An electrode measuring the presence of an analyte is described as one embodiment. The electrode includes a working conductor with an electrode reactive surface and a first reactive chemistry that is responsive to the analyte. The electrode further includes a first transport material that enables flux of the first analyte to the first reactive chemistry and a second transport material that supplies a reactant to the first reactive chemistry. Wherein the first reactive chemistry does not contact the electrode reactive surface while at least partially shadowing a portion of the electrode reactive surface.

Described herein are devices and methods for continuous real time monitoring of kidney function. In various embodiments, a urine analysis device collects sensor data describing one or more properties of urine. The urine analysis device may be integrated with a catheter system to continuously generate sensor data in real time as the urine is collected by the catheter system. Sensor data collected by the urine analysis device may be analyzed by physicians to detect changes in a patients kidney function. If necessary, based on the sensor data, physicians may perform an intervention to improve a patients kidney function.

A non-invasive detection method and device, and a wearable apparatus for tissue element are provided. The method includes: acquiring, for a detected site of a detected object, a second light intensity measurement value for each predetermined wavelength of at least one predetermined wavelength at a measurement distance, and/or a second light intensity reference value for each predetermined wavelength of at least one predetermined wavelength at a reference distance, wherein the measurement distance is a source-detection distance corresponding to the first light intensity measurement value, and the reference distance is a source-detection distance corresponding to the first light intensity reference value; and determining a concentration of a tissue element to be detected according to the second light intensity measurement value of each predetermined wavelength and/or the second light intensity reference value for each predetermined wavelength.

A system and method is provided for monitoring a biological substance in a bodily orifice. The system includes a wearable device configured to be worn in a bodily orifice. A biosensor is carried by the wearable device and is constructed and arranged to obtain raw data regarding a biological substance in the orifice. The biosensor includes a processor circuit to provide processed data from the raw data, and a transmitter to wirelessly transmit the processed data to a second device.

The present disclosure relates to optical methods and devices based on pulsate behavior of blood and optical absorption spectroscopy to measure the level of water and/or other substances or compounds, such as an alcohol or lipid, in the blood and the tissues surrounding blood vessels and arteries.

The present invention relates to an electrocardiogram measurement apparatus (measurement sensor) which can be used in combination with a smartphone by an individual. The electrocardiogram measurement apparatus according to the present invention comprises: two amplifiers for receiving electrocardiogram signals from a first electrode and a second electrode; one electrode driving unit; a third electrode for receiving an output of the electrode driving unit; an A/D converter connected to an output terminal of each of the two amplifiers and converting analog signals into digital signals; a microcontroller for receiving the digital signals from the A/D converter; and a communication means for transmitting the digital signal, wherein: the microcontroller is supplied with power from a battery; the microcontroller controls the A/D converter and the communication means; and each of the two amplifiers amplifies one electrocardiogram signal so as to simultaneously measure two electrocardiogram signals.

Embodiments of the presently-disclosed subject matter include methods and systems for measuring a level of a neurotransmitter in a subject. Embodiments of the present methods comprise displaying a fixation point, a reward target, and a non-reward target, and measuring one or more saccade movement parameters for reward saccades and non-reward saccades. The saccade movement parameters can include velocity, amplitude, reaction time, or a combination thereof. The present methods can further include determining a reward modulation of the subject, the reward modulation being equal to a difference between the reward and the non-reward values for a respective saccade movement parameter. Some embodiments further include identifying the subject as including a deficiency of the neurotransmitter if there is a statistically measurable difference between the reward modulation of the subject and a reference reward modulation and/or if the non-reward and the reward saccade movement parameters are statistically equivalent.

The present disclosure provides an operating method of a dopamine transporter check system, and the operation method includes steps as follows. A scan image of a subject's brain is obtained from a scan machine, and the scan image is a three-dimensional image. The scan image is aligned to a standard brain space to obtain a standardized scan image. Intensity normalization is performed on the standardized scan image. The standardized scan image after the intensity normalization is converted into a two-dimensional image. A plurality of image data are got from at least one region of interest in the two-dimensional image, and the at least one region of interest includes a left caudate, a left putamen, a right caudate and a right putamen. A dopamine neuron loss degree measurement and evaluation model based on the image data is established through a transfer learning.

Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

The concentration of substance in blood is measured non-invasively, with high accuracy and with simple configuration. Laser light 100 generated by a light source 10 is locally irradiated on the body epithelium F of a subject, and the resulting diffused reflected light 200 is detected by a light detector 40. The laser light 100 has a wavelength of 9.26 μm. The laser light 100 is generated by converting and amplifying pulsed excitation light 101 from an excitation light source 11 to a long wavelength. A plate-shaped window 300 that is transparent to mid-infrared light is brought in close contact with the body epithelium F. The glucose concentration in interstitial fluid can be calculated using normalized light intensity calculated from a signal ratio of signals from a monitoring light detector 16 and light detector 40.