A catheter includes an insertion tube, a flexible substrate and one or more electrical devices. The insertion tube is configured for insertion into a patient body. The flexible substrate is configured to wrap around a distal end of the insertion tube and includes electrical interconnections. The electrical devices are coupled to the flexible substrate and are connected to the electrical interconnections.

A catheter has a body including a proximal region, a neck region, and a distal region. A shaping wire is disposed within the distal region to predispose it into at least a partial loop, which may have a fixed or variable radius of curvature. The shaping wire includes a distal portion having a circular transverse cross-sectional shape and a proximal portion having a non-circular (e.g., rectangular) transverse cross-sectional shape. The proximal portion of the shaping wire can have a width-to-thickness ratio of at least about 4, such as about 4.67. A transition portion can promote a gradual transition from the circular to the non-circular transverse cross-sectional shape, for example by increasing a width of the shaping wire by about 0.001″ and/or by decreasing a thickness of the shaping wire by about 0.001″ for every about 0.004″ in length through the transition portion.

A catheter has a body including a proximal region, a neck region, and a distal region. A shaping wire is disposed within the distal region to predispose it into at least a partial loop, which may have a fixed or variable radius of curvature. The shaping wire includes a distal portion having a circular transverse cross-sectional shape and a proximal portion having a non-circular (e.g., rectangular) transverse cross-sectional shape. The proximal portion of the shaping wire can have a width-to-thickness ratio of at least about 4, such as about 4.67. A transition portion can promote a gradual transition from the circular to the non-circular transverse cross-sectional shape, for example by increasing a width of the shaping wire by about 0.001″ and/or by decreasing a thickness of the shaping wire by about 0.001″ for every about 0.004″ in length through the transition portion.

The signal quality of an electrophysiological signal can be determined from information regarding proximal stability of an electrophysiology catheter at the time the signal is acquired and temporal stability of the electrophysiological signal. The proximal stability information can include a distance between the electrophysiology catheter and an anatomical surface, a velocity of the electrophysiology catheter, and/or contact force between the electrophysiology catheter and the anatomical surface. Graphical representations of signal quality scores can be output to a display in order to enable visualization thereof by a practitioner.

The signal quality of an electrophysiological signal can be determined from information regarding proximal stability of an electrophysiology catheter at the time the signal is acquired and temporal stability of the electrophysiological signal. The proximal stability information can include a distance between the electrophysiology catheter and an anatomical surface, a velocity of the electrophysiology catheter, and/or contact force between the electrophysiology catheter and the anatomical surface. Graphical representations of signal quality scores can be output to a display in order to enable visualization thereof by a practitioner.

A method includes assigning, to first voxels in a model of tissue of a chamber of a heart, respective first values of a parameter at respective locations on the tissue, the first voxels representing the locations, respectively. Some of the locations are on an endocardial surface of the tissue, and others of the locations are on an epicardial surface of the tissue. The method further includes assigning respective second values to second voxels in the model, a subset of which represent a portion of the tissue between the endocardial surface and the epicardial surface, by interpolating the first values. Other embodiments are also described.

An implantable monitoring device includes first sensors to measure state information of one or both of a posture and an activity of a user and second sensors to measure bioinformation of two or more of an electrocardiogram (ECG) of a heart of the user, a pulmonary impedance of a lung of the user, a movement of the heart, a movement of a thorax including the lung, and a respiratory quotient (RQ) of the lung, two electrodes to detect bioinformation to measure one or both of the ECG and the pulmonary impedance, an analog circuit to process the detected bioinformation to measure the one or both of the ECG and the pulmonary impedance, and a processor to monitor an abnormal state of the heart and the lung of the user based on the state information and the bioinformation.

An implantable monitoring device includes first sensors to measure state information of one or both of a posture and an activity of a user and second sensors to measure bioinformation of two or more of an electrocardiogram (ECG) of a heart of the user, a pulmonary impedance of a lung of the user, a movement of the heart, a movement of a thorax including the lung, and a respiratory quotient (RQ) of the lung, two electrodes to detect bioinformation to measure one or both of the ECG and the pulmonary impedance, an analog circuit to process the detected bioinformation to measure the one or both of the ECG and the pulmonary impedance, and a processor to monitor an abnormal state of the heart and the lung of the user based on the state information and the bioinformation.

Systems and methods for identifying potential ablation sites using electrical parameter data are provided. A method includes geometrically isolating an arrhythmogenic substrate in a three-dimensional geometry. The method further includes generating a first cumulative map from a first dataset including electrical parameter data for each vertex in the isolated arrhythmogenic substrate, and generating a second cumulative map from a second dataset including additional data for each vertex. The method further includes generating a third cumulative map from the first and second cumulative maps, and displaying the third cumulative map on the three-dimensional geometry to facilitate identifying potential ablation sites.

Systems and methods for identifying potential ablation sites using electrical parameter data are provided. A method includes geometrically isolating an arrhythmogenic substrate in a three-dimensional geometry. The method further includes generating a first cumulative map from a first dataset including electrical parameter data for each vertex in the isolated arrhythmogenic substrate, and generating a second cumulative map from a second dataset including additional data for each vertex. The method further includes generating a third cumulative map from the first and second cumulative maps, and displaying the third cumulative map on the three-dimensional geometry to facilitate identifying potential ablation sites.