator are computed while the feeding tube is in place without removal of the feeding tube.

An apparatus comprising at least two RIP measurement bands further comprises an electric power source arrangement, which excites simultaneously the at least two measurement bands with electric currents of different pseudo random variations, for making respiratory signals output by the at least two measurement bands unique. The apparatus also comprises a wireless transmitter arrangement, which transmits wirelessly respiratory information based on the respiratory signals output by the at least two measurement bands.

Disclosed herein are systems, non-transitory computer readable media, and methods to employ electrical impedance-based devices in clinical setting to perform hemodynamic assessments. A system may include a plurality of electrodes; and a controller coupled to the plurality of electrodes. The controller may receive a sequence of impedance datasets. The controller may generate a corresponding impedance image. The controller may determine a pre-maneuver hemodynamic measurement from a first region of interest (ROI) from at least one impedance image prior to a maneuver. The controller may determine a post-maneuver hemodynamic measurement from the first ROI from at least one impedance image following the maneuver. The controller may receive at least one parameter associated with the maneuver. The controller may determine a hemodynamic figure of merit based at least on the pre-maneuver hemodynamic measurement, the post-maneuver hemodynamic measurement, and the at least one parameter associated with the maneuver.

In the present invention, a system and associated method is provided for monitoring vital parameters of a patient. The monitoring system includes sensors disposed on the patient and operably connected to a monitor. The parameters that are sensed by the sensors are transmitted to the monitor and compared with alarm thresholds and operational criteria stored within the monitor. When an alarm condition is sensed by the system, the system can actively solicit patient assistance in the confirmation of the alarm condition based on a set of reactive inputs stored within the system to enable medical personnel to appropriately respond to clinically relevant sensed alarm condition(s).

An apparatus comprises a respiration sensing circuit configured for coupling electrically to a plurality of electrodes and for sensing a respiration signal representative of respiration of a subject; a signal processing circuit electrically coupled to the respiration sensing circuit and configured to extract a respiration parameter from a sensed respiration signal and determine a signal performance metric for the sensed respiration signal using the respiration parameter; and a control circuit. The control circuit is configured to: initiate sensing of a plurality of respiration signals using different electrode combinations of the plurality of electrodes and determining of the signal performance metric for the sensed respiration signals; and enable an electrode combination from the plurality of electrodes and for use in monitoring respiration of the subject according to the signal performance metric.

A stimulation system for delivery of a stimulation signal to a hypoglossal nerve of a patient to treat obstructive sleep apnea. The stimulation system includes an implantable receiver coil configured to be implanted under a mandible of the patient; a nerve electrode coupled to the implantable receiver coil, the nerve electrode configured to deliver the stimulation signal to the hypoglossal nerve of the patient; an external pulse generator configured to generate the stimulation signal; and an external transmitter coil configured to wirelessly transmit the stimulation signal from the external pulse generator to the implantable receiver coil, the external transmitter coil being carried by an adhesive patch configured to be placed on the skin adjacent the implantable receiver coil under the mandible of the patient.

The present disclose generally relates to systems and methods for active titration of one or more cranial or peripheral nerve stimulators to treat obstructive sleep apnea. The active titration can be accomplished in an automated fashion by a closed-loop process. The closed-loop process can be executed by a computing device that includes a non-transitory memory storing instructions and a processor to execute the instructions to perform operations. The operations can include defining initial parameters for the one or more cranial or peripheral nerve stimulators for a patient; receiving sensor data from sensors associated with the patient based on a stimulation with the one or more cranial or peripheral stimulators programmed according to the initial parameters; and adjusting the initial parameters based on the sensor data.

An implantable monitoring device includes first sensors to measure state information of one or both of a posture and an activity of a user and second sensors to measure bioinformation of two or more of an electrocardiogram (ECG) of a heart of the user, a pulmonary impedance of a lung of the user, a movement of the heart, a movement of a thorax including the lung, and a respiratory quotient (RQ) of the lung, two electrodes to detect bioinformation to measure one or both of the ECG and the pulmonary impedance, an analog circuit to process the detected bioinformation to measure the one or both of the ECG and the pulmonary impedance, and a processor to monitor an abnormal state of the heart and the lung of the user based on the state information and the bioinformation.

A measurement unit for measuring a bio-impedance of a body, the measurement unit comprising a current generator circuit, a readout circuit, and a baseline cancellation current circuit, wherein the current generator circuit is configured to amplify a reference current to form a measurement current to be driven through a body to generate a measurement voltage representing the bio-impedance; wherein the readout circuit comprises a Instrumentation amplifier (IA) which has a transconductance stage and a transimpedance stage, wherein the IA is configured to: produce a first current in the transconductance stage, the first current being proportional to the measurement voltage, receive a second current from the baseline cancellation current circuit, produce an output voltage in the transimpedance stage, the output voltage being proportional to a difference between the first current and the second current and representative of the measured bio-impedance; wherein the baseline cancellation current circuit is configured to amplify the reference current by a factor to form the second current and deliver it to the IA, wherein the factor is such that that the absolute value of the difference between the first and the second current is below a threshold such that a baseline of the first current is cancelled by the second current.

A process adjusts a ventilation parameter (40) for a ventilation process (90) of a patient (110), which is carried out by a ventilator (20). Electrical impedance tomographic (EIT) data (70) of the lungs (111) of the patient (110), concerning the ventilation process (90), are collected by an EIT device (30). An adjusting device (1), adjusting a ventilation parameter (40) for the ventilation process (90), has an analysis unit (2) with a memory (3), a data input unit (5) data-communicatingly connected to the analysis unit (2) for receiving data and a data output unit (7) data-communicatingly connected to the analysis unit (2) for outputting data. A medical system (100), includes a ventilator (20), an EIT device (30) as well as the adjusting device (1) for adjusting a ventilation parameter (40) for the ventilation process (90) of a patient (100).