Device for the in-vivo and/or in-vitro enrichment of target structures in a sample liquid, including at least one functional portion, which is provided with receptors for enriching the target structures. In order to improve the enrichment of the target structures in the sample liquid, it is provided according to the invention that the functional portion has a helical shape, which is produced by twisting a symmetrical starting cross section about a twisting axis. The invention likewise discloses a method for producing this device.

Exemplary embodiments provide automatic injection devices, housing components for automatic injection devices and methods for fabricating the same. An exemplary housing of an automatic injection device may be overmolded with one or more gripping surfaces to facilitate gripping and manipulation of the automatic injection device by a user when performing an injection. In an exemplary embodiment, an overmolded left gripping surface may extend along a left side of the housing and an overmolded right gripping surface may extend along a right side of the housing opposite to the left side.

A flow restriction device may include a proximal housing including an internal fluid channel, a distal housing including an internal fluid channel, and an intermediate housing interposed between the proximal and distal housings. The intermediate housing may include an internal chamber, and a slider reciprocally disposed in the internal chamber. The slider may include an internal fluid channel and a seal overlaying an outer surface of slider excluding the fluid channel, and may be reciprocally movable between (i) a first position where the internal fluid channel of the slider is axially aligned with the internal fluid channels of the proximal and distal housings to allow a fluid to flow therethrough, and (ii) a second position where the internal fluid channel of the slider is not aligned with the internal fluid channels of the proximal and distal housings and the seal blocks fluid connection between the proximal and distal housings.

The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.

Peripheral intravenous catheter assemblies with capabilities for both blood sampling and catheterization can have a blood collection holder with a needle hub attached to a catheter hub. The combination catheter assembly and blood sampling holder can be called a catheter and holder assembly. Blood sampling can be done directly through the needle and the blood collection holder after cannulation. After blood sampling, the blood collection holder and the needle can be removed, leaving the catheter hub with the patient for IV infusion. The catheter hub can be a straight catheter hub or can include a side fluid port for use in as an integrated IVC.

This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.

The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.

A flow restriction device may include a male luer connector portion, a female luer connector portion disposed proximally to the male luer connector portion, and a body portion extending between the male and female luer portions, and integrally formed with the male and female luer portions to form a single monolithic piece. The male luer connector portion may have an internal surface defining a lumen thereof, and the female luer connector portion may have an internal surface defining a lumen fluidly connected to the lumen of the male luer connector portion. The body portion may have a recess extending longitudinally therethrough and fluidly communicated with the lumens of the male luer portion and the female luer portion. The recess may define a micro-channel along which fluid flows from the male luer connector portion into the fluid collection device via the female luer connector portion.

Exemplary embodiments provide automatic injection devices, housing components for automatic injection devices and methods for fabricating the same. An exemplary housing of an automatic injection device may be overmolded with one or more gripping surfaces to facilitate gripping and manipulation of the automatic injection device by a user when performing an injection. In an exemplary embodiment, an overmolded left gripping surface may extend along a left side of the housing and an overmolded right gripping surface may extend along a right side of the housing opposite to the left side.

Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.