The present invention provides a method and means useful for recovering an extracellular vesicle. More specifically, the present invention provides the following (I) and (II).

(I) A method for recovering extracellular vesicle, the method including: (1) mixing whole blood with a nonionic surfactant and a chelating agent to give a mixture solution containing the extracellular vesicle, the nonionic surfactant and the chelating agent; and (2) separating the extracellular vesicle from the mixture solution.

(II) A blood collection vessel containing a nonionic surfactant and a chelating agent.

A hand-held applicator (10) for collecting, mixing, diluting and discharging a sample liquid, comprising a main body (20) having an inlet-aperture (24), an outlet-aperture (26) and a chamber (22) for storing a liquid solution, wherein the chamber is connected to the inlet-aperture and the outlet-aperture, a lid (12) for covering the inlet-aperture and a tube (40), moveably supported in the inlet-aperture when the lid is covering the upper portion of the main body, wherein the tube (40) is moveable between a predetermined position outside the chamber and a position, in which the tube is at least partly located in the chamber.

The present disclosure relates to a capillary blood collecting device which includes a fixing device including an accommodating cavity for accommodating a blood collection finger and a squeezing member for squeezing blood to a fingertip site. The capillary blood collecting device is configured to detachably accommodate at least one skin puncture part on a blood collection side of the finger, and the skin puncture part includes a blood lancet that may be driven to puncture the blood collection finger, such that a sufficient amount of capillary blood quickly flows out from the capillary blood converged at the fingertip under the action of blood lancet.

Improvements in and relating to blood sampling devices A blood sampling device includes a housing and a lancet supporting a lancet needle or tip, the lancet and needle being urged or urgeable in a pricking direction. A trigger mechanism is moveable to a fire position for releasing the lancet to travel in the pricking direction. A removable safety cap initially covers the lancet needle. The lancet has an initial position in which movement of the trigger mechanism to its fire position is blocked and an intermediate position in which the trigger mechanism may be moved to its fire position. The intermediate position is obtainable only on removal of the safety cap.

Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member.

An article (100) comprising at least one microneedle (160) is provided. The article comprises a first side (112) and a second side (114) opposite the first side. The first side comprises a central cavity portion (120) and a platform portion (130), with at least one microneedle extending therefrom, wherein the platform portion is not coplanar with the central cavity portion. The platform portion substantially surrounds the central cavity portion. The at least one microneedle comprises a body comprising an outer surface (163); a base segment (166) having a base (162) and a first shape; a tip segment (168) having a tip and a second shape, wherein the second shape is distinct from the first shape; a transition plane (167) that delineates the base segment and the tip segment; and a central axis (180). Methods of using the article are also provided.

The present invention generally relates to collecting, determining and/or transmitting information associated with the process of receiving bodily fluid through a device opening and/or delivering substances to a subject. In one aspect, the device includes an information collecting portion and a fluid receiving portion. In another aspect, the two portions are constructed and designed to attach to one another. In one embodiment, actuation of one of the portions causes the other portion to actuate. Methods of time keeping and information transmission are also discussed.

The present disclosure relates generally to devices, systems, and methods for diagnosis and treatment via laser-treated skin and, more particularly, to devices, systems, and methods for inducing leakage or rupture of one or more blood vessels comprising the dermis for various diagnostic and therapeutic applications. Other aspects of the present disclosure can include methods for detecting one or more target analytes in a dermis of a subject, methods for facilitating skin-to-blood delivery of agent in a subject, and methods for collecting a fluid sample from the dermis of a subject.

The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.

Transdermal microneedles continuous monitoring system is provided. The continuous system monitoring includes a substrate, a microneedle unit, a signal processing unit and a power supply unit. The microneedle unit at least comprises a first microneedle set used as a working electrode and a second microneedle set used as a reference electrode, the first and second microneedle sets arranging on the substrate. Each microneedle set comprises at least a microneedle. The first microneedle set comprises at least a sheet having a through hole on which a barbule forms at the edge. One of the sheets provides the through hole from which the barbules at the edge of the other sheets go through, and the barbules are disposed separately.