A system and method is provided for monitoring a biological substance in a bodily orifice. The system includes a wearable device configured to be worn in a bodily orifice. A biosensor is carried by the wearable device and is constructed and arranged to obtain raw data regarding a biological substance in the orifice. The biosensor includes a processor circuit to provide processed data from the raw data, and a transmitter to wirelessly transmit the processed data to a second device.

The present invention relates to a method for determining the presence of a circulating tumor marker in the human body, comprising detecting the tumor marker in the vagina, wherein the tumor marker originates from a part of the body that is not the vagina. In a preferred embodiment, the tumor marker is detected by means of an aptamer. Even more preferably, the aptamer is present in a vaginal ring device. The vaginal ring device suitably comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The method can for example be used in the continuous monitoring of circulating tumor markers in oncologic patients or in the pretreatment and posttreatment follow-up of oncologic patients. The invention further relates to a vaginal diagnostic ring device for performing the method.

Bodily fluid indicator devices and methods are provided. Such devices and methods can effectively indicate whether the amount of bodily fluid being produced is within a measurable range. In an exemplary embodiment, a bodily fluid indicator device includes a substrate having a surface. Some portions of the surface are covered with a region of absorbent material and other portions of the surface are devoid of the absorbent material. A graduated scale or a reactive feature is printed on the absorbent material. The device is configured to indicate an amount and/or a composition a bodily fluid present on an area of a patient or subject.

The invention relates to a vaginal fluid monitoring device embedded into a feminine sanitary pad, said device comprising a stack of the following elements: An absorbent layer (100) configured to be in proximity to, and collect, a vaginal fluid; and A biosensing system (1000) in fluidic connection with said absorbent layer (100), said biosensing system (1000) comprising: A microfluidic chip (200) configured to perform an immunoassay to detect the presence and/or the concentration of at least one target biomarker comprised in a vaginal fluid; Means (300) for providing a readout of the presence and/or the concentration of said at least one target biomarker; and An electrode array (400) located along the microfluidic chip (200) configured to detect and analyze the flow of said vaginal fluid by impedance means; wherein said immunoassay is configured to detect the presence and/or the concentration of at least one target biomarker indicative of a pre-term birth (PTB) risk and/or premature rupture of membrane (PROM) risk. The invention also relates to a method for detecting at least one target biomarker comprised in a vaginal fluid.

A vaginal device configured to be inserted in a vagina of a user, the vaginal device comprising: a body comprising at least two electrodes configured to measure a fertility-related parameter of the user; a power source configured to provide power to the device; and an electrical system operably connected to the power source, the electrical system operably connected to one or more of the electrodes, the electrical system configured to switch one or more of the electrodes between charging and measuring functions.

Bodily fluid indicator devices and methods are provided. Such devices and methods can effectively indicate whether the amount of bodily fluid being produced is within a measurable range. In an exemplary embodiment, a bodily fluid indicator device includes a substrate having a surface. Some portions of the surface are covered with a region of absorbent material and other portions of the surface are devoid of the absorbent material. A graduated scale or a reactive feature is printed on the absorbent material. The device is configured to indicate an amount and/or a composition a bodily fluid present on an area of a patient or subject.

Method for measuring the presence of a compound or a physiological parameter in the human or animal body, comprising positioning an intravaginal ring that comprises a sensor for the compound or parameter to be measured in contact with the vaginal mucosa and recording a signal produced by the sensor. It is further disclosed a method for the combined administration and measurement of compounds in the human or animal body, comprising the administration of one or more biologically active compounds and the simultaneous and/or subsequent measurement of the presence and/or concentration of the same and/or another compound and/or physiological parameter that is the result of the administration of the one or more biologically active compounds, wherein the measurement is performed with a sensor that is in contact with the vaginal mucosa.

Bodily fluid indicator devices, systems, and methods are provided. Such devices, systems, and methods can effectively indicate whether the amount of bodily fluid being produced is within a measurable range, or can characterize various components or features of a bodily fluid. In an exemplary embodiment, a bodily fluid indicator device includes a substrate having a surface. Some portions of the surface are covered with a region of absorbent material and other portions of the surface are devoid of the absorbent material. A graduated scale or a reactive feature can be printed on the absorbent material. The device is configured to indicate an amount and/or a composition a bodily fluid present on an area of a patient or subject.

Bodily fluid indicator devices and methods are provided. Such devices and methods can effectively indicate whether the amount of bodily fluid being produced is within a measurable range. In an exemplary embodiment, a bodily fluid indicator device includes a substrate having a surface. Some portions of the surface are covered with a region of absorbent material and other portions of the surface are devoid of the absorbent material. A graduated scale or a reactive feature is printed on the absorbent material. The device is configured to indicate an amount and/or a composition a bodily fluid present on an area of a patient or subject.

A menstrual cycle monitoring system can be used to monitor fertility. The menstrual cycle monitoring system can comprise an intravaginal body which includes a hydration sensing probe(s) and/or sensor(s) and a temperature sensor oriented to measure bioelectrical impedance, resistance and/or conductance within cervical mucus and/or the vaginal environment and basal body temperature, respectively. A data communication unit stores and optionally transmits collected fertility data which includes at least the measured bioelectrical impedance, resistance and/or conductance and temperature over time. A power source can be electrically coupled to the hydration sensing probe(s) and/or sensor(s), temperature sensor and the data communication unit.