A biological fluid collection device that includes a housing and a cartridge that is removably receivable within a portion of the housing is disclosed. The biological fluid collection device of the present disclosure allows for collection of capillary blood from a finger stick and provides a closed system that reduces the exposure of a blood sample. In one embodiment, a cartridge of the present disclosure also provides fast mixing of a blood sample with a sample stabilizer. In another embodiment, a cartridge of the present disclosure provides automatic plasma separation of the blood sample. Advantageously, once the cartridge is filled with a sample aid removed from the housing, the cartridge can be used for a variety of important purposes.

Provided are systems and methods for reducing pain during an injection or an insertion of an object into the skin of a subject.

The present disclosure provides a lancing device that includes a lancet for piercing a user's skin and a lancing device body to drive the lancet. An actuator included in the lancing device body can drive the lancet to perform a linear reciprocating motion multiple times upon a single activation. Accordingly, the lancet may pierce the user's skin multiple times upon a single activation.

A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet along a path into the tissue site, and a manual switch for a user interface input.

Skin stimulus arrangements are described for creating a stimulus in the skin in the vicinity of a treatment or wound site to alleviate the perception of pain. First and second textured surfaces are provided for making contact with the skin, with the surfaces being moved to create a stimulus which alleviates the perception of pain. The movement may be linear, rotary or a combination of both, and just a single textured surface may be provided.

A vacuum assisted lancing system for blood extraction can include a tubular body having a vacuum chamber, a lancing mechanism configured to removably couple with a lance, a vacuum mechanism including a piston slideably coupled within the body, a release mechanism for selectively holding the vacuum mechanism in an energized state, and an opening for allowing fluid communication between the vacuum chamber and an atmosphere surrounding the vacuum chamber. The system can include structure for selectively commencing dissipation of the vacuum and a fixed or adjustable depth controller. A method of manipulating a surface for blood extraction can include coupling the lancing system to the surface, blocking the opening, creating a vacuum, moving the lance coupler from a first position distal from the surface to a second position proximal to the surface, maintaining the vacuum for a period of time, and commencing dissipation of the vacuum by unblocking the opening.

A device for giving injections has a housing having a lower surface and an upper surface with a passage through the housing extending between the upper and lower surfaces. A DC motor with an eccentric fixed to the motor is located inside the housing to vibrate the housing. At least one tubular insert is located in the passage through the housing and is fixed to the housing. A syringe receiver is located inside and fixed to the at least one tubular insert. The syringe receiver contains a foam insert defining a space for receiving a syringe. The foam insert is a polyurethane foam characterized by an indentation force deflection of about 25% at 127 N and about 65% at 256N. The foam insert isolates a syringe from the vibrating of the housing.

A vibrating needle device of the invention includes a needle including a main body portion extending in a direction of a first axis and having a groove formed in an outer circumferential surface over an entire circumference in a circumferential direction around the first axis. A tip portion is provided at one end of the main body portion and tapered in a direction away from the main body portion in the direction of the first axis. A vibrating unit is configured to vibrate the needle along the direction of the first axis and a direction of a second axis that intersects with the direction of the first axis.

The various embodiments disclosed herein are devices that deliver electrical stimulation and/or vibration stimulation to the surface of skin in proximity to insulin injections and/or glucose testing in order to decrease or eliminate the pain of these procedures.

A lancing device with an ejector that is movably retained with a housing in proximity to a lancet and is selectively movable between a home position, a first eject position, an intermediate position defined by contact of the ejector with the lancet, and a second eject position. The ejector is rotatable to move from the home to first eject position and is linearly translatable to move between the first and second eject positions. The ejector includes an arm that extends within the housing and engages the lancet, an exterior portion that is actuated by a user, and a post extending therebetween. The post extends through a slot in the housing which limits the linear movement and direction of the ejector. Upon rotation of the ejector, the arm extends through an opening at the rear of the carriage holding the lancet to permit access to the lancet.