A sterile packaging assembly for transporting interventional devices to a robotic surgery site includes a sterile barrier having a hub support portion and configured to enclose a sterile volume; and at least a first interventional device within the sterile volume. The first interventional device includes a hub and an elongate flexible body. The hub includes at least one magnet and at least one roller configured to roll on the hub support portion of the sterile barrier.

Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

A method of controlling operation of a neurostimulation device comprises receiving, by the neurostimulation device, an indication of a physiological search area of a subject for delivering electrical neurostimulation and a prioritized search list of neurostimulation parameters for neurostimulation therapy delivered to the search area; delivering the neurostimulation therapy to the search area and varying the neurostimulation parameters according to the parameter priority, wherein a highest priority parameter is varied first while lower priority parameters are held constant; determining the optimum value of the highest priority parameter; delivering neurostimulation to the search area using the determined optimum value of the highest priority parameter and varying one or more lower priority parameters according to the parameter priority; and determining optimum lower priority parameters for the neurostimulation.

A method of controlling operation of a neurostimulation device comprises receiving, by the neurostimulation device, an indication of a physiological search area of a subject for delivering electrical neurostimulation and a prioritized search list of neurostimulation parameters for neurostimulation therapy delivered to the search area; delivering the neurostimulation therapy to the search area and varying the neurostimulation parameters according to the parameter priority, wherein a highest priority parameter is varied first while lower priority parameters are held constant; determining the optimum value of the highest priority parameter; delivering neurostimulation to the search area using the determined optimum value of the highest priority parameter and varying one or more lower priority parameters according to the parameter priority; and determining optimum lower priority parameters for the neurostimulation.

Flexible implant for electrically recording or stimulating a nerve structure, said flexible implant comprising: a first layer of electrically insulating diamond; an electrode of electrically conductive doped diamond, in contact with the first layer of electrically insulating diamond; an electrically conductive layer in contact with the electrode and the first layer, so as to define a conductive track for the electrode; and a second layer of electrically insulating diamond, at least in contact with the electrically conductive layer and a remaining portion of the first layer, all of the above arranged such that: electrically insulating diamond/electrically conductive doped diamond sealing is provided at the electrode (3) by resumption of epitaxial growth; and the electrically conductive layer is encapsulated by the electrode (3), the first layer and the second layer, at the electrode and over the entirety of the remaining surface thereof except over an area defining an electrical contact. The implant has two faces, namely: a front face comprising one of the two layers of electrically insulating diamond, open locally, providing access to the electrode and the area defining an electrical contact; and a rear face comprising the other of the two layers of electrically insulating diamond.

Flexible implant for electrically recording or stimulating a nerve structure, said flexible implant comprising: a first layer of electrically insulating diamond; an electrode of electrically conductive doped diamond, in contact with the first layer of electrically insulating diamond; an electrically conductive layer in contact with the electrode and the first layer, so as to define a conductive track for the electrode; and a second layer of electrically insulating diamond, at least in contact with the electrically conductive layer and a remaining portion of the first layer, all of the above arranged such that: electrically insulating diamond/electrically conductive doped diamond sealing is provided at the electrode (3) by resumption of epitaxial growth; and the electrically conductive layer is encapsulated by the electrode (3), the first layer and the second layer, at the electrode and over the entirety of the remaining surface thereof except over an area defining an electrical contact. The implant has two faces, namely: a front face comprising one of the two layers of electrically insulating diamond, open locally, providing access to the electrode and the area defining an electrical contact; and a rear face comprising the other of the two layers of electrically insulating diamond.

The present application relates to a spectro-temporal modulation (STM) detection test unit comprising a stimulus generation unit comprising at least one output unit configured to present a first probe stimulus to one ear of a user and to present a second probe stimulus to another ear of the user, an analysis unit configured to determine, in response to presenting the probe stimuli, a modulation-detection threshold of the user, where the stimulus generation unit being configured to generate each of the first probe stimulus and the second probe stimulus based on a carrier signal with a spectro-temporal modulation added, and where the spectro-temporal modulation of the first probe stimulus is different from the spectro-temporal modulation of the second probe stimulus. The present application further relates to a system and a method.

The present application relates to a spectro-temporal modulation (STM) detection test unit comprising a stimulus generation unit comprising at least one output unit configured to present a first probe stimulus to one ear of a user and to present a second probe stimulus to another ear of the user, an analysis unit configured to determine, in response to presenting the probe stimuli, a modulation-detection threshold of the user, where the stimulus generation unit being configured to generate each of the first probe stimulus and the second probe stimulus based on a carrier signal with a spectro-temporal modulation added, and where the spectro-temporal modulation of the first probe stimulus is different from the spectro-temporal modulation of the second probe stimulus. The present application further relates to a system and a method.

Disclosed is a frequency-selective signal damper including: a viscous polymer exhibiting non-Newtonian fluid behavior; and hydrogel exhibiting sol-gel phase transition. The viscous polymer exhibits shear thinning in a damping region or a noise region, and the hydrogel has a sol phase in the damping region or the noise region. The viscous polymer is gelatin, and the hydrogel is chitosan.

Disclosed is a frequency-selective signal damper including: a viscous polymer exhibiting non-Newtonian fluid behavior; and hydrogel exhibiting sol-gel phase transition. The viscous polymer exhibits shear thinning in a damping region or a noise region, and the hydrogel has a sol phase in the damping region or the noise region. The viscous polymer is gelatin, and the hydrogel is chitosan.