A method of assessing or monitoring the normal skin sympathetic nerve activity in a living subject, the subject having a skin, comprises assessing or measuring electrodermal activity, wherein the electrodermal activity is skin conductance, galvanic skin response, electrodermal response, psychogalvanic reflex, skin conductance response, sympathetic skin response or skin conductance level. Skin conductance may be assessed by calculating skin conductance fluctuation peaks per time unit, and when the skin conductance fluctuations peaks are above a certain predefined value, the normal skin sympathetic nerve activity is defined in an analyzing window with a length of about 15 to 60 seconds, the normal skin sympathetic nerve activity is assessed as being obtained or successful. Alternatively, the skin conductance may be assessed by calculating rise time of the mean skin conductance level, the area under the skin conductance fluctuations or the size of the amplitude of the skin conductance fluctuation.

An electronic system for bioimpedance signal acquisition, comprises: a current signal injection module configured for generating a current signal to be applied to a subject; a bioimpedance signal measurement module configured for measuring a bioimpedance signal based on a voltage generated by the current signal; a data quality detection module configured for detecting an AC or a DC level of the measured bioimpedance signal and detecting whether the AC or DC level is within or outside an AC reference value range and a DC reference value range, respectively; and a signal adaptation module configured for modifying at least one parameter of the current signal injection module or the bioimpedance signal measurement module based on said detection of the AC or DC level in relation to the AC reference value range and the DC reference value range, respectively.

The embodiments include an apparatus used in combination with a computer for sensing biopotentials. The apparatus includes a catheter in which there is a plurality of sensing electrodes, a corresponding plurality of local amplifiers, each coupled to one of the plurality of sensing electrodes, a data, control and power circuit coupled to the plurality of local amplifiers, and a photonic device bidirectionally communicating an electrical signal with the data, control and power circuit. An optical fiber optically communicated with the photonic device. The photonic device bidirectionally communicates an optical signal with the optical fiber. An optical interface device provides optical power to the optical fiber and thence to the photonic device and receives optical signals through the optical fiber from the photonic device. The optical interface device bidirectionally communicates an electrical data, control and power signal to the computer.

There is provided herein a stress reducing and/or mindfulness inducing apparatus including: a substantially spherically shaped body “huggable” by two hands of a user; at least a first and a second pair of indentations located on an outer surface of said body, wherein each of the first and the second pair of indentations is suitable for placing corresponding index, middle and ring fingers from each hand of the user, wherein each of the first and the second pair of indentations comprises one or more sensors, wherein the one or more sensors are configured to sense one or more parameters associated with the user's stress and/or mindfulness state, wherein the sensors are the same or different from each other; and an indicator having at least two modes of operation, the indicator is configured to provide the user with an indication regarding his/her stress and/or mindfulness state.

A measuring apparatus is configured to be connected to an electrode to measure biopotential. The measuring apparatus has an input box to which the electrode is connected. The input box has a tubular elastic member configured to hold a cap to be mounted on the electrode, and an insertion portion configured such that the elastic member is insertable into the insertion portion. The elastic member has an entrance having a first inner diameter and a contracted portion having a second inner diameter smaller than the first inner diameter.

Described herein are functionalized garments that can be worn on the torso of a subject and can be configured with varying zones or areas of compressions and can provide increased signal-to-noise ratios and reduced motion artifacts in areas while allowing a substantially unimpeded freedom of motion.

A current sensor may take measurements of electrical currents that flow between two limbs of a patient through at least a portion of the patient's torso. The current measurements may be taken during a single diagnostic session while the patient holds a ground electrode in a hand of one limb and a probe electrode is sequentially placed at different locations on the distal portions of other limbs. Each of the measurement locations may be an acupuncture point. An electrical current state for the diagnostic session may be calculated. This state may consist of current ranges for one or more electrical currents that are measured during the session. A lookup table may be employed to determine one or more medical conditions that are indicated by the current state. Alternatively, a trained machine learning model may predict, based on the measured currents, one or more medical conditions.

In one embodiment, a method to differentiate between causes of noise in an electrocardiogram (ECG) signal. The method connecting to at least one sensing electrode and obtaining the ECG signal from the at least one sensing electrode. The method also includes detecting noise on the ECG signal and detecting ancillary conditions. The method also includes associating the noise on the ECG signal with at least one of the ancillary conditions and providing an actionable indication to a patient associated with the noise on the ECG signal.

A biopotential can be measured with high accuracy without the electrodes coming into direct contact with the skin and without being affected by any motion artifact. The present invention comprises a first lead which detects a biopotential containing noise components, a second lead which is electrically isolated from the first lead and detects noise components, and a differential amplifier circuit which is input with a first signal output from the first lead and a second signal output from the second lead, and which amplifies and outputs a difference between the first signal and the second signal, wherein a value of an input impedance on the second signal side of the differential amplifier circuit is set so that the noise components detected from the second lead will have a frequency that is higher than a frequency spectrum of the biopotential.

A method and system are described for, based upon a plurality of previously-acquired directional LFP signals measured in a plurality of different directions at a directional sensor lead located in a predetermined region of a patient's brain, determining optimised patient-specific programming parameters for programming a directional stimulation lead with parameters for stimulating the said region. The method comprises a first step of determining, over at least one predetermined frequency range, a power-frequency variation curve of each of the directional LFP signals, a second step of identifying frequency peaks in the power-frequency variation curves, a third step of detecting one of the identified frequency peaks at which a maximum difference in signal power between the directional LFP signals occurs, and a fourth step of calculating a plurality of directional stimulation weighting factors on the basis of the relative signal powers of the directional LFP signals at the detected frequency peak.