A biological information measurement device, including an electrode contact state detector including a first contact detection circuit connected to either the first electrode or the second electrode among the electrodes, a second contact detection circuit connected to the third electrode, and a contact state determinator for determining a contact state indicating which of the electrodes is in contact with a surface of the measurement target based on a first signal output from the first contact detection circuit and a second signal output from the second contact detection circuit, and an input receiver for receiving a contact of the electrode with respect to the surface of the measurement target as input of predetermined operation associated with the contact state.

Disclosed is an electronic device comprising a processor and at least one sensor circuit comprising at least a biometric sensor and a fatigue sensor. The processor may be configured so as to detect biometric data of an external object by means of the biometric sensor, detect fatigue data of the external object by means of the fatigue sensor if the biometric data exceeds a designated second range, and output, by means of a designated external device, a fatigue notification indicating a fatigued state if the fatigue data exceeds a designated third range. Other various embodiments identified in the description are possible.

A device for determining the physiological condition of a person in a simple manner, which device measures the pulse rate and based on that additionally determines the heart rate variability. In addition, at least one parameter should be used for the history of one of the two above-mentioned values. The deviation of the pulse rate and the heart rate variability from a normal variable is preferably integrated and used as an additional indicator. The device preferably includes a wearable electrocardiography device.

Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.

Methods of treating a valvular heart disease are provided. Methods for treating valvular heard disease include administering to a subject a therapeutically effective amount of at least one hedgehog pathway inhibitor. Also provided are methods for reducing fibrosis in a subject, which comprise administering to the subject a therapeutically effective amount of at least one hedgehog pathway inhibitor.

A core body temperature estimation device includes a core body temperature acquisition unit that acquires a core body temperature, at a first time, of an estimation target subject targeted for core body temperature estimation, a beat acquisition unit that acquires a beat, in a period including the first time, of the estimation target subject, and an estimation unit that estimates the core body temperature of the estimation target subject, based on the core body temperature at the first time acquired by the core body temperature acquisition unit and the beat in the period including the first time acquired by the beat acquisition unit, by using a core body temperature estimation model that estimates a core body temperature at a predetermined time, based on a core body temperature at an initial time and a beat from the initial time to the predetermined time.

This application discloses a premature beat detection method, an electronic device. The premature beat detection method in this application includes: performing premature beat detection on a user by using a premature beat detection function; determining a premature beat type of the user by using a premature beat type determining function when detecting that the user has a premature beat by using the premature beat detection function, and calculating premature beat load of the user based on detection data obtained by the premature beat detection function; and reminding the user of a premature beat risk when the calculated premature beat load is greater than a premature beat load threshold corresponding to the premature beat type determined by the premature beat type determining function.

This application discloses a premature beat detection method, an electronic device. The premature beat detection method in this application includes: performing premature beat detection on a user by using a premature beat detection function; determining a premature beat type of the user by using a premature beat type determining function when detecting that the user has a premature beat by using the premature beat detection function, and calculating premature beat load of the user based on detection data obtained by the premature beat detection function; and reminding the user of a premature beat risk when the calculated premature beat load is greater than a premature beat load threshold corresponding to the premature beat type determined by the premature beat type determining function.

In an aspect, the present disclosure provides a method comprising: (a) identifying a first negative and positive electromagnetic dipoles in a first electromagnetic field map associated with a heart of the individual at a first time; (b) identifying a second negative and positive electromagnetic dipoles in a second electromagnetic field map associated with the heart of the individual at a second time; (c) determining a first angle based on the first negative and positive electromagnetic dipoles; (d) determining a second angle based on the second negative and positive electromagnetic dipoles; and (e) determining a presence, an absence, or a likelihood of coronary artery disease in the individual, based at least in part on (i) whether the first angle differs from the second angle by at least 100 degrees, or (ii) whether there is a presence of a third electromagnetic dipole in the first or the second electromagnetic field map.

In an aspect, the present disclosure provides a method comprising: (a) identifying a first negative and positive electromagnetic dipoles in a first electromagnetic field map associated with a heart of the individual at a first time; (b) identifying a second negative and positive electromagnetic dipoles in a second electromagnetic field map associated with the heart of the individual at a second time; (c) determining a first angle based on the first negative and positive electromagnetic dipoles; (d) determining a second angle based on the second negative and positive electromagnetic dipoles; and (e) determining a presence, an absence, or a likelihood of coronary artery disease in the individual, based at least in part on (i) whether the first angle differs from the second angle by at least 100 degrees, or (ii) whether there is a presence of a third electromagnetic dipole in the first or the second electromagnetic field map.